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Authors
Affiliations
1 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount
Opera, Nalgonda (Dist)-508284, Telangana, IN
2 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
3 Department of Pharmaceutics, Vijaya College of Pharmacy, Munaganur (V), Hayath Nagar (M), Hyderabad, Telangana, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 6, No 4 (2016), Pagination: 235-245
Abstract
Bosentan is an endothelial receptor antagonist (ERA) indicated for the treatment of Pulmonary arterial hypertension (PAH). The aim of the present study involves the development of controlled release tablets of bosentan. The tablets were prepared to release the drug for a prolong period of time within the GIT, to enhance the bioavailability, to minimize the dosing frequency, and to improve the patient compliance. The tablets were formulated by using various polymers like hydroxyl propyl methyl cellulose, acacia and xanthum. The formulated tablets were evaluated. The drug release from the optimized formulation (F7) was found to be the best after observing the results of dissolution rate and pre & post formulation studies.
Keywords
Controlled Release, Hydroxyl Propyl Methyl Cellulose (HPMC), Bioavailability, Endothelial Receptor Antagonist (ERA), Pulmonary Arterial Hypertension (PAH), Gastro-Intestinal Tract (GIT).
