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Ahmad, Sayeed
- Anti-oxidant Potential of Aqueous Extract of Cassia fistula L. Leaves
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Journal of Natural Remedies, Vol 10, No 2 (2010), Pagination: 181-183Abstract
The aqueous extract of Cassia fistula L. leaves showed an antioxidant activity as evaluated by studying the inhibition of lipid peroxidation, estimation of glutathione, scavenging effects on DPPH and H2O2, metal chelating ability and reducing power assay. Total phenol and flavonoid content of the extracts were also determined.Keywords
C. fistula L., Antioxidant Activity, Scavenging Activity- Application of Validated HPTLC Method for Dissolution Study of FDC Tablets Containing Telmisartan and Hydrochlorothiazide
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Authors
Affiliations
1 JK College of Pharmacy, Bilaspur, CG, 495001, IN
2 Department of Pharmaceutics, Hamdard University, New Delhi, 110062, IN
3 Department of Pharmacognosy and Phytochemistry, Hamdard University, New Delhi-110062, IN
1 JK College of Pharmacy, Bilaspur, CG, 495001, IN
2 Department of Pharmaceutics, Hamdard University, New Delhi, 110062, IN
3 Department of Pharmacognosy and Phytochemistry, Hamdard University, New Delhi-110062, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 4 (2017), Pagination: 1149-1154Abstract
A simple, selective, precise and HPTLC method for simultaneous determination of telmisartan and hydrochlorothiazide in the bulk drugs and in their fixed dose combination tablets (FDC) was developed and validated. The method was further applied in the dissolution study of formulated and marketed tablets containing these two drugs. The method employed HPTLC aluminium plates precoated with silica gel 60 F254 as the stationary phase. The solvent system consisted of toluene-ethyl acetate-methanol-glacial acetic acid, 6: 3: 1: 0.5 (v/v). The detection was performed at 272 nm. The RF values were 0.70 ± 2 for telmisartan and 0.44 ± 2 for hydrochlorothiazide. The linear relationships were obtained between peak area and amount of drugs in the range of 1-1000 ng spot-1 with correlation coefficient of 0.9992 for telmisartan and 0.9994 for hydrochlorothiazide. The method was validated for precision, robustness and recovery. The limits of detection and quantification were 15.54 and 48.44 ng spot-1 for telmisartan and 10.22 and 35.68 ng spot-1 for hydrochlorothiazide, respectively. Invitro drug release from prepared tablets showed better drug release when compared with marketed tablets.Keywords
Telmisartan, Hydrochlorothiazide, HPTLC, Dissolution Study.- Metal Analysis in Citrus sinensis Fruit Peel and Psidium guajava Leaf
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Authors
Affiliations
1 Department of Pharmaceutical Sciences, M. D. University, Rohtak, Haryana-124 001, IN
2 Division of Kidney Diseases & Hypertension, Feinstien Institute of Medical Research, Great Neck, New York – 11021, US
1 Department of Pharmaceutical Sciences, M. D. University, Rohtak, Haryana-124 001, IN
2 Division of Kidney Diseases & Hypertension, Feinstien Institute of Medical Research, Great Neck, New York – 11021, US