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Sravani, S.
- Development and Validation of UV-Spectrophotometric Method for Determination of Cephalexin
Abstract Views :563 |
PDF Views:2
Authors
G. Venkata Prasad
1,
S. Sravani
1,
B. Mohammed Ishaq
1,
M. Madhu
1,
Sreenivasulu Munna
1,
C. Gopinath
1
Affiliations
1 Department of Pharmaceutical Analysis, Annamacharya college of Pharmacy, Rajampet, Kadapa Dist, A.P, IN
1 Department of Pharmaceutical Analysis, Annamacharya college of Pharmacy, Rajampet, Kadapa Dist, A.P, IN
Source
Asian Journal of Research in Chemistry, Vol 6, No 5 (2013), Pagination: 490-494Abstract
To develop simple, sensitive, selective and accurate UV Spectrophotometric methods for the determination of Cephalexin in bulk drug and pharmaceutical formulations (Capsules). The absorbances were measured at 261(Method A) and 257 nm (Method B). The methods was found to be linear from a quantitation ranges of 5μg/ml to 40μg/ml (Method A) in Phosphate Buffer pH 2.0 and 5μg/ml to 50μg/ml (Method B) in 0.1 N HCl. The regression of the curves was Y = 0.020x - 0.021 (Method A) and Y = 0.014x - 0.102 (Method B). The methods gave satisfactory results in terms of repeatability and intermediate precision (RSD<1.010%) (Method A) and (RSD<0.589%) (Method B) 0.855 μg/mL and 2.85 μg/mL (Method A) and 2.357 μg/mL and 7.857 μg/mL were the LOD and LOQ values, respectively. The methods was validated and proved to be robust and rugged. The results of analysis for these methods have been validated statistically and by recovery studies.Keywords
Cephalexin, Spectroscopic Method, Phosphate Buffer (Ph 2.0), 0.1 N HclReferences
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- Antistress Activity of Aqueous Extract of Leaves of Centella asiatica. Linn by In Vivo Methods
Abstract Views :334 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmacology, Annai Veilankanni's Pharmacy College, Chennai-15, IN
1 Department of Pharmacology, Annai Veilankanni's Pharmacy College, Chennai-15, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 2, No 3 (2012), Pagination: 91-94Abstract
The antistress activity of aqueous extract of Centella asiatica. Linn leaves (Umbelliferae) were studied at doses of 100mg and 200mg/kg against tail suspension test. A dose dependent reduction in immobility time was observed in TST. Imipramine (30mg/kg, i.p) was selected as reference standard. The extract also significantly potentiate the Phenobarbitone induced sleeping time in mice. The findings from the present investigation indicates the extract has significant antistress as shown by its effects on different experimentally induced animal models.Keywords
Centella asiatica, Antistress, Tail Suspension Test, Phenobarbitone Induced Sleeping Time.References
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- Development and Validation of UV Spectrophotometric Method for Estimation of Lurasidone in Bulk and Pharmaceutical Formulations
Abstract Views :177 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Analysis, Malla Reddy College of Pharmacy, Secunderbad, Telangana, IN
1 Department of Pharmaceutical Analysis, Malla Reddy College of Pharmacy, Secunderbad, Telangana, IN