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Rao, S.
- Growth Pattern of Rural Indian Boys Aged 8-18 Years:A Longitudinal Study
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Authors
Affiliations
1 Department of Biometry and Nutrition Unit, Agharkar Research Institute, Agarkar Road, Pune 411 004, IN
1 Department of Biometry and Nutrition Unit, Agharkar Research Institute, Agarkar Road, Pune 411 004, IN
Source
The Indian Journal of Nutrition and Dietetics, Vol 35, No 6 (1998), Pagination: 149-156Abstract
People from most poor communities of developing countries like India have characteristically low body weight and substandard stature. As growth during adolescence contributes significantly to attainment of final anthropometric measurements of an individual, investigations on adolescent growth patterns among such communities assume significance.
- Survivin Expression in Canine Spontaneous Cutaneous and Subcutaneous Tumors and its Prognostic Importance
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Materials and Methods: Forty cases of canine cutaneous and subcutaneous tissue tumors on histopathological examination revealed various round cell, epithelial, and mesenchymal cell tumors. Survivin gene expression was detected in all tumors tested by TaqMan real-time polymerase chain reaction assay by comparative cycle threshold method.
Results: The mean survivin gene expression value of benign tumors was 0.94±0.63 folds and that of malignant tumors was 18.87±5.30 folds. Postsurgical follow up of 30 malignant tumor cases revealed death in 8, recurrence in 7, and neoplastic free alive status in 15 dogs with mean survivin fold difference values of 48.49±12.39, 14.63±6.37, and 5.034±2.27, respectively. The mean survivin gene expression value was significantly higher in malignant (30 cases, 18.87±5.30) compared to benign tumors (10 cases, 0.94±0.63), and it varied between various postsurgical follow-up groups (p<0.05). Survival analysis, using survivin gene expression median cutoff value of 3.74 in 30 malignant tumors, was performed to predict probable survival period in malignant cutaneous and subcutaneous tumors of dogs.
Conclusion: Results of the present study indicated that the expression of survivin in canine cutaneous and subcutaneous tumors has prognostic value, and survivin expression greater than median cutoff value of 3.74 has a poor prognosis.
Authors
N. Kavya
1,
S. Rao
1,
M. L. Sathyanarayana
1,
H. D. Narayanaswamy
1,
S. M. Byregowda
2,
L. Ranganath
3,
A. Kamaran
4,
K. M. Purushotham
2,
T. K. Kishore
1
Affiliations
1 Department of Veterinary Pathology, Veterinary College, Karnataka Veterinary Animal and Fisheries Sciences University, Bengaluru, Karnataka, IN
2 Department of Biotechnology, Institute of Animal Health and Veterinary Biologicals, Veterinary College, Karnataka Veterinary Animal and Fisheries Sciences University, Bengaluru, Karnataka, IN
3 Department of Veterinary Surgery and Radiology, Veterinary College, Karnataka Veterinary Animal and Fisheries Sciences University, Bengaluru, Karnataka, IN
4 Department of Veterinary Medicine, Veterinary College, Karnataka Veterinary Animal and Fisheries Sciences University, Bengaluru, Karnataka, IN
1 Department of Veterinary Pathology, Veterinary College, Karnataka Veterinary Animal and Fisheries Sciences University, Bengaluru, Karnataka, IN
2 Department of Biotechnology, Institute of Animal Health and Veterinary Biologicals, Veterinary College, Karnataka Veterinary Animal and Fisheries Sciences University, Bengaluru, Karnataka, IN
3 Department of Veterinary Surgery and Radiology, Veterinary College, Karnataka Veterinary Animal and Fisheries Sciences University, Bengaluru, Karnataka, IN
4 Department of Veterinary Medicine, Veterinary College, Karnataka Veterinary Animal and Fisheries Sciences University, Bengaluru, Karnataka, IN
Source
Veterinary World, Vol 10, No 10 (2017), Pagination: 1286-1291Abstract
Aim: The present study was carried out to know the expression level of survivin, an inhibitor of apoptosis protein with an objective to determine its prognostic importance in cutaneous and subcutaneous tissue tumors of dogs.Materials and Methods: Forty cases of canine cutaneous and subcutaneous tissue tumors on histopathological examination revealed various round cell, epithelial, and mesenchymal cell tumors. Survivin gene expression was detected in all tumors tested by TaqMan real-time polymerase chain reaction assay by comparative cycle threshold method.
Results: The mean survivin gene expression value of benign tumors was 0.94±0.63 folds and that of malignant tumors was 18.87±5.30 folds. Postsurgical follow up of 30 malignant tumor cases revealed death in 8, recurrence in 7, and neoplastic free alive status in 15 dogs with mean survivin fold difference values of 48.49±12.39, 14.63±6.37, and 5.034±2.27, respectively. The mean survivin gene expression value was significantly higher in malignant (30 cases, 18.87±5.30) compared to benign tumors (10 cases, 0.94±0.63), and it varied between various postsurgical follow-up groups (p<0.05). Survival analysis, using survivin gene expression median cutoff value of 3.74 in 30 malignant tumors, was performed to predict probable survival period in malignant cutaneous and subcutaneous tumors of dogs.
Conclusion: Results of the present study indicated that the expression of survivin in canine cutaneous and subcutaneous tumors has prognostic value, and survivin expression greater than median cutoff value of 3.74 has a poor prognosis.
Keywords
Cutaneous and Subcutaneous Tumors, Prognostic Value, Quantitative Real-Time Polymerase Chain Reaction, Survivin.Full Text