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Asian Journal of Pharmaceutical Research and Health Care, Vol 3, No 1 (2011), Pagination: 15-21
Abstract
A gel forming Polysaccharide gum obtained form the bark of Araucaria bidwilli was employed as a matrix sustained release tablet formulation of Diclofenac sodium (a non steroidal anti inflammatory agent). The effect of Araucaria bidwilli gum ( Natural ) and Synthetic polymer Hydroxypropyl methyl cellulose ( HPM C K4 M ) on the release of Diclofenac sodium was studied. The FT - IR spectroscopic studies of drug, gum and mixture indicated no chemical interaction . Six formulations were prepared by wet granulation method containing Araucaria bidwilli gum pow der concentration 10 % 20 % & 30 % w \ w and 10 % 20% &30% w \ w of HPMC K4M with sufficient volume of granulating agent Polyvinyl pyrrolene (PVP K 30) , Avicel pH101 as diluents , Magnesium stearate and Aero silis used lubricant and glidant respectively . This study was carried out to find out the difference between synthetic and natural gum and whether synthetic gum can be replaced by natural gums. Physical and techno logical studies of granules and tablets were compliance with Pharmacopoial standards . The drug release increased with Araucaria bidwilli gum when compared to synthetics polymer concentration. The value of release exponent were found to be almost straight line and regression coefficient value between 0. 9 38 and 0. 99 8 . This implies that the release mechanism is diffusion. Formulation F3 (contained 30% w \ w Araucaria bidwilli gum) met the desired requirements for a sustained release dosage form.
Keywords
Diclofenac sodium, Araucaria bidwilli, HPMC K4 M, Wet Granulation, Sustained Release.
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