Informatics Publishing Limited

K. L. Bairy , K. Roopa , S. Malini , C. M. Rao

Abstract

Objectives: To study the possible antiulcer effects of alcoholic extract of Tinospora cordifolia in different animal models of ulcers. Methods and materials : The alcoholic extract of the whole plant was prepared and tested for antiulcer activity at the dose of 400 mg/Kg PO in pyloric ligation, ibuprofen and cold restraint induced gastric ulcer models. The effect of the extract was compared with famotidine (3.6mg Kg PO). Besides, the effect was also compared with misoprostal (7.2 μg/kg PO) in case of ibuprofen induced ulcer model. The antiulcer effects of the drugs were assessed on the parameters such as number, size and index of ulcers and the volume, acidity, and pH of gastric juice. Result: The extract of Tinospora cordifolia, famotidine and misoprostol significantly (p<0.05) reduced ulcer index in the models employed. While the antiulcer effect of the extract was comparable to that of the standard drugs in ibuprofen and stress induced ulcer models, its effect was significantly (p<0.05) lesser than that of famotidine in pyloric ligation method. Conclusion: Tinospora cordifolia possesses gastric ulcer protective principles.

Keywords

Tinospora cordifolia, Gastric Ulcer, Famotidine, Antiulcer

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S. Malini ¹, E. Kannan ², A. Valarmathi ³

Affiliations
1 Department of Computer Applications, PABCET, Tiruchirappalli, IN
2 Veltech Dr.R.R & Dr.S.R Technical University, Chennai, IN
3 Department of Computer Applications, Anna University of Technology, Tiruchirappalli, IN

Abstract

A Mobile Ad-hoc Network (MANET) is a dynamic wireless network that can be formed without the need for any pre-existing infrastructure in which each node can act as a router. The suitability of multi-path AOMDV routing protocol in such a network was accessed in mobility biased MANET and compared with the performance of its single-path counterpart AODV. A predefined network topology was created and NS-2 simulation was performed at different mobility based scenarios. The performance of AODV and AOMDV was evaluated using responses such as throughput, packet loss and end-to-end delay. The results indicated that AODV exhibited higher throughput and lower end-to-end delay. In the case of AOMDV, the more frequent route discovery might have hampered the available bandwidth and exhibited poor performance. The only positive aspect of AOMDV was its performance with lower packet loss. The routing overhead associated with multi-path routing is found to be the major concern in multipath based routing protocols.

Keywords

MANET, AODV, AOMDV, Performance Metrics.

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