A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Beura, S.
- Nano Selenium: Potential Boon and Novel Approaches for Cancer Chemoprevention
Authors
1 School of Pharmacy, Chouksey Engineering College, Bilaspur- 495004, IN
2 Dept. of Pharmacy, Bharat Technology, Banitabla, Uluberia-711316, W.B., IN
3 Nababharat Shiksha Parishad, Orissa, Rourkela-769014, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 1 (2011), Pagination: 15-16Abstract
Chemoprevention agents can also identified by systematic evaluation of agents that acts at specific molecular targets with respect to cancer by using laboratory assay. The use of specific nutrients, other chemical compounds in the prevention of cancer is referred to as chemoprevention. Now a days, very less research work focusing on the effect of substrate bound elemental Se nanoclusters on cancer growth. The mechanisms by which nano selenium compounds inhibit tumor formation during the initiation phase of carcinogenesis have been explored in vitro. Selenium nanoparticles are very beneficial for treatment of cancer.Keywords
Nanoselenium, Cancer Chemoprevention.
References
- Higginson J. Changing concepts in cancer prevention: limitation and implication for future research in environmental carcinogenesis. Cancer Res. 1988: 48: 1381.
- Arteel G.E, Sies H. The biochemistry of selenium and the glutathione system. Environmental Pharmacology and Toxicology. 2001: 10: 153 - 158.
- EI-Bayoumy K. The protective role of selenium on genetic damage and on cancer. Mutat Res. 2001: 475: 123 - 129.
- Singer B and Grunberger D. Molecular Biology of Mutagens and Carcinogens. Plenum. New York. 1983.
- Meyskens F.L. Thinking about causality and chemoprevention. J.Nat.Cancer. !988: 24: 1278.
- Lippman S.M, Benner S.E and Hong W.K. Cancer chemoprevention. J.Clin.Oncol. 1994: 12: 851 - 873.
- Ito N and Imaida K. Strategy of research for cancer chemoprevention. Teratog.Carcinog.Mutag. 1992: 12: 79.
- Waisburger J.H. Nutritional approach to cancer prevention with emphasis on vitamins, antioxidants and carotenoids. Am.J.Clin.Nutr. 1991: 53: 226.
- Bagnall K.W. The Chemistry of Selenium, Tellurium and Polonium. Elsevier Publishing Company. Amsterdam Netherlands. 1996.
- Zhang J, Wang X and Xu T. Elemental selenium at nanosize (Nano - Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: Comparison with Se - methyl selenocysteine in mice. Toxicol Sci. 2008: 101: 22 - 31.
- Zang J.S, Gao X.Y, Zhang L.D and Bao Y.P. Biological effects of a nano red elemental selenium. Biofactors. 2001: 15: 27 - 28.
- Zhang J, Wang H, Bao Y and Zhang L. Nano red elemental selenium has no side effect in the induction of selenoenzymes in both cultured cells and mice. Life Sci. 2004: 75: 237 - 244.
- Ip C, EI-Bayoumy K, Upadhyaya P, Ganther H, Vadhanavikit S, Thompson H. Comparative effect of inorganic and organic selenocyanate derivatives in mammary cancer chemoprevention. Carcinogenesis. 1994: 15: 187 - 192.
- Combs G.F. Impact of selenium and cancer prevention findings on the nutrition health paradigm. Nutr. Cancer. 2001: 40 (1): 6 - 11.
- Overview on Liposome as Drugs Carrier
Authors
1 Balaka, Risi Bankim Sarani, Near Padakhep Club, West Hridaypur, P.O: Hridaypur, Kolkata- 700127, W.B, IN
2 Dept. of Pharmacy, Bharat Technology, Banitabla, Uluberia-711316, W.B., IN
3 Dept. of Pharmacy, Kanak Manjari Institute of Pharmaceutical Sciences, Rourkela-769015, Orissa, IN
4 Nababharat Shiksha Parishad, Orissa, Rourkela-769014, Orissa, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 6 (2010), Pagination: 374-377Abstract
The main objective of drug delivery systems is to deliver a drug effectively, specifically to the site of action and to achieve greater efficacy and minimise the toxic effects compared to conventional drugs. Amongst various carrier systems, liposomes have generated a great interest because of their versatility and have played a significant role in formulation of potent drugs to improve therapeutics. Enhanced safety and efficacy have been achieved for a wide range of drug classes, including antitumor agents, antivirals, antimicrobials, vaccines, gene therapeutics etc. Liposomes were first described by British hematologist Dr Alec D Bangham. These are vesicular concentric structures, range in size from a nanometer to several micrometers, containing a phospholipid bilayer and are biocompatible, biodegradable and nonimmunogenic.
There are three types of liposomes - MLV (multilamillar vesicles), SUV (Small Unilamellar Vesicles) and LUV (Large Unilamellar Vesicles). Phospholipids are amphipathic, i.e., part of their structure is hydrophilic and the other is hydrophobic. Liposome can carry both hydrophobic and hydrophilic molecules. They can be filled with drugs and used to deliver drugs. Another interesting property of liposomes is their natural ability to target cancer by their rapid entry into tumor sites. Anti-cancer drugs such as Doxorubicin (Doxil), Camptothecin etc. are currently being marketed in liposome delivery systems. Liposomes that contain low or high pH can be constructed such that dissolved aqueous drugs will be charged in solution. Another strategy for liposome drug delivery is to target endocytosis events and can also be decorated with opsonins and ligands. The use of liposomes for transformation of DNA into a host cell is known as lipofection. In addition to these applications, liposomes can deliver the dyes to textiles, pesticides to plants, enzymes and nutritional supplements to foods, and cosmetics to the skin. The use of liposomes in nano cosmetology also has many benefits, including improved penetration and diffusion of active ingredients, selective transport of ingredients, greater stability of active, reduction of unwanted side effects, and high biocompatibility. Despite of their potential value, the major obstacles are the physical stability and manufacture of the liposomal products and these problems still remain to be overcome. More liposome based drug formulations can be expected in the near future both for delivery of conventional drugs and for new biotechnology therapeutics such as recombinant proteins, antisense oligonucleotides and cloned genes.
Keywords
Multilamillar Vesicles, Unilamellar Vesicles, Phospholipids.- Effect of Physical Regulation on Plant Growth and Flower Production of in vitro Raised Hybrid Gerbera
Authors
1 Department of Floriculture and Landscapting, College of Agriculture, Orissa University of Agriculture and Technology, Bhubaneswar (Odisha), IN
Source
The Asian Journal of Horticulture, Vol 10, No 2 (2015), Pagination: 237-241Abstract
Experiment was carried out to find out the impact of physical treatment on growth and flowering of in vitro raised hybrid gerbera plants in Department of Floriculture and Landscaping. The findings of physical treatments followed by antibiotics revealed that disbudding followed by neospirine application enhanced the plant spread, number of leaves per plant, stalk length, number of flowers per plant and flower diameter throughout the investigation period from January to June 2011. The treatment recorded most spectacular effect during the month of March with maximum plant spread (33.57 cm), number of leaves per plant (12.7), longer stalk (35.77 cm), number of flowers per plant (2.63) and larger flower (8.23 cm dia.). Pressing by heated steel rod at the axil of the leaf was found to be inferior among all the physical treatments.