Informatics Publishing Limited

Ashish Jain ¹, Apoorvi Sharma ¹, Mukesh Bhaisare ², S. Banerjee Pooja ¹, Megha Sharma ¹

Affiliations
1 Shri Ram Institute of Technology, Pharmacy, Near ITI Madhotal, Jabalpur- 482002, (M.P.), IN
2 B.M.College of Pharmaceutical Education and Research, Vlll. Gokanya, Umarikeda, Khandwa Road, Indore- 452001, (M.P.), IN

Abstract

A simple and rapid spectrophotometric dual wavelength method has been developed for simultaneous estimation of amlodipine besylate and valsartan in tablet dosage form. Two wavelengths selected were 227 and 244nm, for estimation of valsartan and 360 nm for amlodipine besylate using methanol as a solvent. Both the drugs obeyed Beer-Lambert's law over the concentration range 5-100μg/ml and 5-50μg/ ml for valsartan and amlodipine besylate. The r² for valsartan and amlodipine besylate were 0.9982 and 0.9973 with mean percent recovery of 100.23 and 99.66 respectively. The Relative standard deviations for validation parameters were found to be less then the 5%.

Keywords

Amlodipine Besylate, Valsartan, Tablet, Spectrophotometric Method.

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