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Vilas A. Sawant ¹, P. Jayprabha ², V. S. Shende ³, S. N. Borkar ³, V. S. Wakale ³, S. R. Deore ³, G. Y. Dame ³, A. O. Barve ⁴, V. K. Chatap ³

Affiliations
1 Dept. of Pharmaceutics, Sharadchandra Pawar College of Pharmacy, Otur, Pune-409412, (MS), IN
2 Erode College of Pharmacy, Erode, Tamilnadu, IN
3 Sharadchandra Pawar College of Pharmacy, Otur, Pune-409412, IN
4 Oriental College of Pharmacy and Research, Indore (M.P), IN

Abstract

The objective of the present study was to develop once daily sustained release matrix tablet of Mosapride or its pharmaceutically acceptable salts with pharmaceutically acceptable excipients. The matrix tablets were prepared by dry granulation (slugging/roller compaction) technique by using hydrophilic matrix polymer such as hydroxyl propyl methyl cellulose (HPMC) of two different viscosity grades. The granules were evaluated for bulk density, tapped density, angle of repose, compressibility index etc. The prepared matrix tablets were taken for release study. The results of invitro dissolution study shown that the formulation F6 (HPMC K4M: HPMC K15M) 1:1.235, exhibited satisfactory drug release pattern and total drug release pattern was very close to theoretical release profile. The mechanism of the drug release from sustained release matrix tablet of formulation F6 was fickanian diffusion.

Keywords

Sustained Release Matrix Tablet, HPMC, Mosapride.

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D. J. Sawarkar ¹, C. Vijaya ², A. O. Turaskar ², V. S. Shende ³, V. K. Chatap ³, V. A. Sawant ³, S. N. Borkar ³

Affiliations
1 Dept. of Pharmaceutics, Sharadchandra Pawar College of Pharmacy, Otur, Pune-409412, (MS), IN
2 Ultra College of Pharmacy, Madurai, (TN), IN
3 Sharadchandra Pawar College of Pharmacy, Pune, Otur, (MS), IN

Abstract

The objective of the present study was to investigate the hepatoprotective activity of alcoholic and ethyl acetate leaves extract of Ziziphus mauriatiana against paracetamol induced hepatotoxicity. The material was dried in shade, they were powdred and extracted with alcohol and ethyl acetate. Preliminary phytochemical tests were done in the presence of phytoconstituents like flavonoids, saponins, phenolic compounds and tannins. The present activity on rats shown alteration in the level of biochemical markers of hepatic damage like ALT, AST, ALP, Bilirubin and Protin were tested in both paracetamol treated and untreated groups. Wistar rats were induced hepatotoxicity by oral administration of paracetamol (640mg/kg) for 10 days. The hepatotoxicity induced rats were used for the studies. Ethyl acetate extract (400mg/kg), ethanol extract (300mg/kg) and standard (Silymarin) reduced the elevated levels of enzyme markers such as AST, ALT, ALP, and total bilirubin and increased in total proteins levels. The histopathological investigations also supported above effect of ethyl acetate and ethanolic extract by indicating the reduction in inflammatory collection and absence of fatty vacuoles in liver sections.

Keywords

Ziziphus mauriatiana, Hepatoprotective, Paracetamol, Liver.

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