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Vadvalkar, S. M.
- Novel Approach in Transdermal Drug Delivery System: Transferosome
Abstract Views :499 |
PDF Views:1
Authors
Affiliations
1 Nanded Pharmacy College, Opp-Kasturba Matru Seva Kendra, Shyam Nagar, Nanded -431605 Maharashtra, IN
1 Nanded Pharmacy College, Opp-Kasturba Matru Seva Kendra, Shyam Nagar, Nanded -431605 Maharashtra, IN
Source
Research Journal of Pharmacy and Technology, Vol 6, No 1 (2013), Pagination: 17-21Abstract
Transdermal drug delivery system is emerging system as compared to oral and parenteral. In TDDS, patch system was developed to control the release of drug. Conventional transdermal drug delivery system achieved advantages over the oral and parenteral. Consequently a number of vesicular drug delivery systems such as liposomes, niosomes were been developed as novel transdermal drug delivery system. Firstly, it delivers the drug at a rate directed by the needs of the body, over the period of treatment. Secondly, it channels the active entity to the site of action. Liposomal as well as niosomal systems, are not suitable for transdermal delivery, because of their poor skin permeability, breaking of vesicles, leakage of drug, aggregation, and fusion of vesicles. To overcome these problems, a new type of carrier system called "transfersome", has recently been introduced, which is capable of transdermal delivery of low as well as high molecular weight drugs.Transferosome is a supramolecular entity that can pass through a permeability barrier and there by transport material from the application to the destination site. These are more elastic than standard liposomes. Transferosome has been widely used as a novel carrier for effective transdermal drug delivery. Transferosome enhances the penetration of most of the low as well as high molecular weight drugs, while in case of lipophilic drugs the entrapment efficiency can reach upto 90%. it is now widely used as a novel carrier for both systemic as well as topical delivery of drugs.Keywords
TDDS, CTDDS, NTDDS, Transfersome,LiposomeReferences
- Vesicular Approach for Drug Delivery into or Across the Skin: Current Status and Future Prospects. http://priory.com/pharmol/ Manuscript-Jain.htm
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- Nanda A, Nanda S, Dhall M, Rao R. Transferosome: A Novel Ultradeformable Vesicular Carrier for Transdermal Drug Delivery, Drug Deliv.5(9) ; 2005: 395.
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- Two Wavelength Method for Estimation of Risperidone and Trihexyphenidyl HCl in Combined Tablet Dosage Form
Abstract Views :349 |
PDF Views:2
Authors
Affiliations
1 Nanded Pharmacy College, Opp- Kasturba Matru Seva kendra, Shyam Nagar, Nanded -431605, Maharashtra, IN
1 Nanded Pharmacy College, Opp- Kasturba Matru Seva kendra, Shyam Nagar, Nanded -431605, Maharashtra, IN
Source
Asian Journal of Research in Chemistry, Vol 6, No 1 (2013), Pagination: 07-10Abstract
No one UV Spectrophotometric method is available for simultaneous estimation of Risperidone (RIS) and Trihexyphenidyl HCL (THP). The objective of present work is to develop a new, simple, accurate and sensitive UVspectrophotometric two wavelength method for simultaneous determination of RIS and THP in combined pharmaceutical dosage form. Two wavelength i,e 238 nm and 271 nm were selected for estimation of RIS where as wavelength 217 nm was selected for estimation of THP using 0.1 N HCL solution as solvent . RIS and THP shows linearity in the concentration range of 0-40 μg/ml and 0-80 μg/ml respectively. The method was validated statistically.Keywords
Risperidone, Trihexyphenidyl HCL, Two wavelength methodReferences
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- Sherif EL, Zeanu B, Houssini M. High performance liquid chromatographic and thin layer densitometric methods for the determination of risperidone in the presence of its degradation products in bulk powder and in tablets. J Pharm Biomed Anal. 36; 2005:975-81.
- Tomar RS, Joseph TJ, Murthy AS, Yadav DV, Subbaiah G, Krishna Reddy KV. Identification and characterization of major degradation products of risperidone in bulk drug and pharmaceutical dosage forms. J Pharm Biomed Anal. 36; 2004:231-35.
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- Bladania SL, Bhatt KK, Mehta RS, Shah DA. RP-HPLC estimation of risperidone in tablet dosage forms. Indian J Pharm Sci. 70; 2008:494-7.
- Mahadik KR., Aggarwal H., Kaul N. RP-HPLC Estimation of Trihexyphenidyl HCl and Chlorpromazine HCl in Tablets. Indian Drugs. 39(8); 2002: 441-445.
- Forced Degradation Study:An Important Tool in Drug Development
Abstract Views :178 |
PDF Views:1
Authors
Affiliations
1 CRPS, Nanded Pharmacy College, Nanded, IN
2 Nanded Pharmacy College, Nanded, IN
1 CRPS, Nanded Pharmacy College, Nanded, IN
2 Nanded Pharmacy College, Nanded, IN