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- A. P. Maske
- G. N. Sapkale
- A. B. Kure
- P. B. Kumbhar
- Pruthviraj S. Pawar
- Prajakta P. Karpe
- Prabhakar Jadhav
- Atul Alkunte
- Santosh J. Pawar
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- Shirish Satish Dongare
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- G. S. Mate
- Ganesh S. Mate
- S. S. Dongare
- N. S. Naikwadi
- M. B. Patil
- G. Hunasnalkar Shivraj
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Journals
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Patil, S. M.
- Unique Approaches to Vaccine Development Formulation and Delivery
Abstract Views :224 |
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Authors
Affiliations
1 ASPM's. K. T. Patil Collage of Pharmacy Osmanabad- 413 501 MS, IN
2 ASPM's. K. T.Patil Collage of Pharmacy Osmanabad- 413 501 MS, IN
1 ASPM's. K. T. Patil Collage of Pharmacy Osmanabad- 413 501 MS, IN
2 ASPM's. K. T.Patil Collage of Pharmacy Osmanabad- 413 501 MS, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 2 (2010), Pagination: 99-102Abstract
A Vaccine is a preparation, which is used to stimulate immune system, improves immunity to a particular disease. Vaccine can be prophylactic or therapeutic. Most vaccine registered for use is designed to prevent or control acute human infections. The conventional approaches to vaccine Research and Development are as Isolation and Characterization of disease causing organism, to discover methods to effectively immunize and protect susceptible host and to develop assay to measure immune response and identity immune correlates of protection, Manufacturing and Preclinical development, Clinical and Field testing in humans. New approaches to vaccine development are as use of anti-idiotype antibody preparation to mimic B-cells epitops, Synthesis of oligo or polypeptides that reflect naturally occurring a sequence of protein of pathogen. rDNA Transfection of cells with inserted DNA/CDNA into genome of other viruses and bacteria. New prophylactic and therapeutic vaccines will prevent and potentially cure disease. New delivery systems for human vaccines are being developed to enhance cellular and Mucosal immunity, as well as ease of use, advances in current vaccines such as conjugated pneumococcal vaccines for adults, nasal spray vaccines for Influenza and adult a cellular pertussis vaccine will provide an efficient way to of longlasting protective immunity. There is as of today no TH1 adjuvant efficient in humans. Such adjutants are needed to develop powerful therapeutic vaccines against cancer or chronic infectious diseases. New vaccine delivery technology will provide easier delivery routs such as transcutaneous, depot, nasal, and oral delivery without compromising efficacy.Keywords
Vaccines, Development, Delivery, Approaches.
References
- USP-NF Asian edition 2007 volume-3. P.N.2548, 2275,2356,2964,3485.
- British pharmacopoeia 2007 volume-3r,3048-3150.
- Recent advances in drug discovery (pharmaceutical biotech) medicinal chemistry 55.Jansen, K.U. et al. Vaccine 13, 1509-1514 (1995). | Article | PubMed | ChemPort |
- Knicksen PJ. and Miller, W.J. in Vaccines: New Approaches to Immunological Problems 1992,177−204.
- Brown D.R.,Vaccine 2002,22, 2936-2942.
- Fife, K.H. et al. Vaccin e2002, 22, 2943-2952.
- Koutsky, L.A. et al. N. Engl. J. Med. 2002,347, 1645-1651.
- Clark, H.F. et al. Pediatr. Infect. Dis. J. 2003,22, 14-20 .
- Clark, H.F. et al. J. Pediatr. 2004,144, 184-190.|
- Pisano, G.P. in The Development Factory 1997 (Harvard Business School Press, Boston,).
- Quality Assurance in Clinical Trial
Abstract Views :165 |
PDF Views:0
Authors
Affiliations
1 ASPM's. K. T. Patil College of Pharmacy Osmanabad-413 501(MS), IN
1 ASPM's. K. T. Patil College of Pharmacy Osmanabad-413 501(MS), IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 1 (2010), Pagination: 1-4Abstract
Clinical research is a systemic study of the drug biologic or device on human subject.Any investigation in human s meant to determine the clinical, pharmacological pharmacokinetic, pharmacodynamic, and or risk/benefits properties of a drug device or biologic. There are four phases in clinical trials. Need of quality assurance in clinical trial is for building quality in upfront assuring quality through the process. As in clinical trial we are dealing with a human life and every thing is for patient safety. When drug development reaches the stage where the drug product are produced for clinical trials in human, then compliance with the cGMP regulation is required. The drug product must be produced in a qualified facility, using laboratory and other equipments that have been validated. Operating under a State of Control produces drug products for which there is adequate level of assurance Quality, Strength, Identity and Purity The manufacturer is responsible for the quality of the Pharmaceutical product at batch release by applying GMP During manufacturing, packaging, QC testing. The product should be stable throughout the shelf-life Quality assurance for the product should be Monitoring environmental conditions under which products are manufactured/stored, air and water systems to prevent contamination, Monitoring of personnel QA at Clinical Site to Supervise, Maintain Records, Adhere to Protocol, Learn investigator procedures, Report Adverse effect, Retain Records and Train Staff.
Keywords
Clinical Research, Quality Assurance, Pharmacodynamic, cGMP.References
- Elisabeth P. compliance corporate Sanafi research, gentilly codex, France, 1992, 2, 189-196.
- Chillarege. Software testing best practices, IBM research technical report, 1999, 26.
- Chase D, and Letzel H. System audit of contract research organizations in Germany lat.J.pharma med. 2001, 15, 191-196.
- Gierend M, Clinical trail, 2009, 6, 373-377.
- Washington DC. U.S. Depatment of health and human services, code of federal regulation, 2002, 42, 493.
- I.J. Townshend and. Bissel AF.Sampling for Clinical Report Auditing," Statistician 1987, 36, 531-539.
- ICH/GCP Consolidated Guidelines, E6.
- Lisa Henderson; Applied Clinical Trials, 2009,1.
- MRC Guidelines for Good Clinical Practice in Clinical Trials, 20 Park Crescent, London, W1N 4AL, United Kingdom, 1998.
- Pre-Formulation and Evaluation of Herbo-Mineral Ointment and Cream
Abstract Views :170 |
PDF Views:0
Authors
Affiliations
1 ASPM’s K. T. Patil Collage of Pharmacy, Osmanabad -413 501(MS), IN
2 Govt. College of Pharmacy, Karad (MS), IN
1 ASPM’s K. T. Patil Collage of Pharmacy, Osmanabad -413 501(MS), IN
2 Govt. College of Pharmacy, Karad (MS), IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 1, No 1 (2010), Pagination: 30-32Abstract
The herbo-mineral formulations are developed by the combination of Shat-dhaut-ghrit and ointment or cream base. In this combinations, medicaments such as shendur, camphor, muddar-sing and pale catechu are incorporated . The herbo-mineral ointment is prepared by fusion method.1,2 Bees wax, White soft paraffin, Wool fat, Cetostearyl alcohol these are used as oily base. These formulations are used for treatment of bacterial, viral, funal infection.3,4 The result obtained after evaluation were complies with I.P standard.The formulations of herbo-mineral have high tendency to treat the various skin diseases such as wound, ulcer, Erythema multiformae, acne vulgaris and chronic infection of skin.Keywords
Herbo-Mineral Formulations, Anti Bacterial, Anti Viral, Anti Fungal.- Nanocapsules as a Novel Drug Delivery System
Abstract Views :205 |
PDF Views:0
Authors
Affiliations
1 C/o-D. K. Mane’s house, Near Mukteshwar-Ashram, Vasant Nagar, Nanded 431602(MS), IN
2 Department of Pharmaceutics, ASPM’s K.T. Patil College of Pharmacy, Osmanabad 413501, IN
1 C/o-D. K. Mane’s house, Near Mukteshwar-Ashram, Vasant Nagar, Nanded 431602(MS), IN
2 Department of Pharmaceutics, ASPM’s K.T. Patil College of Pharmacy, Osmanabad 413501, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 2 (2010), Pagination: 146-155Abstract
Nanocapsules have been proposed as drug carrier that may be used as to realize magic bullet in 20th century, which refers to capable of targating a perticular and releasing its content when desired at site of action Nanocapsules prepared from preformed polymers as active substances carriers is presented. This entails a general review of the different preparation methods nanoprecipitation, emulsion-diffusion, double emulsification, emulsion-coacervation, polymer-coating and layer-by-layer, from the point of view of the methodological and mechanistic aspects involved. Encapsulation of the active substance and the raw materials used. Similarly, a comparative analysis is given of the size, zeta-potential, encapsulation efficiency, active substance Release, stability and in vivo and in vitro pharmacological performances, using as basis the data reported in the different research works published.Keywords
Nanocapsules, Encapsulation Efficiency, Zeta-Potential, Encapsulation Method.- Characterization and Evaluation of Glibenclamide Transmucosal Drug Delivery System
Abstract Views :172 |
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Authors
Affiliations
1 K.L.E’s College of Pharmacy, Nipani –591237, Dist: Belgaum, Karnataka, IN
2 K.L.E’s College of Pharmacy, Nipani, Karnataka, IN
1 K.L.E’s College of Pharmacy, Nipani –591237, Dist: Belgaum, Karnataka, IN
2 K.L.E’s College of Pharmacy, Nipani, Karnataka, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 1 (2010), Pagination: 44-46Abstract
In an attempt to develop mucoadhesive buccal drug delivery system, buccal tablets of Glibenclamide were prepared using polymers such as carbopol-934, Hydroxypropylmethyl cellulose HPMCK4M, and sodium carboxy methyl cellulose (Sod. CMC) in various proportions and combinations. The tablets were evaluated for different physicochemical parameters like weight variation, friability, hardness, drug content, water absorption studies, bioadhesive performance, release characteristics and surface pH. Tablets containing carbopol-934 and sodium CMC showed a maximum in vitro release of 82.27%. The formulations were subjected to graphical treatments according to Higuchi's equation and Peppa's equation. The best formulation F1 confirmed that the release mechanism is by diffusion, the rate of release following first order kinetic model.
Keywords
Buccal Tablet, Bioadhesive Performance, Release Characteristics, Surface pH.- Antidiabetic Activity of Marsilea quadrifolia linn in Alloxan-Diabetic Rats
Abstract Views :157 |
PDF Views:0
Authors
Affiliations
1 Aspm’s K. T. Patil College o Pharmacy, Post Box No.-56, Siddharth Colony, Siddharth Nagar, Osmanabad 413501(M.S.), IN
2 ASPM’s K. T. Patil. College of Pharmacy, Osmanabad, IN
1 Aspm’s K. T. Patil College o Pharmacy, Post Box No.-56, Siddharth Colony, Siddharth Nagar, Osmanabad 413501(M.S.), IN
2 ASPM’s K. T. Patil. College of Pharmacy, Osmanabad, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 1 (2009), Pagination: 15-17Abstract
The different extracts of the Marsilea quadrifolia linn (Family- Marsileaceae) were tested for anti-diabetic activity, by normal rats and alloxan induced diabetic rats. Aqueous and methanol extracts had shown significant protection and lowered the blood glucose level. In alloxan induced diabetic rats the maximum reduction in blood glucose was observed after 72h at a dose level of 200mg/kg body weight. In short term treatment of alloxan induced diabetic rats was determined by measuring blood glucose levels on 0,24,48 and 72h. Both the extracts showed a significant anti- diabetic activity comparable with that of glibenclamide. These results indicate that the Marsilea quadrifolia linn plant possess significant anti-diabetic activity.Keywords
Antidiabetic Activity, Marsilea quadrifolia, Glucose, Glibenclamide.- Anti-Inflammatory Activity of Orthosiphon Stamnineus Benth Bark Extract
Abstract Views :170 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacology, Aspm’s K.T.Patil. College of Pharmacy, Osmanabad, Post Box No.-56, Siddharth Nagar, Osmanabad, 413501(M.S.), IN
2 A.S.P.M’s K.T. Patil College of Pharmacy, Siddharth Nagar, Barshi Road, Osmanabad, (M.S.) 413501, IN
3 Appasaheb Birnale College of Pharmacy, Shivaji Nagar, Sangali (M.S.), IN
1 Department of Pharmacology, Aspm’s K.T.Patil. College of Pharmacy, Osmanabad, Post Box No.-56, Siddharth Nagar, Osmanabad, 413501(M.S.), IN
2 A.S.P.M’s K.T. Patil College of Pharmacy, Siddharth Nagar, Barshi Road, Osmanabad, (M.S.) 413501, IN
3 Appasaheb Birnale College of Pharmacy, Shivaji Nagar, Sangali (M.S.), IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 1 (2009), Pagination: 18-20Abstract
Hydro-alcoholic extract of bark of Orthosiphon stamnineus Benth (HAEOSB) was studied for its in-vivo anti-inflammatory potential using Carageenen induced rat paw edema and cotton pellet induced granuloma mehods. The result of study indicated that Hydro-alcoholic extract possess significant anti-inflammatory activity at doses 500 and 750 mg/kg.- Antimicrobial Activity of Saussurea lappa Clarke Roots
Abstract Views :148 |
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Authors
Affiliations
1 ASPM’s K.T.Patil College of Pharmacy , Siddharth Nagar, Osmanabad- 413501(M.S.), IN
2 Department of Pharmacognosy and Phytochemistry, K.L.E.S’s College of Pharmacy, Belgaum-590010, Karnataka, IN
3 Department of Pharmacognosy and Phytochemistry, A.S.P.M’s K. T. Patil College of Pharmacy, Osmanabad - 413501. Maharashtra, IN
1 ASPM’s K.T.Patil College of Pharmacy , Siddharth Nagar, Osmanabad- 413501(M.S.), IN
2 Department of Pharmacognosy and Phytochemistry, K.L.E.S’s College of Pharmacy, Belgaum-590010, Karnataka, IN
3 Department of Pharmacognosy and Phytochemistry, A.S.P.M’s K. T. Patil College of Pharmacy, Osmanabad - 413501. Maharashtra, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 1 (2009), Pagination: 51-53Abstract
The Antimicrobial potential of Saussurea lappa Clarke. against certain microorganisms was studied using agar diffusion method. The aqueous and ethanolic extract of S. lappa ischolar_mains significantly inhibited the growth of microorganisms as compared to standard bactericide and fungicide drugs. Diethyl ether fraction exhibited prominent fungicidal activity against Candida albicans. Gentamycin, Streptomycin and Fluconazole were used as positive controls.Keywords
Microorganisms, Candida albicans, Bactericide, Gentamycin, Saussurea lappa.- Synthesis and Biological Activities of Some Benzothiazole Derivatives
Abstract Views :129 |
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Authors
Affiliations
1 ASPM’s, K. T. Patil College of Pharmacy, Osmanabad-413501 (MS), IN
1 ASPM’s, K. T. Patil College of Pharmacy, Osmanabad-413501 (MS), IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 421-427Abstract
Substituted benzothiazoles have received considerable attention during last two decades as they are endowed with variety of biological activities and have wide range of therapeutic properties. A Literature survey indicates that benzothiazole derivatives possess different pharmacological and biological activities; which of most potent activity are anti-inflammatory and anti-bacterial activity. The starting product is 6-substituted-1, 3-benzothiazol-2-amine was prepared from 4-substituted anilines and potassium thiocyanate in one step. Substituted Benzothiazolyl-2-amines were reacted with chloroacetyl chloride to yield 2-chloro acetyl amino-6-substitued benzothiazoles, which were reacted with 2-mercaptobenzothiazole and 2-hydrazinobenzthiazole gave 2-(1,3-benzothiazol-2-yl thio)-N-(6-substitued-1,3-benzothiazol-2-yl) acetamides and 2-[2-(1,3-benzothiazol-2-yl)hydrazino]-N-(6-methyl-1,3-benzothiazol-2-yl) acetamides respectively. The synthesized compounds were characterized by elemental analysis and spectral data.Keywords
Benzothiazoles, Antibacterial, Antifungal.- Drug Design:An Emerging Era of Modern Pharmaceutical Medicines
Abstract Views :188 |
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Authors
Affiliations
1 ASPM’s K.T. Patil College of Pharmacy, Osmanabad-413501, IN
1 ASPM’s K.T. Patil College of Pharmacy, Osmanabad-413501, IN