Informatics Publishing Limited

C. Wijayasiriwardena , M. G. Chauhan , P. P. Sharma , S. K. Lahiri , M. B. Shah

Abstract

Objectives: To investigate anti-inflammatory activity of Delonix elata (D.elata) leaf, by carrageenan induced paw edema and cotton pellet granuloma models, along with the antioxidant potential underpinning its role as traditional medicine for joint disorders. Materials and methods: Methanol extract and its, ethyl acetate soluble and insoluble daughter fractions were evaluated for anti-inflammatory activity. Rats were divided into seven groups (n=6), including control and standard. Oral doses of methanol extract (100, 200 and 300mg/kg) and its daughter fractions (300mg/kg) were given to animals after carrageenan challenge. The best performing methanol extract was forwarded for cotton-pellet induced granuloma model. The same was also subjected to antioxidant assays like DPPH free radical scavenging activity, reducing power assay and nitric oxide scavenging activity. Moreover, isolation and HPTLC quantification of a marker compound was also attended from methanol extract derived ethyl acetate fraction. Results: In comparison to control, methanol extract of D. elata leaf at 300 mg/kg showed significant reduction in area under curve of rat paw edema in the later phases of inflammation (45.83%), which was comparable to that of standard (valdecoxib, 33.525%). The extract was also effective in producing 28.125% inhibition of granuloma formation which was comparable to that of standard (23.88%). Apart from nitric oxide scavenging assay (IC₅₀ 157.08μg/ml), the activity of methanol extract in other assays were not as significant as the respective standard drugs. Of the ethyl acetate soluble and insoluble fractions evaluated, both showed marginal reduction in paw edema. From the ethyl acetate fraction, luteolin was isolated as a marker compound and quantified by HPTLC. Conclusion: Methanol extract of D. elata leaf was found to be active in the last phase of paw edema at 300 mg/kg, compared to other doses and fractions. At the same dose it was found to have potent antioxidant capacity, which may play its role in reducing inflammation. The claims regarding anti-inflammatory activity of D. elata leaf can be considered valid as explicated by its methanol extract.

Keywords

Antioxidant, Delonix Elata, Edema, Inflammatory Joint Disorders, Leaf, Luteolin

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R. H. Gokani ¹, M. A. Rachchh ², S. K. Lahiri ³, D. D. Santani ⁴, M. B. Shah ³

Affiliations
1 “Shrikunj” 3-Archana Park, B/H Krishna Complex, University Road, Rajkot-360005, Gujarat, IN
2 Dept. of Pharmacognosy, S.J. Thakkar Pharmacy College, Rajkot, IN
3 Dept. of Pharmacognosy, L. M. College of Pharmacy, Ahmedabad, IN
4 Dept. of Pharmacology L. M. College of Pharmacy, Ahmedabad, IN

Abstract

Root of Premna integrifolia known under common name Arni/Agnimantha which is an important constituent of well known formulation, Dashmularistha used for various ailments. In the present study methanolic extract of the ischolar_mains was evaluated for its in-vitro antioxidant activity using the anti radical, superoxide scavenging, anti lipid peroxidation, hydroxyl radical scavenging and nitric oxide scavenging, assays. The extract showed significant anti-oxidant activity in all the assays. The study scientifically demonstrated the use of P. integrifolia as a potential source of natural antioxidant.

Keywords

P. integrifolia, Verbanaceae, Anti-Oxidant Activity.

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S. K. Lahiri ¹

Affiliations
1 Indian Standard Institution, Calcutta, IN

Abstract

Of all rolled steel sections railroad rail is subjected to the most rigorous service conditions. Exposed to atmospheric corrosion all the time and having no protective coating, it is subjected under constantly varying conditions of stresses of of all kinds, such as, high compression, bending stresses, combination of stresses, impact, vibration, friction and wear. It is a vital part of railroad operations and is a difficult section to roll. With the advancement of speed of travel, increase of axle load, use of different kinds of locomotives more and more has been expected of rail. In order to meet these requirements rail should have greatest possible transverse strength, adequate metal for wear, should have a wide base of fastening to the slippers and last but not the least, it should have the lightest section possible to effect economy.

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S. K. Lahiri ¹, S. Malhotra ², S. Mukhopadhyay ³, G. P. Srivastava ⁴

Affiliations
1 Control Instrumentation Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
2 Electromagnetic Applications and Instrumentation Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
3 Seismology Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
4 Tower 6, Flat 401, Sagar Darshan, Sector 18, Navi Mumbai 400 706, India

Abstract

A case study is presented here on the continued deve­lopment efforts at the Bhabha Atomic Research Centre on instrumented pipeline inspection gauge for Indian Oil Corporation Limited over the last two decades. A marvel of technology involving challenges of non-destructive testing techniques, mechanical, magnetism, electronics, data processing and analysis, operational safety requirements and portability, qualifications of the tools and characterization of defects with acceptable accuracy were achieved to be at par with the internationally available tools. These tools are being extensively deployed in the field. The homegrown technology for in-line inspection has brought down the cost of the tool and that of the services per kilometre. Different technologies are now being pursued to ensure that the in-line inspection work in the country is carried out in an ‘Atmanirbhar’ way.

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