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Nachiket, S. D.
- Solvent Free Synthesis and Biological Evaluation of 1, 5-Benzodiazepine
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS, 413736, IN
2 Department of Pharmaceutical Chemistry, SRES’s Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Maharashtra, 423601, IN
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS, 413736, IN
2 Department of Pharmaceutical Chemistry, SRES’s Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Maharashtra, 423601, IN
Source
Nano Science & Nano Technology: An Indian Journal, Vol 11, No 1 (2017), Pagination: 1-6Abstract
Number of substituted 1, 5-benzodiazepines are known for their biological importance like anti-bacterial, antifungal, anticancer, and anti-inflammatory activity. The present investigation is carried for the synthesis of certain substituted 1, 5-benzodiazepines and carried out their sedative activity. The title compounds have been synthesized from OPD reacts with substituted aryl aldehydes to give substituted 1, 5-benzodiazepines. The newly synthesized compounds have been characterized by IR, 1H NMR and CHN analysis. Selected compounds are screened for sedative activity in vivo using spontaneous locomotor activity model. Few of them exhibited promising activity.Keywords
1, 5-Benzodiazepines, Pharmacological Screening, Sedative Activity, Spontaneous Locomotor Activity, IR, 1H NMR, CHN Analysis.Full Text
References
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