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Markad, Ravi
- Simultaneous Quantification of Salbutamol and Theophylline by Validated Spectrophotometric Method in Tablet Dosage form
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Authors
Siddheshwar Ghale
1,
Prachi Kabra
1,
Ritu Kimbahune
2,
Ruchika Patel
1,
Ravi Markad
1,
L.V.G. Nargund
1
Affiliations
1 Department of Quality Assurance, Nargund College of Pharmacy, Dattatreyanagar, IInd Main, 100 Ft. Ring Road, BSK III stage, Bangalore -85.
2 Department of Quality Assurance, Al-Ameen College of Pharmacy, Hosur Road, Opp. Lal Bagh Main Gate, Bangalore-27
1 Department of Quality Assurance, Nargund College of Pharmacy, Dattatreyanagar, IInd Main, 100 Ft. Ring Road, BSK III stage, Bangalore -85.
2 Department of Quality Assurance, Al-Ameen College of Pharmacy, Hosur Road, Opp. Lal Bagh Main Gate, Bangalore-27
Source
Asian Journal of Research in Chemistry, Vol 6, No 3 (2013), Pagination: 200-203Abstract
In the present study, spectrophotometric method was developed and validated using multicomponent mode for simultaneous estimation of Salbutamol Sulphate and Theophylline in combined tablet dosage form. Distilled water was used as a solvent. Considering the absorption of both the analytes in the range of 200 nm - 320 nm, four wavelength of equal interval of 40 nm were selected such as 320 nm, 280 nm, 240 nm and 200 nm for analysis of these drugs. The mean percentage assay was found as 100.50% and 100.79% for Salbutamol Sulphate and Theophylline respectively. Results of analysis were validated statistically in accordance with ICH guidelines for accuracy and precision of the method. The results of recovery study were observed in the range of 93.26-99.24%. for Salbutamol Sulphate and 97.39-103.615% for Theophylline, While, the % RSD for precision study was observed less than 1 %. So, it can be concluded that, the developed method is simple, accurate, economical and easy to apply, making it suitable for routine analysis of Salbutamol Sulphate and Theophylline in tablet dosage form.Keywords
Salbutamol Sulphate, Theophylline, Multicomponent Spectroscopy
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