Informatics Publishing Limited

Tushar D. Sonawane ¹, Rajesh Z. Mujoriya ², Harsha N. Nandre ³

Affiliations
1 Torrent Pharmaceutical Ltd, Bhat Village, Gandhinagar, Gujarat, IN
2 Department of Pharmaceutics, Agnihotri College of Pharmacy, Wardha, IN
3 Department of Physics, KSM’s Pratap College, Amalner, IN

Abstract

The Review provides detail information regarding X-ray powder diffraction technique (XRPD). X-ray powder diffraction (XRPD) is innovative analytical technique used for determination of crystalline or amorphous nature of compound. XRPD technique is important for investigation of nanocrystalline form of the compound. XRPD techniques provide information about formation of polymorphs or hydrate under various environmental conditions. XRPD used in various fields and covered huge area of Academic and industrial research.

Keywords

XRPD, Crystalline, Amorphous, Solvate, Hydrate, Polymorphs.

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Tushar D. Sonawane ¹, Rajesh Z. Mujoriya ²

Affiliations
1 Torrent Pharmaceutical Ltd, Bhat Village, Gandhinager, Ahmedabad, IN
2 Agnihotri College of Pharmacy, Wardha, Maharashtra, IN

Abstract

The purpose of this study is to enhance solubility and dissolution rate of poorly water soluble drug, Different methods are used for solubility enhancement such as particle size reduction, complexation, Self emulsifying drug delivery, use of surfactant, out of that solid dispersion technique is used. Ketoconazole is used as a drug of choice for solubility enhancement. Solid dispersions were prepared by using hydrophilic carrier Polyethylene glycol 4000, Polyethylene glycol 6000 and urea. Drug carrier solid dispersions were prepared by solvent evaporation method. Prepared solid dispersions of ketoconazole was shows remarkable increase in the solubility and dissolution rate. Prepared solid dispersions were investigates for In-vitro dissolution study.

Keywords

Hydrophilic Carrier, Solvent Evaporation, Poorly Soluble Drugs, Ketoconazole.

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Rajesh Z. Mujoriya ¹

Affiliations
1 Agnihotri College of Pharmacy, Ramnagar, Wardha, M.H., IN

Abstract

Analytical method development followed by method validation is an important process in the drug discovery. Although the drug shows good potency, lack of validated analytical method will not allow the drug to enter into the market. This is to ensure the quality and safety of the drug. The main objective of this review is to give an idea about the old and novel techniques available for the analysis of drugs in their raw material and formulated forms, check the stability of the drugs in the presence of the excipients and other stress conditions experienced during their shelf life period. Analytical methods development and validation play important roles in the discovery, development and Manufacture of pharmaceuticals. Method development is the process of proving that an analytical method is acceptable for use to measure the concentration of an API in a specific compounded dosage form which allows simplified procedures to be employed to verify that an analysis procedure, accurately and consistently will deliver a reliable measurement of an active ingredient in a compounded preparation. The analytical method validation is essential for analytical method development and tested extensively for specificity, linearity, accuracy, precision, range, detection limit, quantization limit, and robustness. In summary, analytical method development and validation allows to confirm that an accurate and reliable potency measurement of a pharmaceutical preparation can be performed.

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