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Vadivu, R.
- Affinity Propagation Clustering with Background Knowledge Using Pair Wise Constraints
Abstract Views :181 |
PDF Views:2
Authors
Affiliations
1 Department of Computer Science & Engineering, Maharaja Engineering College for Women, Anna University, Chennai, IN
2 Department of Computer Science and Engineering, Anna University, Chennai, IN
1 Department of Computer Science & Engineering, Maharaja Engineering College for Women, Anna University, Chennai, IN
2 Department of Computer Science and Engineering, Anna University, Chennai, IN
Source
Data Mining and Knowledge Engineering, Vol 4, No 11 (2012), Pagination: 569-574Abstract
The pairwise constraints specifying whether a pair of samples should be grouped together or not have been successfully incorporated into the conventional clustering methods such as k-means and spectral clustering for the performance enhancement. Nevertheless, the issue of pairwise constraints has not been well studied in the recently proposed MMC (Maximum Margin Clustering), which extends the MMC in supervised learning for clustering and often shows a promising performance. In clustering process, semi-supervised learning is a class of machine learning techniques that make use of small amount of labeled and large amount of unlabeled data for training. This affinity propagation is aimed in making the effective clustering process by performing word wise comparison and overcomes the problem of overlapping that is encountered in K-mean and reduces the memory space required.Keywords
Affinity Propagation, Pair Wise Constraints, Semi Supervised Learning, Word Pair Process, MMC.
- Docking of Hematoporphyrin on Various Anticancer Drugs Targeting Enzymes
Abstract Views :256 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai, IN
2 Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai, IN
1 Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai, IN
2 Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai, IN
Source
Asian Journal of Pharmaceutical Research, Vol 6, No 3 (2016), Pagination: 123-130Abstract
The present study deals with docking of Hematoporphrin with various anticancer drugs targeting enzymes. The targets used were PDB-ID 2Y3I, PDB-ID 3OZZ, PDB-ID 3UEN and PDB-ID 4O33. Hematoporphyrin docked with these enzymes and interactions between the enzyme and compound were measured and compared with standard Paclitaxel. The study concluded that, the compound (Hematoporphyrin) isolated from plant were high interactions with PDB-ID 4O33 when compared to standard.Keywords
Docking, Hematoporphyrin, Paclitaxel, Protein Data Bank, Interactions.- Establishment of Pharmacognostical Standards for the Bark of Sterculia foetida linn
Abstract Views :160 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai-03
1 Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai-03
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 8, No 2 (2016), Pagination: 75-80Abstract
Pharmacognostical studies were carried out to identify and authenticate the bark of Sterculia foetida. Pharmacognostical studies were carried out in terms of macroscopic, microscopic and physiochemical analysis. The outer bark is grey in color and inner bark is buff coloured single quill and has fibrous texture. The characteristic microscopic features of bark were observed as cork, cortex, medullary rays, phloem parenchyma and sclerenchyma in the transverse section. The microscopical features of powdered bark showed the presence of lignified fibers, xylem vessels, stone cells, cortex and calcium oxalate crystals. Histochemical studies were done to identify and locate the active constituents present in the bark. Ash values, extractive values, swelling index, foaming index, loss on drying and foreign organic matter were also carried out in order to find out the quality and purity of the drug.Keywords
Sterculiafoetida, Macroscopy, Microscopy, Histochemical studies and Physio-chemical constants.- A Review on Sterculia foetida Linn
Abstract Views :167 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai-03, IN
1 Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai-03, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 7, No 4 (2015), Pagination: 239-244Abstract
Sterculia foetida Linn., (Sterculiaceae) known as Wild Almond or Java olive is an attractive umbrella shaped spreading tree. Traditionally, leaves as well as the seeds have important medicinal values as they contain Sterculic acid(53%) as a constituent which has proven to have interesting pharmacological applications such as anti-inflammatory, anti-diabetic and anti-obesity potentials. The tree yield edible seeds rich in fat (30-36%) and protein 11.4%. Traditionally leaves and bark are used as aperient, diaphoretic, diuretic and also used in the treatment of rheumatism, obesity, gonorrhoea, dropsy, skin diseases etc,. The plant is rich in fatty acids and flavonoids. This review summarizes the overall research of phytochemical and pharmacological activities of Sterculia foetida in the recent years.Keywords
Sterculia foetida, Sterculiaceae, Review, Phytochemical, Pharmacological.- Pharmacognostical Standardization of Leaves of Ravenala madagascariensis Sonn.
Abstract Views :167 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai, Tamilnadu, IN
1 Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai, Tamilnadu, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 4 (2010), Pagination: 288-292Abstract
Standardization was carried out on the basis of detailed botanical evaluation of the leaves which includes morphology and microscopy as well as WHO recommended physico-chemical studies. The results of the standardization may throw a immense light on the botanical identity of the leaves Ravenala madagascariensis Sonn., which may furnish a basis of judging the authenticity of the plant and also to differentiate the drug from its adulterants and other species.
Ravenala madagascariensis Sonn., (Strelitziaceae), also known as Visirivazhai in Tamil, is a native of Madagascar, widely cultivated for its distinctive habit in tropical and subtropical regions. In addition to its ornamental nature, this tree has been widely used in traditional medicine for the treatment of diabetes and kidney stone problems. The seeds are reported to be antiseptic. The leaves of Ravenala madagascariensis Sonn., have close resemblance with Musa leaf. Hence pharmacognostical standardization will contribute to the differentiation of Ravenala madagascariensis Sonn. leaves from that of Musa paradisiaca. The anatomy of leaf showed squarish upper epidermis. The lower epidermis was stomatiferous. Cyclocytic stomata, druses, raphides, mesophyll with tannin bodies, lobed sclereids remain the characteristic features of the leaf microscopy. Physicochemical parameters were evaluated and fluorescence analysis were carried out.
Thus the study employs the correct identification of standardization of the drug in crude form.
Keywords
Ravenala madagascariensis Sonn., Standardization, Botanical, Physico-Chemical Constants.- Colon Targeted Drug Delivery System of Phytoconstituents
Abstract Views :422 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacognosy, Madras Medical College, Chennai, IN
1 Department of Pharmacognosy, Madras Medical College, Chennai, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3144-3150Abstract
Now a day’s world health organization encourage, recommends and promotes traditional, herbal remedies in health care sciences, because these drugs low in cost, easily available and are safe. The main advantage of using phytoconstituents is free from adverse effects where none of the medication can do. However, the physiochemical properties such as poor permeation, poor solubility and non- targeting at the active site creates a barriers which hinders its therapeutic efficacy. So, targeted drug delivery strategies are employed to overcome these barriers and provide uniform drug targeting at the active site in desired concentration and improved therapeutic efficacy. These day’s colonic diseases are commonly seen and needs lifelong medical attention. Herbal medicines can play vital role in the treatment of colonic diseases like ulcerative colitis, intestinal bowel syndrome, colon cancer and Crohn’s disease. This review article discusses in brief, introduction to targeted drug delivery, factors influence the drug targeting and approaches for enhancing the therapeutic potential of phytoconstituents having wide biological activities.Keywords
Colon Drug Delivery, Factors, Approach, Phytoconstituents.References
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