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Srikanth, R.
- Molecular Docking Study of Bark-derived Components of Cinnamomum Cassia on Aldose Reductase
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Authors
Affiliations
1 Dept. of Zoology, Presidency College, Chennai–600005, IN
2 Dept. of Biotechnology, Sri Venkateswara College of Engineering, Chennai-602105, IN
1 Dept. of Zoology, Presidency College, Chennai–600005, IN
2 Dept. of Biotechnology, Sri Venkateswara College of Engineering, Chennai-602105, IN
Source
Indian Journal of Science and Technology, Vol 3, No 10 (2010), Pagination: 1081-1088Abstract
Aldose reductase (AR) is an enzyme associated with retinopathy of both type 1 and type 2 diabetic patients. AR is inhibited by giving chemical drugs to prevent diabetic retinopathy, but is associated with deleterious side effects. Compounds isolated from plants are safer than chemical drugs and have a lot of potential. In the present study, three components viz., cinnamaldehyde, cinnamic acid and cinnamyl alcohol derived from the bark of Cinnamomum cassia were used to evaluate their efficiency in inhibiting AR activity. For this, the AR protein structure database was downloaded from PDB and its pictorial database was downloaded from PDBsum. Structural visualization of AR was done by RasMol. Using Q-SiteFinder, prediction of ligand binding site was done. The three dimensional structures of inhibitors viz., cinnamaldehyde, cinnamic acid and cinnamyl alcohol were downloaded from ChemSketch. Docking studies were carried out using ArgusLab software. Docking studies of cinnamaldehyde, cinnamic acid and cinnamyl alcohol against AR was undertaken to gain insight into the binding mode of the investigated compounds at the active site of AR. All compounds were found to be active against AR as indicated by docking results; the best being cinnamaldehyde. Results suggest that cinnamaldehyde, cinnamic acid and cinnamyl alcohol should be evaluated further for therapeutic use in combination with other diabetic drugs. Further, this may be confirmed by drug trials in animal models to find out the optimum dose and its efficiency in inhibiting AR activity to treat diabetic related complicationsKeywords
Diabetes, Aldose Reductase, Cinnamon, Molecular DockingFull Text
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- Soft Strongly g-Closed Sets
Abstract Views :209 |
PDF Views:0
Authors
Affiliations
1 Department of Mathematics, Srinivasa Ramanujan Centre, SASTRA University, Kumbakonam - 612 001, Tamil Nadu, IN
2 Department of Mathematics, SASTRA University, Thanjavur - 613 401, Tamil Nadu, IN
1 Department of Mathematics, Srinivasa Ramanujan Centre, SASTRA University, Kumbakonam - 612 001, Tamil Nadu, IN
2 Department of Mathematics, SASTRA University, Thanjavur - 613 401, Tamil Nadu, IN
Source
Indian Journal of Science and Technology, Vol 8, No 18 (2015), Pagination:Abstract
Background/Objectives: The objective of the present paper is to define soft strongly g-closed sets and soft strongly g-open sets in soft topological spaces and study their basic properties. Methods: Here we used the concept of soft closure of soft interior and soft open sets to define soft strongly g-closed sets. Findings: The relationship between soft strongly g-closed sets and other existing sets has been investigated. Further the union, intersection of two soft strongly g-closed sets have been obtained. The authors discussed the complements of soft strongly g-closed sets in the last section. Conclusion/Improvements: In future, the varieties of new continuous mappings and separation axioms based on these sets may be introduced and the future research may be undertaken in this direction.Keywords
Soft Strongly g-closed Sets, Soft Strongly g-open Sets, Soft g-closed Sets, Soft g-open Sets, Soft rg-closed Sets, Soft rg-open SetsFull Text
- Why India Needs a National Electricity Council
Abstract Views :318 |
PDF Views:90
Authors
Affiliations
1 National Institute of Advanced Studies, Bengaluru 560 012, IN
1 National Institute of Advanced Studies, Bengaluru 560 012, IN
Source
Current Science, Vol 113, No 07 (2017), Pagination: 1233-1241Abstract
India is the third largest electricity generator in the world after China and USA. India has already committed to its Nationally Determined Contributions submitted to the United Nations Framework Convention on Climate Change for the period 2021–2030, which inter alia, includes a commitment, to achieve about 40% cumulative electric power installed capacity from non-fossil fuel-based energy resources by 2030 with the help of technology transfer and low-cost international finance. However, India’s power sector is facing several major challenges as it makes a transition to a more environment-friendly energy mix. Since electricity is a concurrent subject as per the Constitution of India, there is an urgent need to create an empowered National Electricity Council (NEC) with pooled sovereignty to realize the goal – ‘One Nation-One Grid-One Price’. The proposed NEC will facilitate the evolution of a vibrant and self-sustaining power sector in India in a timely manner.Keywords
Coal Power Plants, Electricity (Amendment) Bill, Energy and Environment, Optimal Energy Mix, Stressed Assets.Full Text
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- India’s Steel Industry – Quo Vadis
Abstract Views :421 |
PDF Views:85
Authors
Affiliations
1 National Institute of Advanced Studies, Bengaluru 560 012, IN
1 National Institute of Advanced Studies, Bengaluru 560 012, IN
Source
Current Science, Vol 114, No 02 (2018), Pagination: 243-244Abstract
Steel is one of the most important man-made materials with a huge diversity in use ranging from a paper clip to an aircraft carrier. Modern infrastructure and buildings are increasingly using steel due to its properties of strength, aesthetics, ease of use and cost. For a developing country like India, steel consumption is also linked to economic growth. Just over a hundred years ago, Fredrick Upcott, Chairman of the Indian Railways, promised to ‘eat every pound of steel rail’ made in India to British specifications. Fast forward to financial year (FY) 17, India is the third largest producer in the world producing 101 Mt of finished steel, only behind Japan and China. The steel sector contributes 2% to India’s Gross Domestic Product (GDP), and employs 5 lakh people directly and 20 lakh people indirectly. This sector is estimated to have an output multiplier effect of 1.4x on GDP and 6.8x on employment in India.Full Text
- Role of Electric Mobility in a Sustainable, and Energy-Secure Future for India
Abstract Views :269 |
PDF Views:85
Authors
Affiliations
1 National Institute of Advanced Studies, Bengaluru 560 012, IN
1 National Institute of Advanced Studies, Bengaluru 560 012, IN
Source
Current Science, Vol 114, No 04 (2018), Pagination: 732-739Abstract
Within the next decade, a set of four low-carbon technologies – LEDs, solar energy, wind energy, and electric vehicles are set to reconfigure the dynamics of several industries. While India is making significant progress in the first three, we hardly see any electric vehicles on our roads, though the National Electric Mobility Mission Plan (NEMMP-2020) was launched by the Government of India on 9 January 2013 with the aspiration of selling 6–7 million new electric vehicles in 2020 to achieve liquid fuel savings of 2.2–2.5 million tonnes, along with substantial lowering of vehicular emissions and a decrease in CO2 emissions. In addition to these vital benefits, acceleration of electric mobility in India will also lead to higher job creation in manufacturing. In this article, key recommendations are proposed to accelerate the progress of electric vehicles as a much-needed move towards a more sustainable and energy-secure future for India and a healthier life for Indians.Keywords
Battery Storage, Electric Vehicles, Energy Security, Low-Carbon Economy.Full Text
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