Informatics Publishing Limited

R. Punasiya ¹, A. Joshi ², S. Gupta ², J. Punasiya ²

Affiliations
1 G.R.Y. Institute of Pharmacy, Borawan, Khargone (M.P.), IN
2 GRY Institute of Pharmacy, Borawan, Khargone (M.P.) 451228, IN

Abstract

There is considerable interest in the skin as a site of drug application both for local and systemic effect. However, the skin, in particular the stratum corneum, poses a formidable barrier to drug penetration thereby limiting topical and transdermal bioavailability. Skin penetration enhancement techniques have been developed to improve bioavailability and increase the range of drugs for which topical and transdermal delivery is a viable option. This review describes enhancement techniques based on drug/vehicle optimization such as drug selection, prodrugs and ion-pairs, supersaturated drug solutions, eutectic systems, complexation, liposome, vesicles and particles. Enhancement via modification of the stratum corneum by hydration, chemical enhancers acting on the structure of the stratum corneum lipids and keratin, partitioning and solubility effects are also discussed. The mechanism of action of penetration enhancer's, retarders and their potential for clinical application is described.

Keywords

Transdermal Delivery, Skin Penetration, Enhancer, Retarder.

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R. Punasiya ¹, A. Joshi ², S. Yadav ², K. Patidar ², K. Kapse ²

Affiliations
1 G.R.Y. Institute of Pharmacy, Borawan, Khargone (M.P.), IN
2 GRY Institute of Pharmacy, Borawan, Khargone (M.P.) 451228, IN

Abstract

Human and veterinary medicines have not been so well succeeded in order to achieve their goals concerned with the treatment of various types of infections. The antibiotic activity of Punica granatum Linn. (Fresh leaves) extract was evaluated by the agar diffusion method and agar disc diffusion to determine the zone of inhibition. The extract of P. granatum presented potential antibiotic action over all the assayed strains, forming 10 to 36 mm diameter inhibition zones. This paper's results claim the effectiveness of the extract of P. granatum as a potential antibacterial agent and display the significance of evaluating new substances with antimicrobial potential, which can contribute to alternative therapeutics for medicine.

Keywords

Punica granatum, Aqueous Extract, Methanol Extract and Antibiotic Activity.

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