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- N. S. Dighe
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Saudagar, R. B.
- Chikungunya Disease: A Review
Abstract Views :262 |
PDF Views:2
Authors
N. S. Dighe
1,
S. R. Pattan
1,
S. B . Dighe
1,
S. B. Bhawar
1,
R. B. Saudagar
2,
V. M. Gaware
1,
M. B. Hole
1,
V. B. Tambe
1
Affiliations
1 Pravara Rural College of Pharmacy, Pravaranagar, A/P-Loni (413736), Tal- Rahata, Dist.-Ahmednagar, Maharashtra, IN
2 R. G. Sapakal College of Pharmacy, Nasik, Maharashtra, IN
1 Pravara Rural College of Pharmacy, Pravaranagar, A/P-Loni (413736), Tal- Rahata, Dist.-Ahmednagar, Maharashtra, IN
2 R. G. Sapakal College of Pharmacy, Nasik, Maharashtra, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 1 (2009), Pagination: 7-12Abstract
Chikungunya virus is an insect-borne virus, of the genus Alphavirus, that is transmitted to humans by virus-carrying Aedes mosquitoes. The virus causes an illness with symptoms similar to dengue fever with an acute febrile phase of the illness which lasts only two to five days. Infection can affect the nervous system or the musculo-skeletal system. General symptoms include fever, headache, maculopapular rash, arthralgia, myalgia, photophobia and lymphadenopathy. Virus isolation provides the most definitive diagnosis. The most effective means of prevention are protection against contact with the disease-carrying mosquitoes and mosquito control. NSAIDs, chloroquine and DNA vaccine are the effective medicines.Keywords
Chikungunya, Aedes Mosquitoes, Fever, Chloroquine.
References
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- Robinson MC. "An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952-53. I. Clinical features". Trans. R. Soc. Trop. Med. Hyg. 1955; 49 (1): 28–32.
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- A Neurodegenerative Disorder-Alzheimer Disease: A Treatise
Abstract Views :365 |
PDF Views:2
Authors
Affiliations
1 Kalyani Charitable Trust's R.G. Sapkal College of Pharmacy, Sapkal Knowledge Hub. Anjaneri, Trimbakeshwar, Nashik 422 212, IN
1 Kalyani Charitable Trust's R.G. Sapkal College of Pharmacy, Sapkal Knowledge Hub. Anjaneri, Trimbakeshwar, Nashik 422 212, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 4 (2010), Pagination: 268-273Abstract
Alzheimer disease (AD), though not a life threatening disease but increase the morbidity rate of an individual. It can be very well correlated with the retrograde amnesia. But specifically as it is encountered in elder subjects, it is represented as Senile Dementia. The earliest observable symptoms are often mistakenly thought to be 'age-related' concerns, or manifestations of stress. In the early stages, the most commonly recognized symptom is memory loss, such as difficulty in remembering recently learned facts. When a doctor or physician has been notified, and AD is suspected, the diagnosis is usually confirmed with behavioral assessments and cognitive tests, often followed by a brain scan if available. As the disease advances, symptoms include confusion, irritability and aggression, mood swings, language breakdown and long-term memory loss is also assumed. Gradually, bodily functions are lost, ultimately leading to death. It is found that some plaque is present in the brain. One area of clinical research is focused on treating the underlying disease pathology by reduction of amyloid beta levels is a common target of compounds under investigation. Immunotherapy or vaccination for the amyloid protein is one treatment modality under study. Unlike preventative vaccination, the putative therapy would be used to treat people already diagnosed.Keywords
Alzheimer Disease, β-amyloid.References
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- Role of Retinoids in Treatment of Alzheimer's Disease
Abstract Views :232 |
PDF Views:2
Authors
Affiliations
1 KCT's Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik-13, IN
1 KCT's Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik-13, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 3 (2012), Pagination: 144-149Abstract
Alzheimers disease very basically is characterized by the loss of the cognitive functions. β-amyloid is a major histopathological hallmark of Alzheimer's disease (AD). The disease is characterized by extracellular neuritic plaque composed of fibrillar-amyloid peptide and intracellular neurofibrillary tangles containing hyperphosphorylated tau. The peptides are generated by successive proteolysis of beta amyloid precursor protein, a large transmembrane glycoprotein that is initially cleaved by the site amyloid precursor protein cleaving enzyme -1 and subsequently by gamma secretase in the transmembrane domain. Retinoic acid is active metabolite of Vitamin A. Deprivation of Vitamin A results in amyloid-β accumulation, loss of hippocampal long term potentiation and memory deficit, all of which are hall mark of Alzheimers disease. Here we focused a role of retinoic acid on different pathophysiological features of Alzheimers disease. Retinoic acid may play an active role in treating neurodegenerative disorder. Retinoids appear to normalize many pathological states, and clinical side effects presently reported are mostly not serious except for retinoic acid syndrome.Keywords
Alzheimers, Retinoic Acid, Vitamin A, Amyloid-β, Retinoid X Receptor(RXR).References
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- Formulation and Evaluation of Mucoadhesive Buccal Patch of Saxagliptin Hydrochloride
Abstract Views :347 |
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Authors
Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 4 (2016), Pagination: 237-247Abstract
Buccal route offers the advantage of avoiding first pass metabolism. Saxagliptin Hydrochloride in conventional dosage form is extensively metabolized by the liver. The Saxagliptin Hydrochloride is antidiabetic agent used in the treatment of type-II Diabetes mellitus. The oral bioavailability is 67%. The half-life of saxagliptin Hydrochloride is 2.5 hours and it undergoes hepatic metabolism. So, in order to improve the bioavailability and efficacy, we have prepared buccal patches of saxagliptin Hydrochloride. HPMC is one the polymers which is having good mucoadhesive property so therefore various formulations were developed by using release rate controlling HPMC K100M and Eudragit RL-100 by Solvent Casting technique. In addition to this propylene glycol - 400 was used as plasticizer and permeation enhancer respectively. Drug-excipients interaction study was proven if any. Buccal patches were characterized for number of parameters like Mechanical properties and , weight uniformity, thickness, Percent moisture loss, folding endurance, swelling index, surface pH, drug content uniformity, in-vitro residence time, drug-excipients interaction study, Mucoadhesive strength and in-vitro drug release study. 32 full factorial design was employed to study the effect of independent variables. The response of design was analyzed using Design Expert® trial version 7.0.0; and the tools of the software were used to draw Contour plot and 3D plot. On the basis of the software analysis, formulation F7 was selected as optimized formulation and evaluated for independent parameters. Optimized formulation showed 98.35 ± 0.52% dug release upto 6 hrs. Optimized formulation fulfils all necessary attributes required for Buccal Patch and can become a promising alternative to present marketed tablet of Saxagliptin Hydrochloride.Keywords
Buccal Patches, Saxagliptin Hydrochloride (SXG HCL), Hydroxypropylmethyl Cellulose (HPMC), and Eudragit RL-100.- Microsphere:A Review
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Authors
Affiliations
1 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 7, No 1 (2016), Pagination: 27-37Abstract
Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers having a particle size ranging from 1-1000 μm. The range of Techniques for the preparation of microspheres offers a variety of opportunities to control aspects of drug administration and enhance the therapeutic efficacy of a given drug. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. One such approach is using microspheres as carriers for drugs also known as microparticles. It is the reliable means to deliver the drug to the target site with specificity, if modified, and to maintain the desired concentration at the site of interest. Microspheres received much attention not only for prolonged release, but also for targeting of anticancer drugs. In future by combining various other strategies, microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene and genetic materials, safe, targeted and effective in vivo delivery and supplements as miniature versions of diseased organ and tissues in the body.Keywords
Microspheres, Controlled Release, Therapeutic Efficacy, Novel Drug Delivery.- Liquisolid Technology: A Review
Abstract Views :208 |
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Authors
Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjineri, Nashik, IN
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjineri, Nashik, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 3 (2016), Pagination: 161-166Abstract
Liquisolid system is a novel concept of drug delivery via oral route. Solubility is the phenomenon of dissolution of solid in liquid phase and is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response. Poorly water soluble compound’s oral administration often require high doses in order to reach therapeutic plasma concentrations because insufficient dissolution rate of the drug is the limiting factor in the oral bioavailability and one of the most challenging aspects of drug development. Design of this technique was according to new mathematical model proposed by Spireas et al. The drug is dissolved or dispersed in suitable non-volatile solvent and this liquid medication is converted to free flow powder by using carrier and coating material. To this suitable excipients were added and tabletting by direct compression. In this case, even though the drug is in a solid dosage form, it is held within the powder substrate in solution or, in a solubilized, almost molecularly dispersed state, which contributes to the enhanced drug dissolution properties. Large scale production of fabricated drug on commercial level. Succesful liquisolid tablet is a determination of optimal flowable liquid retention.Keywords
Liquisolid System, Dissolution of Solid.- Review on Solubility Enhancement Techniques
Abstract Views :189 |
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Authors
Affiliations
1 Department of Quality Assurance Techniques, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213 Maharashtra, IN
2 Department of Chemistry, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, IN
1 Department of Quality Assurance Techniques, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213 Maharashtra, IN
2 Department of Chemistry, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, IN
Source
Asian Journal of Pharmaceutical Research, Vol 6, No 3 (2016), Pagination: 147-152Abstract
Absorption process is develop in biological system to getting required organic and inorganic chemicals in to systemic circulation and maintain bioavailability. The bioavailability issue can be due to insufficient solubility or permeability. Most compounds face the solubility problems. Hence, with the advancement of chemical science, the need of development of pharmaceutical technologies is also increasing and it depend upon drug to drug. The drug exhibit very poor aqueous solubility the rate at which drug dissolve in gastro intestinal tract and exhibit rate limiting step. Oral route is the most desirable and preferred method of administering therapeutic agents for their systemic effect On the basis of solubility, drugs are classified into four classes of the BCS classification. Solubility challenges are faced in the Class II and Class IV of the BCS system. To improve solubility and bioavailability of poorly soluble drug we use various methods or techniques. Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include physical and chemical modifications of drug and other methods like particle size reduction, crystal engineering, salt formation, solid dispersion, use of surfactant, complexation, and so forth. Selection of solubility improving method depends on drug property, site of absorption, and required dosage form characteristics.Keywords
Bioavailability, Novel Methods, Solubility, BCS Class.- UV-Spectroscopic Estimation and Validation of Drotaverine Concentration in Bulk and Dosage Form
Abstract Views :218 |
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Authors
Affiliations
1 Department of Quality Assurance, Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik, IN
1 Department of Quality Assurance, Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 6, No 3 (2016), Pagination: 188-190Abstract
A simple, accurate, precise, and sensitive a highly selective ultra violet spectrophotometric method has been developed for the validation and estimation in bulk and dosage form. It shows maximum absorbance 286 nm. Beer-Lambert's was obeyed in the concentration range of in the range of 15-55μg/ml. The method was successfully validated in accordance to ICH guideline for accuracy, precision, linearity and robustness. The linear regression analysis data for calibration plots showed good linear relationship and obtain correlation factor 0.9927 for Drotaverine. Thus method was successfully applied for routine analysis of Drotaverine in bulk samples.Keywords
Drotaverine, ICH, UV- Spectroscopy, Accuracy, Precision.- Revolutionized Topico-Systemic Era:Transdermal Drug Delivery System
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Authors
Affiliations
1 Department of Pharmaceutics, KCT’s R.G.S. College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, KCT’s R.G.S. College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 6, No 2 (2015), Pagination: 66-76Abstract
At present oral route is one of the most widely accepted route of drug administration, but owing to its drawbacks of low bioavailability as a result of hepatic first pass metabolism a new system was introduced for controlled delivery of drug. Transdermal drug delivery has been accepted as a potential non-invasive route of drug administration, with advantages of prolonged therapeutic action, decreased side effects, easy use and better patient compliance. Transdermal drug delivery system (TDDS) involves drug transport to viable epidermal and/or dermal tissue of the skin for local therapeutic effect while a major fraction of drug is transported into systemic blood circulation. Transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. An advantage over other routes is that the patch provides a controlled release of medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive. The present review describes various types of Transdermal patches, permeation strategies, their methods of preparation, evaluation techniques and their future trends.Keywords
Transdermal Drug Delivery System, Transdermal Patch.- An overview on Trends and Development of Niosomes as Drug Delivery
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Authors
Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjenari, Nashik-422213, Maharashtra, IN
2 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjenari, Nashik-422213, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjenari, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjenari, Nashik-422213, Maharashtra, IN
2 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjenari, Nashik-422213, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjenari, Nashik-422213, Maharashtra, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 7, No 2 (2016), Pagination: 79-85Abstract
Niosomes or non ionic surfactant are microscopic lamellar structures which may be unilamellar or multilamellar. These are amphiphillic in nature, hence capable of entrapping both hydrophilic and lipophilic drugs for their controlled delivery. Niosomes are formulated by hydration of the lipid by the aqueous phase which may be either single surfactant or a mixture of surfactant with cholesterol. Stability of niosomes is greater as compared with other novel drug delivery techniques. Niosomes are widely used for delivery of many drugs especially in treatment of life threatening diseases, site specific targeting can be achieved with niosomes, and they are also used in diagnostic imaging purpose. This study is based upon the recent advances by which niosomes can be formulated and their application in controlled and effective delivery of variousdrugs. Niosomes represent a promising drug delivery module. They present a structure similar to liposome and hence they can represent alternative vesicular systems with respect to liposomes, due to the niosome ability to encapsulate different type of drugs within their multi environmental structure. Niosomes are thoughts to be better candidate's drug delivery as compared to liposomes due to various factors like cost, stability etc. Various types of drug deliveries can be possible using niosomes like targeting, ophthalmic, topical, parenteral, etc.Keywords
Niosomes, Drug Delivery, Routes of Administrations, Applications.- Formulation and Evaluation of Transferosomal Gel of Isotretinoin for Severe Acne
Abstract Views :255 |
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Authors
Affiliations
1 R. G. Sapkal College of Pharmacy, Nashik, Maharashtra, IN
2 Parul Institute of Pharmacy, Vadodara, Gujarat, IN
1 R. G. Sapkal College of Pharmacy, Nashik, Maharashtra, IN
2 Parul Institute of Pharmacy, Vadodara, Gujarat, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 5, No 2 (2014), Pagination: 39-45Abstract
Isotretinoin (13-cis-Retinoic acid) is a poor water soluble drug, commonly used in the treatment of severe cases of acne. The aim of present work was to formulate isotretinoin in the form of transferosomal gel and sustain the drug release, enhance the drug availability at the site of action and minimize the side effects by the use of formulations containing Phospholipon 90 H and surfactant. The transfersomes were formulated by lipid film hydration technique using Rotary vacuum Evaporator. The prepared transfersomes were optimized for type and concentration of edge activator and converted into suitable gel formulation then it was evaluated for their characteristics. The prepared transferosomes were evaluated for Particle size, Size distribution, Deformability, % Entrapment efficiency and % Drug release kinetic modeling for 24 hrs. The excipients compatibility was performed by using Differential scanning calorimetry and it was found compatible with each other. The vesicular surface morphology was studied using Transmission electron microscopy (TEM). Then gel was evaluated for characteristics like pH, viscosity and spreadability, skin irritation study and skin permeation study. The stability studies performed for 6 months at 4°C and room temperature as per ICH guideline. In vitro drug release studies showed desirable results based on linearity, the drug permeation data fit well to Higuchi equation plot (R2=0.943) indicating the diffusion rate limited drug permeation mechanism was found as Fickian diffusion. Transferosomal gel prepared showed all the desired properties and complied within the range of results.Keywords
Isotretinoin, Transfersomes, DSC, Skin Irritation Study.- An Overview:Aloe vera
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Authors
Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 5, No 2 (2014), Pagination: 62-67Abstract
Aloe vera is a herb disseminated all through the world. Aloe vera is one of the plant animal varieties which have numerous uses to humanity. It has been broadly utilized for a long time as an option solution furthermore as a corrective item. Due to its restoring, calming and mending properties, it has been utilized for different therapeutic diseases like peptic ulcers, digestive issues, skin bothering and different skin sores. An examination of writing uncovered some eminent pharmacological exercises of the plant, for example, mitigating, antiviral and antitumor, anxiolytic, hostile to maturing impact, sterile, improve safe framework, hypoglycemic, cytotoxic, antiulcer and antidiabetic impacts, antibacterial impact, cell reinforcement, cardiovascular impact, wound healing, antioxidant, antiseptic. Aloe vera is one of the plant animal categories which has various uses to humanity. It has been broadly utilized for ages as an option drug furthermore as an issue item. Likewise, it has been discovered to be useful in oral issues like gingivitis and periodontitis and different parasitic and viral infections. However, the employments of this plant are well known to people since quite a while now, still its uses in dentistry are not broad. The survey here underlines the incredible criticalness of this ordinarily discovered plant.Keywords
Aloe vera, Pharmacological Activities, Chemical Constituents.- A Review:Floatable Gastroretentive Drug Delivery System
Abstract Views :289 |
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Authors
Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Asian Journal of Pharmaceutical Research, Vol 5, No 1 (2015), Pagination: 51-60Abstract
In the late years, exploratory and innovative progressions have been made in the innovative work of novel medication conveyance frameworks by overcoming physiological inconveniences, for example, short gastric habitation times and capricious gastric purging times. A few methodologies are as of now used in the prolongation of the gastric habitation times, including floating medication conveyance frameworks, swelling and stretching frameworks, polymeric bioadhesive frameworks, adjusted shape frameworks, high-thickness frameworks and other deferred gastric exhausting gadgets. The administration of sickness through solution is entering another period in which developing number of novel medication conveyance frameworks are continuously utilized and are accessible for helpful utilization. Oral maintained discharge gastroretentive measurements structures offer numerous favorable circumstances for medications with assimilation from upper parts of gastrointestinal tract and for those acting mainly in the stomach, enhancing the bioavailability of the pharmaceutical. Floating Gastroretentive Drug Delivery Systems (FGRDDS) is one among the gastroretentive measurements structures used to accomplish delayed gastric living arrangement time. The reason for composing this audit on skimming medication conveyance frameworks (FGRDDS) was to arrange the late writing with unique concentrate on the important instrument of floatation to accomplish gastric maintenance. The late advancements of FGRDDS including the physiological and definition variables influencing gastric maintenance, methodologies to plan single-unit and numerous unit coasting frameworks, and their arrangement and detailing angles are secured in point of interest. This survey likewise compresses the in-vitro strategies, in vivo studies to assess the execution and application of floating frameworks, and applications of these frameworks.Keywords
Floating Gastroretentive Drug Delivery System (FGRDDS), Single Unit, Multiple Units, Recent Trends, In Vitro-In Vivo Evaluation.- Simultaneous Estimation of Drotaverine HCl and Nimesulide in a Tablet Formulation by Absorbance Ratio Method
Abstract Views :229 |
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, MVP College of Pharmacy, University of Pune, Maharashtra, Nashik 422002, IN
2 Department of Pharmaceutical Chemistry, M.G.V’s Pharmacy College (Pune University), Mumbai, IN
3 KCT’s R. G. Sapkal College of Pharmacy, Anjineri, Nashik, Maharashtra, IN
1 Department of Pharmaceutical Chemistry, MVP College of Pharmacy, University of Pune, Maharashtra, Nashik 422002, IN
2 Department of Pharmaceutical Chemistry, M.G.V’s Pharmacy College (Pune University), Mumbai, IN
3 KCT’s R. G. Sapkal College of Pharmacy, Anjineri, Nashik, Maharashtra, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 4, No 2 (2014), Pagination: 78-81Abstract
Spectrophotometric method were proposed for the simultaneous analysis of Drotaverine HCl and Nimesulide in a tablet formulationby absorbance ratio method at 278 nm (isoabsorptive point) and 304 nm(λ max of Drotaverine HCl ) with mean percentage recovery 98.25%±0.66 and 100.5%±0.95, respectively. Beer's law for both methods was obeyed in the concentration range 5-25μg/ml of drotaverine HCl and Nimesulide respectively. The suggested method were successfully applied for the analysis of the two drugs in their pharmaceutical formulation. The obtained results were statistically agreed with those obtained by the reported method.Keywords
Drotaverine HCl, Nimesulide, Absorbance Ratio Method.- A Comprehensive Review on Gastro-Retentive Floating Drug Delivery Systems
Abstract Views :312 |
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Authors
Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Asian Journal of Pharmaceutical Research, Vol 5, No 4 (2015), Pagination: 211-220Abstract
In recent years scientific and technological advancements have been made in the research and development of novel drug delivery systems by overcoming physiological troubles such as short gastric residence times and unpredictable gastric emptying times. Floating drug delivery systems are designed to prolong the gastric residence time after oral administration, at particular site and controlling the release of drug especially useful for achieving controlled plasma level as well as improving bioavailability. Floating drug delivery systems are the systems which are retained in the stomach for a longer period of time and there by improve the bioavailability of drug. The single unit dosage forms have the disadvantage of a release all or nothing during emptying process while the multiple unit particulate system pass through the GIT to avoid the vagaries of gastric emptying and thus release the drug more uniformly. The uniform distribution of these multiple unit dosage forms along the GIT could result in more reproducible drug absorption and reduced risk of local irritation. The purpose of designing multiple-unit dosage form is to develop a reliable formulation that has all the advantages of a single-unit form and also is devoid of any of the above mentioned disadvantages of single unit formulations. This review explains briefly about advantages, disadvantages, mechanism, types, factors, evaluation and application of these systems.Keywords
Gastro-Retentive Floating Drug Delivery System, Advantages, Disadvantages, Mechanism, Evaluation.- Fast Dissolving Oral Films
Abstract Views :178 |
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Authors
Affiliations
1 Department of Pharmaceutics, KCT’S RGS College of Pharmacy, Anjaneri, Nashik 422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, IN
1 Department of Pharmaceutics, KCT’S RGS College of Pharmacy, Anjaneri, Nashik 422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, IN
Source
Asian Journal of Pharmaceutical Research, Vol 6, No 1 (2016), Pagination: 56-58Abstract
The oral route is most popular route for the administration of therapeutic agents because of the low cost of therapy and ease of administration lead to high levels of patient compliance. The most popular oral solid dosage forms are tablets and capsules. Oral fast dissolving films is relatively a new dosage form in which thin film is prepared using hydrophilic polymers which rapidly dissolves on tongue or Buccal cavity. The films overcome the fear of chocking. An ideal film should have the properties like pleasant taste, high stability, ease of handling and administration, no water necessary for application. Fast dissolving oral delivery systems are solid dosage forms, which disintegrate or dissolve within 1 min when placed in the mouth without drinking water or chewing.Keywords
Fast Dissolving Film, Film Forming Polymer, Solvent Casting Technique, Patented Technology.- Glimpse of Floating Drug Delivery in Pharmaceutical Formulations:A Review
Abstract Views :206 |
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Authors
Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Asian Journal of Pharmaceutical Research, Vol 6, No 1 (2016), Pagination: 31-38Abstract
In recent years the novel technology of floating drug delivery system formulations are designed for the new drugs for oral targeted drug delivery. The drugs are delivered by conventional dosage forms are having very short residence time, but the drugs which are act in stomach are have more residence time. The floating drug delivery systems are of particular interest for drugs that are locally active and narrow absorption window in stomach. Systems which are retained in the stomach for a longer period of time and there by improve the bioavailability of drugs. In this review the various advantages are given which are very important for controlled drug delivery system. Floating drug delivery systems have a bulk density less than gastric fluids. When the system floats on gastric contents the drug is released slowly at the desire rate from system. The polymers are suitable for floating drug delivery systems are covered in this review.Keywords
Floating Drug Delivery System, Mechanism and types of FDDS, Evaluation of FDDS.- A Review on Gold Nanoparticles
Abstract Views :307 |
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjenari, Nashik, Maharashtra, IN
2 Department of Quality Assurance Techniques, R.G. Sapkal College of Pharmacy, Anjenari, Nashik, Maharashtra, IN
1 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjenari, Nashik, Maharashtra, IN
2 Department of Quality Assurance Techniques, R.G. Sapkal College of Pharmacy, Anjenari, Nashik, Maharashtra, IN
Source
Asian Journal of Pharmaceutical Research, Vol 6, No 1 (2016), Pagination: 45-48Abstract
This review is focused essentially on the types and applications of gold nanoparticles in the field of medicine and targeted drug delivery. Nanotechnology has become one of the most interesting and advanced areas of research in this field. Among nanoparticles, gold nanoparticles demonstrate special advantages in this field due to their unique properties, small size and high surface area-to-volume ratio. These particles have been widely used in various biomedical applications and drug delivery systems due to their inert nature, stability, high dispersity, non-cytotoxicity and biocompatibility. Gold nanoparticles can be functionalized with protein, peptides and nucleic acid. So these have a great application not only in bio sensing drugs but also in drug, gene and protein delivery.Keywords
Gold Nanoparticle, Nanotechnology, Advantages, Applications.- Formulation, Evaluation and Comparative Study of Zolmitriptan Mouth Dissolving Tablet
Abstract Views :225 |
PDF Views:1
Authors
Affiliations
1 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
1 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 6, No 4 (2016), Pagination: 207-216Abstract
Migraine is likely due to local cranial vasodilation and to release of sensory neuropeptide through nerve ending in the trigeminal system. Zolmitriptan is Serotonin 5-HT1D receptor agonist. It gives relief from pain, headache, and other symptoms of migraine including nausea, vomiting and sensitivity to light/ sound. In this study, mouth dissolving tablets were prepared by direct compression method. In the present work efforts have been made to formulation, evaluation and comparative study of Zolmitriptan mouth dissolving tablet by using direct compression method. Release profile of F-7 having 40% Croscarmellose sodium (disintegrant) and 13.3% Microcrystalline cellulose (suspending agent) in direct compression method was found to have maximum release of 99.24 %. The drug release from all batches was found to be concentration dependent. Hence, the formulation of F-7 fulfills the objective of the present study.Keywords
Zolmitriptan, Direct Compression, Mouth Dissolving Tablet, Croscarmellose Sodium, Microcrystalline Cellulose.- Formulation Development and Evaluation of Topical Film-Forming Lotion Containing Butenafine Hydrochloride
Abstract Views :210 |
PDF Views:1
Authors
R. B. Saudagar
1,
S. Samuel
2
Affiliations
1 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik: 422213, Maharashtra, IN
2 Department of Quality Assurance Techniques, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik : 422213, Maharashtra, IN
1 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik: 422213, Maharashtra, IN
2 Department of Quality Assurance Techniques, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik : 422213, Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 6, No 4 (2016), Pagination: 238-248Abstract
Many agents are applied to the skin deliberately with beneficial outcomes. Conventional formulations intended for topical and dermatological administration of drugs such as creams, foams, gels and lotions are considered to reside for a relatively short period of time at the targeted site. The localized treatment of body tissues, diseases and wounds requires that the particular pharmaceutical component be maintained at the site of treatment for an effective period of time. Sweat, clothing, movements and getting washed away easily on contact with water are some of the problems that have limited the effectiveness and residence time of conventional topical formulations for treatment of fungal infections of skin. This necessitates longer treatment duration. Hence, a composition that adheres to skin surface afflicted and provides localized delivery of an antifungal agent is needed. The present work aims at designing and formulating a 'film- forming lotion' which on application will form a thin transparent film on the skin. Eudragit RL 100 and HPMC K4M was used to form a matrix film. The formulations were prepared using 32 full factorial design. They were tested for drying time, drug release, antifungal activity, skin irritation and stability studies. The gel was characterised for pH, viscosity, drug content, effective dosage volume and mechanical properties of the film formed after application; bioadhesion and water vapour permeability were also tested. All the formulations showed results within acceptable range for various tests. The optimized formulation showed drug release of 99.64% and antifungal activity in terms of efficacy as 98.72%. Such a formulation can be claimed to decrease duration of therapy, will be more accepted by the patients and be a breakthrough in treating fungal infections of the skin.Keywords
Butenafine Hydrochloride, Film-Forming Lotion, Eudragit Rl100 And HPMC K4M, Fungal Skin Infection.- A Review on Microsponge a Novel Drug Delivery System
Abstract Views :313 |
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Authors
Affiliations
1 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik- 422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik- 422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 6, No 1 (2016), Pagination: 51-57Abstract
Conventional topical formulations are intended to work on the surface of the skin. Normally, upon application such formulations release their active ingredients and producing a highly concentrated layer of active ingredient that is quickly absorbed. Therefore, need exists for a system to increase the amount of time that an active ingredient is present either on skin surface as well as within the epidermis, at the same time, minimizing its transdermal penetration in the body. Recently, microsponge delivery system (MDS) has been successively addressed for the controlled release of drugs onto the epidermis with assurance that the drug remains chiefly localized and does not enter the systemic circulation in major amounts. MDS is a unique technology for the controlled release of topical agents, also use for oral as well as biopharmaceuticals (peptides, proteins and DNA based therapeutics) drug delivery. This review article covers methods of preparation, release mechanism, characterization and applications of microsponge delivery system with patent information and marketed formulations.- Recent Research on Matrix Tablets for Controlled Release-A Review
Abstract Views :189 |
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Authors
Affiliations
1 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik- 422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik- 422213, Maharashtra, IN
1 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik- 422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik- 422213, Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 5, No 4 (2015), Pagination: 214-221Abstract
Oral drug delivery is the leading and the oldest segment of the total drug delivery system in the market. It is the greatest growing and most favored route for drug administration so oral controlled release of drugs becomes a very promising approach for drugs that having the shorter half-life and high dose frequency. Matrix tablets are an interesting option and new break through when developing an oral controlled release drugs delivery system. The use of various classes of release rate retardants like hydrophilic, hydrophobic, polymers and their degradation products are focused also. Release of drugs from matrices formulated with hydrophobic polymers is slower than from matrices formulated with hydrophilic Polymers.
The present article contains a brief review of various formulation approaches used in controlled release drug delivery systems, the role of polymers in the controlled delivery of many fast release drugs and the mechanism of drug release from these polymeric matrices. The oral controlled release system of many drugs has been known to be an essential part of formulation development in drug delivery systems. It has been the focus of pharmaceutical research for many years due to its various advantages over conventional dosage forms. Administering the drug for release in the blood at a controlled rate, to maintain relatively constant drug levels in plasma over a controlled period of time, can overcome many problems associated with conventional dosage forms. The applicability of these dosage forms is due to reduction in the frequencies of drug dosing, which lead to patient convenience and compliance. In addition, a reduction of wide fluctuations in plasma drug concentration peak can be obtained. As a result, toxicity and poor efficacy can be avoided, especially with drugs of narrow therapeutic indices. Such problems, associated with conventional dosage forms of many drugs, can be overcome by using controlled release drug delivery systems, to deliver the drug for absorption at a controlled rate over an extended period of time. The controlled release dosage form should be tailored so that variations in the components can lead to predictable alterations in the drug release profiles. Various controlled release drug delivery systems have different mechanisms to control the drug release rate, such as the osmotic pump, ion exchange resin and matrix systems which have been widely utilized as controlled release drug delivery approaches. Besides, polymers have often been used in the components of controlled release drug delivery systems.
Keywords
Introduction Matrix Tablet, Hydrophobic Polymer, Hydrophilic Polymer, Controlled Release Matrix System.- An Overview on Trends and Developments in Liposome-As Drug Delivery System
Abstract Views :178 |
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Authors
Affiliations
1 Department of Pharmaceutics, KCT'S R.G. Sapkal College of Pharmacy, Anjenari, Dist. Nashik-422212, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, KCT'S R.G. Sapkal College of Pharmacy, Anjenari, Dist. Nashik-422212, Maharashtra, IN
1 Department of Pharmaceutics, KCT'S R.G. Sapkal College of Pharmacy, Anjenari, Dist. Nashik-422212, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, KCT'S R.G. Sapkal College of Pharmacy, Anjenari, Dist. Nashik-422212, Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 5, No 4 (2015), Pagination: 231-237Abstract
Liposomes, spherical vesicles consisting of one or more phospholipids bilayers, were first described in mid 60s by Banghum and coworkers. Since then, liposomes have made their way to the market. Liposomes are highly versatile structures for researcher's therapeutic and analytical applications. The insight gained from clinical use of liposome drug delivery systems can now be integrated to design liposomes targeted to tissues and cells with or without expression of target recognition molecules on liposomes membranes. Enhanced safety and heightened efficacy have been achieved for wide range of drug classes, including antitumor agents, antiviral, antifungal, antimicrobial, vaccines and gene therapeutics. This review summaries exclusively scalable industrial method of preparation of liposomes, marketed preparation of liposomes and analysis of liposomes. An additional point of view was taken to regulatory concerning liposomal drug formulations based on FDA and EMEA documents.Keywords
Liposomes, Preparation Methods, Characteristics, Analysis.- Ethosomes: Novel Noninvasive carrier for Transdermal Drug Delivery
Abstract Views :175 |
PDF Views:1
Authors
R. B. Saudagar
1,
S. Samuel
2
Affiliations
1 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik: 422213, Maharashtra, IN
2 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik : 422213, Maharashtra, IN
1 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik: 422213, Maharashtra, IN
2 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik : 422213, Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 6, No 2 (2016), Pagination: 135-138Abstract
Ethosomes are noninvasive delivery carriers that enable drugs to reach the deep skin layers and/or the systemic circulation. Although ethosomal systems are conceptually sophisticated, they are characterized by simplicity in their preparation, safety, and efficacy a combination that can highly expand their application. Ethosomes are soft, malleable vesicles tailored for enhanced delivery of active agents. This article reviews various aspect of ethosomes including their preparation, characterization, potential advantages and their applications in drug delivery. Because of their unique structure, ethosomes are able to encapsulate and deliver through the skin highly lipophilic molecules such as cannabinoids, testosterone, and minoxidil, as well as cationic drugs such as propranolol, trihexyphenidil, Cyclosporine A, insulin, Salbutamol etc. Ethosomes provides a number of important benefits including improving the drug's efficacy, enhancing patient compliance and comfort and reducing the total cost of treatment. Enhanced delivery of bioactive molecules through the skin and cellular membranes by means of an ethosomal carrier opens numerous challenges and opportunities for the research and future development of novel improved therapies.Keywords
Ethosomes,ttransdermal Drug Delivery, Noninvasive, Carriers.- Kleptomania: An Overview
Abstract Views :199 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmaceutics, KCT’s R.G.S. College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra
2 Department of Pharmaceutics, KCT’s R.G.S. College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, KCT’s R.G.S. College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra
2 Department of Pharmaceutics, KCT’s R.G.S. College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 6, No 2 (2016), Pagination: 127-130Abstract
Kleptomania is an impulse control disorder characterised by emotional or behavioural self-control. Patient fails to resist impulses to steal items although not required for personal use or for monetary value. The symptoms include repeated theft of objects not needed, increasing tension before committing theft and relief after theft. The present article gives account on causes of disorder, its symptoms, history, different approaches to treat disorder and various hormonal imbalance associated with it. Various antidepressant drugs have been in use for the treatment along with psychotherapy.Keywords
Kleptomania, Impulse Control Disorder, Selective Serotonin Reuptake Inhibitors.- Lyophilization Technique:A Review
Abstract Views :198 |
PDF Views:0
Authors
Affiliations
1 Department of Quality Assurance Technique, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
1 Department of Quality Assurance Technique, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 4 (2016), Pagination: 269-276Abstract
While arriving new century, lyophilization in the pharmaceutical field has been subjected to ongoing development and steady expansion. This review objectives to highlight recent advances but also to discuss further challenges in lyophilization. At first, the three major steps of a typical lyophilization process, namely freezing, primary drying, and secondary drying. Additionally, a general description of the essential components and their function in a lyophilizer is given. The principle of lyophilization; heat transfer and mass transfer also described. The expanded range of pharmaceutical applications based on lyophilization is brief. Now a days, lyophilization has also gained importance for the preservation and stabilization of biological products, hormones, proteins, nucleic acid based. This review deals with the solubliser, stabilizer and cryoprotectant used in various lyophilized formulations of the molecules. The role of solubliser, stabilizer and cryoprotectant has been discussed.Keywords
Lyophilization, Importance of Lyophilization Process, Methods of Lyophilization Process, Excipients Used in Lyophilized Formulation.- Review on Resealed Erythrocyte
Abstract Views :172 |
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Authors
Affiliations
1 Department of Quality Assurance Technique, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
1 Department of Quality Assurance Technique, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 4 (2016), Pagination: 261-268Abstract
Erythrocytes, also known as red blood cells, and have been extensively studied for their potential carrier capabilities for the delivery of drugs. Such drug-loaded carrier erythrocytes are prepared simply by collecting blood samples from the organism of interest, separating erythrocytes from plasma, entrapping drug in the erythrocytes, and resealing the resultant cellular carriers, these carriers are called resealed erythrocytes. Among the various carriers used for targeting drugs to various body tissues, the cellular carriers meet several criteria desirable in clinical applications, among the most important being biocompatibility of carrier and its degradation products. Carrier erythrocytes, resealed erythrocytes loaded by a drug or other therapeutic agents, have been exploited extensively in recent years for both temporally and spatially controlled delivery of a wide variety of drugs and other bioactive agents owing to their remarkable degree of biocompatibility, biodegradability and a series of other potential advantages. Leucocytes, platelets, erythrocytes, nano erythrocytes, hepatocytes, and fibroblast etc. have been proposed as cellular carrier systems. Among these, the erythrocytes have been the most investigated and have found to possess greater potential in drug delivery. In this review article, the potential applications of erythrocytes in drug delivery have been reviewed with a particular stress on the studies and laboratory experiences on successful erythrocyte loading and characterization of the different classes of biopharmaceuticals.Keywords
Resealed Erythrocytes, Drug Targeting, Isolation, Drug Loading Method, Characterization Methods and Applications.- Microsponges
Abstract Views :226 |
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Authors
Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 2 (2016), Pagination: 77-84Abstract
The drug delivery technology landscape has become highly competitive and rapidly evolving. More and more developments in delivery systems are being integrated to optimize the efficacy and cost-effectiveness of the therapy. Peptides, proteins and DNA-based therapeutics cannot be effectively delivered by conventional means. To control the delivery rate of active agents to a predetermined site in human body has been one of the biggest challenges faced by drug industry. Controlled release of drugs onto the epidermis with assurance that the drug remains primarily localized and does not enter the systemic circulation in significant amounts is an area of research that is successively done by the Microsponge delivery system. This review covers the advantages of Microsponges, their formulation and applications in pharmaceutical field.Keywords
Microsponge, Controlled Release, Topical Drug Delivery, Oral Drug Delivery, Liquid-Liquid Suspension Polymerization.- Current Scenario of Global and Indian Pharmaceutical Marketing and Management
Abstract Views :223 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 2 (2016), Pagination: 95-100Abstract
The world pharmaceutical industry has been changing profoundly in the last decade. Intensive globalization, increased competitiveness and the fight for global market shares create new challenges for pharmaceutical companies. Fast globalization definitively reinforces the consolidation of the world Pharmaceutical industry . The current shift in the marketing strategy is work by multinational Pharmaceutical Companies. It is now High - end development that is being carried out by leading companies. And, increasingly, other companies are finding themselves competing against, or working with, new innovation - based companies. My study focuses on objectives, importance, levels, theories, functions and types of pharmaceutical management and also pharmaceutical marketing, difference between general marketing and pharmaceutical marketing. Also study the overlook on Global Pharma Industry and Indian Pharma Industry. In this study the top 50 companies in 2009 and 2014 year are listed out. Also OTC segments and Pharmaceutical Policy are included in this article.Keywords
Objectives, Importance, Functions, Difference between General Marketing and Pharmaceutical Marketing, Top 50 Companies in 2009 and 2014, OTC, Pharmaceutical Policy.- Superdisintegrants:A Review
Abstract Views :178 |
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Authors
Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 2 (2016), Pagination: 107-112Abstract
Disintegrants are the substances that causes the rapid disintegration of the capsules or tablets into smaller particles that dissolves more rapidly than in the absence of the disintegrants. On the other hand superdisintegrants, are used to improve the efficacy of solid dosage forms. This is achieved by decreasing the disintegration time which in turn enhances drug dissolution rate. Superdisintegrants categories such as synthetic, semi-synthetic, natural and coprocessed blends etc. They are used in mouth dissolving tablet as well as conventional tablet to overcome the limitations of this dosage form. Superdisintegrants are generally used at a low conc. in the solid dosage form. The present review comprises the various kinds of Superdisintegrants like natural and synthetic which are being used in the formulation.Keywords
Superdisintegrants, Disintegrants, Fast Release, Swelling, Wetting.- Granulation Techniques
Abstract Views :218 |
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Authors
Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 5, No 4 (2015), Pagination: 203-215Abstract
Granulation is one of the most important unit operation in the production of pharmaceutical oral dosage forms. Granulation is defined as the size enlargement process in which fine and smaller particle are aggregated to form strong and stable particles called granules. Granulation process improves flow compressibility and content uniformity of powders this technique helps to achieve improved yields with tablet defects , high productivity along with reduced down time the present review mainly focused on granulation techniques and the advantages and disadvantages of the process.Keywords
Granulation, Pharmaceutical Dosage Forms, Improved Yields.- Bilayer Floating Technology:An Innovative Approach
Abstract Views :185 |
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Authors
Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 1 (2016), Pagination: 37-44Abstract
The recent patented literature has concluded that there is an increasing interest in the novel dosage forms which retained in stomach for a longer period of time. Bilayer floating drug delivery system is new era for development of controlled release formulation. Bilayer floating drug delivery system is combined principle of bilayer technology as well as floating tablet is suitable for two incompatible drugs. The dosage form contains one sustain release layer and other is immediate layer. The immediate release layer is used to maintain dose. The floating dosage form can be prepared as tablet, capsule by adding suitable ingredients as well as adding gas generating agents.Keywords
Gastroretentive Dosage Forms, Bilayer Floating Drug Delivery System, Immediate Layer, Control Release Layer.- Brain Targeting Drug Delivery System: A Review
Abstract Views :176 |
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Authors
Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik- 422003, IN
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik- 422003, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 5, No 4 (2015), Pagination: 247-252Abstract
The Overall prevalence rate for CNS pathology has demonstrated that approximately 1.5 billion people under going from disorders of central nervous system. The most distressing fact about delivery of drugs to the CNS is the presence of blood brain barrier that have a tendency to impair the drug distribution and denotes the major impediment for the development of CNS drugs. Neuropeptides and many drugs which are hydrophilic in nature, possibly will encompass the intricacy while passing the blood brain barrier. The net amount of delivered drug (medicinal agent) and its capability to gain access to the pertinent target sites are the main considering points for CNS drug development. In order to distribute the drugs into the CNS via passing the blood brain barrier, many new emerging approaches have been developed for example Magnetic drug targeting, chemical delivery Systems, Drug carrier systems (antibodies, liposomes or Nanoparticles). Among drug carrier system, Nanoparticles exhibit an impressive attention in the field of targeted drug delivery system because of possessing solid colloidal particles with a size range between 1- 1000nm. Gradual drug release reduced peripheral toxicity and potential totarget specific brain sites by crossing the blood brain barrier are major benefits contributed by Nanoparticles. In this review we will discuss the methodologies for targeting the brain site.Keywords
Brain Barrier, Drug Delivery to Brain, Nanotechnology, Colloidal Drug Carriers.- VDevelopment and Validation of Spectrophotometric Method for Determination of Azelaic Acid
Abstract Views :253 |
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Authors
Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 5, No 2 (2015), Pagination: 1-3Abstract
In these studies describes a simple, accurate, precise and cost effective UV-visible spectrophotometric method for the estimation of Azelaic acid in pure and pharmaceutical formulations. The method is based on the measurement of absorbance of Azelaic acid solution in Phosphate buffer pH 6.8 at 204nm in the wavelength range of 200-400nm. The method obeys Beer's Lambert's law in the selected concentration range10-50 μg/ml in selected media. The slope, intercept and correlation coefficient were also calculated. Results of percentage recovery study shows that the method was not affected by the presence of common excipients in tablets. The parameters like linearity, precision, accuracy, sensitivity study i.e. limit of detection and limit of quantitation were studied according to International Conference on Harmonization (ICH) guidelines. The developed method was validated in terms of accuracy, precision, linearity, limit of detection and limit of quantitation which proves suitability of proposed method for routine estimation of Azelaic acid in pure and pharmaceutical formulations.Keywords
UV-Visible Spectrophotometer, Method Development, Azelaic Acid.- A Review:Pulsatile Drug Delivery System
Abstract Views :181 |
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Authors
Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 3 (2016), Pagination: 221-227Abstract
Pulsatile drug delivery system are gaining a lot of importance as these system deliver the drug at specific time as per the pathophysiological need of disease ,resulting in improved patient compliance and therapeutic efficiency. Disease where in PDDS are promising include asthama, peptic ulcer, arthritis, cardio vascular disease, peptic ulcer, attention deficit syndrome in children and hypercholesteromia. PDDS can be classified in time controlled system where the drug controlled primarily by the delivery system, stimuli induced PDDS in which release is controlled by the stimuli, like the ph or enzyme present in the intestinal tract or enzyme present in drug delivery system and externally regulated system where release is programmed by external stimuli like magnetism, ultrasound, electric effect and irradiation. The current article focuses on the disease requiring PDDS, methodologies involved for the existing system, recent update and PDDS product currently available in the market.- An Overview a Novel Trend in Drug Delivery:Niosomes
Abstract Views :155 |
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Authors
Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 3 (2016), Pagination: 211-217Abstract
Niosomes are non-ionic surfactant formation of vesicles by hydrating mixture of cholesterol and other lipids with or without incorporation. They are vesicular system that can be used as carriers of amphiphilic and lipophilic drugs. Niosomes are biodegradable, biocompatible, nonimmunogenic and exhibit flexibility in their structural characterization. Niosomes are preferred over liposomes because the former exhibit high chemical stability and economy. Different novel approaches used for delivering these drugs include liposomes, microspheres, nanotechnology, microemulision antibody loaded drug delivery, implantable pumps and niosomes. Niosomes are widely studied as an alternative to liposomes. They improve the therapeutic performance of the drug molecules by delayed clearance from the circulation, protecting drug from biological environment and restricting effects to target cells. This review article focuses on the advantages, disadvantages, preparation methods, factors affecting, characterizations, invitro methods, drug release kinetics, and application of niosomes.Keywords
Niosomes, Vesicles, Biological Environment, Composition.- An Overview on Sustain Release Matrix Drug Delivery System
Abstract Views :188 |
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Authors
Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 2 (2016), Pagination: 154-160Abstract
The oral route is the most frequently used route for the administration of drugs. Many of the pharmaceutical dosage form are formulated as sustained release dosage form to retard the release of a therapeutic agent such that its appearance in the systemic circulation is prolonged and its plasma profile is sustained in duration. Tablets offer the lowest cost approach to sustained and controlled release dosage forms. Matrix tablets serves as an important tool for oral extended- release dosage forms. Hence, problems like patient compliance, drug targeting, local side effects, frequent administration and fluctuations in blood concentration levels. Conventional drug delivery systems are known to provide a prompt release of drug or immediate release drug product. Such immediate release products result in relatively rapid drug absorption and onset of accompanying pharmacodynamic effects. Hence, change in the operation is a suitable and optimized way to make the some drug more effective by slight alteration in the drug delivery. Pharmaceutical industries and academic laboratories have been focused on development of novel drug delivery system or modified release dosage form rather investigation and development of new drug. Advance in technology have resulted in novel modified release dosage form. In contrast to conventional form, modified release products provide either delayed release or extended release of drug.Keywords
Hydrophilic and Hydrophobic Polymers, Matrix Tablet, Sustained Release Matrix Type Drug Delivery.- Microemulsion:A Current Review
Abstract Views :211 |
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Authors
Affiliations
1 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Analysis, R.G. Sapkal, College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Analysis, R.G. Sapkal, College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 2 (2016), Pagination: 161-170Abstract
Microemulsions, which has considerable potential to act as a drug delivery system is becoming the area of interest for the pharmaceutical scientist. In pharmaceutical fields, the interest in microemulsion is increasing and, thus, they are applied to various administered routes. Being thermodynamically stable, these microemulsions are composed of an aqueous and an oil phase along with the surfactants. An understanding of the physicochemical and biopharmaceutical characteristics of microemulsion will provide guidance for the designing of their formulation. Besides the understanding of the formation and its characterization this article gives provides the knowledge of construction of the phase diagram of the microemulsion. This article also emphasis the recent developments and future discussions. Developments for poorly soluble drugs of microemulsion are also included in this review.Keywords
Microemulsion, Structure, Advantage, Application.- Nanocrystal Drug Delivery System:A Review
Abstract Views :198 |
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Authors
Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik, 422003, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik, 422003, IN
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik, 422003, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik, 422003, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 2 (2016), Pagination: 122-126Abstract
Nanotechnology is the science in which the particle having the size below 1000nm.Theimportance of nanotechnology in drug delivery is in the concept and ability to manipulate molecules and supramolecular structures for producing devices with programmed functions. One of the major application areas of nanotechnology in pharmacy is nanoparticular drug delivery system. Preparation of nanocrystals to improve the solubility of poorly water- soluble drug for oral delivery is also one of the important applications. Drug nanocrystals are crystals with a size in the nanometre nanoparticle with a crystalline character .The use of drug Nanocrystals is an universal formulation approach to increase the therapeutic performance of these drugs in any rout of administration.Keywords
Nanocrystal, Top Down, Bottom Up, Application.- Glimpse of Floating Drug Delivery in Pharmaceutical Formulations:A Review
Abstract Views :191 |
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Authors
Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 2 (2016), Pagination: 147-153Abstract
In recent years the novel technology of floating drug delivery system formulations are designed for the new drugs for oral targeted drug delivery. The drugs are delivered by conventional dosage forms are having very short residence time, but the drugs which are act in stomach are have more residence time. The floating drug delivery systems are of particular interest for drugs drugs that are locally active and narrow absorption window in stomach. System which are retained in the stomach for a longer period of time and there by improve the bioavailability of drugs. In this review the various advantages are given which are very important for controlled drug delivery system. Floating drug delivery system have a bulk density less than gastric fluids. When the system floats on gastric contents the drug is released slowly at the desire rate from system. The polymers are suitable for floating drug delivery system are covered in this review.Keywords
Floating Drug Delivery System, Mechanism and Types of FDDS, Evaluation of FDDS.- In- Situ Nasal Gel: A Review
Abstract Views :158 |
PDF Views:1
Authors
Affiliations
1 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjenari, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjenari, Nashik-422213, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, R.G.Sapkal College of Pharmacy, Anjenari, Nashik-422213, Maharashtra, IN
1 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjenari, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjenari, Nashik-422213, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, R.G.Sapkal College of Pharmacy, Anjenari, Nashik-422213, Maharashtra, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 7, No 4 (2015), Pagination: 285-293Abstract
Nasal therapy also called "Nasya Karma" has been recognized form of treatment in the Ayurvedic. System of Indian Medicine. Nowadays many drugs have better systemic bioavailability through nasal route as compared to oral administration. The nose is also considered an attractive route for needle-free vaccination and for systemic drug delivery, especially when rapid absorption and effect are desired. The nasal delivery is a feasible alternative to oral or parenteral administration for some drug because of the high permeability of the nasal epithelium, rapid drug absorption across this membrane and avidance of first pass metabolism. Prolonged drug delivery can be achieved by various new dosage forms like in-situ gel. In-situ forming polymeric formulation are drug delivery system that is in sol form before administration in the body, but once administered, undergoes gelation in-situ to form a gel. In-situ nasal drug delivery system is the type of mucoadhesive drug delivery system. Now a days insitu gel has been used as vehicle for the drug delivery of the drug for both local treatment and systemic effect. In-situ nasal gel drug delivery system is advantageous over the conventional drug delivery system like sustained and prolonged release of drug, reduced frequency of administration, improved patient compliance and comfort.Keywords
Nasal Drug Delivery, Nasal In-Situ Gel, Mucoadhesive Drug Delivery System.- Anti-Infective Agents in the Management of Periodontal Disease:A Review
Abstract Views :179 |
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Authors
Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 7, No 1 (2015), Pagination: 82-89Abstract
Systemic anti-infective agents are progressively utilized as a part of the treatment of periodontal contaminations. Whilst these medications are utilized basically on an experimental premise, a few doctors battle that discerning utilization of anti-infective ought to be the standard because of their wide ill-use and worldwide development of antiinfective safe living beings.
This is an audit of the standards and balanced anti-infective treatment, treatment objectives, drug conveyance courses and different anti-toxins utilized as a part of the administration of periodontal infections. The accessible information demonstrate, all in all, that mechanical periodontal treatment alone is satisfactory to enhance or determination the clinical condition as a rule, however adjunctive anti-infective agents, delivered systemically, can improve the impact of help in particular circumstances. This is especially valid for forceful periodontitis in patients with summed up systemic ailment that may influence host safety, and in the event of poor reaction to customary mechanical treatment. This article gives a redesign on systemic anti-infective treatment for the treatment of periodontitis.
Keywords
Anti-Infective Agents, Periodontitis, Metronidazole, Tetracycline, Clindamycin.- Formulation Development of Ketoconazole Ophthalmic Formulation
Abstract Views :228 |
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Authors
Affiliations
1 Department of Quality Assurance Techniques, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Quality Assurance Techniques, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 5, No 6 (2013), Pagination: 303-310Abstract
The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid precorneal elimination of drug may be overcome by the use of ophthalmic gel systems. The purpose of the present study was to develop ophthalmic gel formulations of ketoconazole. Intraocular delivery of topically applied drugs such as ketoconazole is hampered by elimination of the solution due to tear turnover, so an mucoadhesive gel was formulated. Ketoconazole gels were prepared using sodium carboxymethylcellulose (NaCMC) as a mucoadhesive polymer and xanthan gum as a viscosity increasing agent. Gels were evaluated for various parameters like appearance, pH, drug content, gel strength, bioadhesion, viscosity, In-vitro drug release, isotonisity, sterility, antifungal activity, ocular irritancy and stability studies. The gel strength, bioadhesion and isotonisity shown quality parameter for ophthalmic formulation. The optimized formulation containing 1% w/v Na CMC and 0.2% w/v xanthan gum have shown 97.66% drug release up to 8 hrs. This is sufficient for antifungal activity. Diffusion studies have shown that a Korsmeyers-peppas is the best-fit model. This study found that an optimized formulation having improved viscosity and better mucoadhesive property may improve the bioavaibility of ocular administration of ketoconazole in gel form and can be alternative to the conventionally administered oral formulation and effectively used to prolong residence time.Keywords
Ophthalmic Drug Delivery, Bioavaibility, Mucoadhesive Polymer, Fungal Keratitis.- An Overview:Acne Vulgaris
Abstract Views :175 |
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Authors
Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 7, No 2 (2015), Pagination: 156-160Abstract
Acne vulgaris is a standout amongst the most widely recognized skin issue of pilosebaceous follicle described by papules, knobs, growths, comedones, pustules and regularly scars essentially scattered on the face, midsection and upper back. Pimple inflammation is a typical skin ailment that includes individual of all ages. Skin inflammation is delivered by the gram positive anaerobic microorganism (Propionibacterium acnes) and perceived as discharge framing microbes. Diverse parts of restorative plants and dermatological medications are utilized for the treatment of skin inflammation. In topical specialists; benzoyl peroxide, anti-infection agents, retinoids, and so on are the backbone of treatment; can be given in combination. While systemic treatment incorporates oral anti-microbials, hormonal therapy, and isotretinoin, contingent on the need of patients it must be chosen. Physical treatment in the type of injury evacuation, photograph help is likewise useful in few of them. Since different old and new topical and systemic specialists are accessible to treat acne vulgaris, it at some point confound treating dermatologist.Keywords
Acne Vulgaris, Propionibacterium Acnes, Staphylococcus Epidermidis.- An Ethnopharmacology of Trichopus zeylanicus Gaertn
Abstract Views :149 |
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Authors
Affiliations
1 KCT’S R.G. Sapkal College of Pharmacy, Anjaneri, Nashik 422 213, IN
2 JKK Nataraja College of Pharmacy, Komarapalyam, Namakal, TN, IN
1 KCT’S R.G. Sapkal College of Pharmacy, Anjaneri, Nashik 422 213, IN
2 JKK Nataraja College of Pharmacy, Komarapalyam, Namakal, TN, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 5, No 5 (2013), Pagination: 258-262Abstract
Trichopus zeylanicus Gaertn is a perennial herb belongs to the family Trichopodaceae popularly known as "Arogyapacha" or 'Arokyapachilai" in Malayalam literally meaning "the green that gives strength". A critical survey of the Ayurveda classics, suggests that the 'Arogyappacha' may be the divine 'Varahi'described by Sushruta. Geographically the plant is available in Agasthyar hills in the Western Ghats, Kerala, Singapore, Sri Lanka, Thailand and the Southwestern Ghats Mountains of South India. The herb grows on sandy soil near rivers and stream in shady places in low land and intermediate altitude forests. Various ancient Ayurveda classics, the authors have come across with some descriptions of a plant which matched strikingly with 'Arogyappacha' Sushruta, while dealing with the various divine drugs along with 'Some' also described one 'Varahi' - which he described as 'Kandha sambhava' -rhizomatous, 'Ekapatra' single leaves arising from a stem and 'Anjana samaprabha' - shining like he grey-black stone. Ethnopharmacological studies claimed that, the oral LD50 were found to be more than 3000mg/kg, with no signs of abnormalities or any mortality observed for 15 days period. Seeds of Trichopus zeylanicus showed a potent adaptogenic or antistress properties against a variety of stresses in both rats and mice. Treatment with Trichopus zeylanicus protected mice from tumour cell growth. Trichopus zeylanicus extract has been evaluated for its antihepatotoxic and cholerectic activities in rats. The effects of Trichopus zeylanicus on reactive oxygen species induced plasmid DNA (pBR322) cleavage were also investigated. Trichopus zeylanicus contains NADH, polyphenols and sulfhydryl compounds, which have the ability to scavenge reactive oxygen species.Keywords
Trichopus zeylanicus, Adaptogenic, Analgesic, Arogyapacha.- Ashtavarga:Eight Miraculous Herbs
Abstract Views :309 |
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Authors
V. V. Buchake
1,
R. S. Bachhav
2,
R. B. Rode
2,
S. S. Aher
2,
A. P. Muthal
2,
B. V. Dhokchawle
2,
R. B. Saudagar
2
Affiliations
1 KCT’s R. G. Sapkal College of Pharmacy, Anjaneri, Nashik – 422 212, IN
2 KCT’s R. G. Sapkal College of Pharmacy, Anjaneri, Nashik – 422 212 (MS), IN
1 KCT’s R. G. Sapkal College of Pharmacy, Anjaneri, Nashik – 422 212, IN
2 KCT’s R. G. Sapkal College of Pharmacy, Anjaneri, Nashik – 422 212 (MS), IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 4 (2010), Pagination: 260-263Abstract
The medicinal plants identified as Ashtavarg are Jeevak-Malaxis muscifera; Rishbhak-Malaxis acuminata; Meda- Polygonatum verticillatum; Mahameda- Polygonatm cirrifolium; Ridhi-Habenaria intermedia; Vridhi- Habenaria acuminata; Kakoli-Roscoea alpina and Kshirkakoli-Lilium polyphyllum. They were known to impart Jeevaniya - Vitality, Vayasthapan - revival of youthful conditions, body nourishment, and antioxidant effects. The great Ayurvedic sages Charak and Sushrut made a mention of 5 of Astavarg plants for use in Chyavanprash. Majority of these species are habituated in the Himalayan ranges. The north-western regions of Himalaya, Garhwal belt in Uttarpradesh, Kangra in Himalaya, Plateus of West Bengal, Kalpa district in Nepal, Kandy District and Hunnasgiriya in Sri Lanka, in the forests and grassy slopes of Gansu, Guangxi, Ningxia, Qinghai, Shaanxi, Sichuan, Xizang(as Chinese herbs) are the resident lands of these varied species. The hilly and remote forest areas of Auli, Joshimath, Tapovan, Badrinarayan, Hemkund, Ukhimath, Gangotri, Kedarnath, Renthal, Gangnani, Yamunotri, Rishikesh, Dhanaulti in Uttarakhand and Karsog, Jalpa, Kamarunag, Rewalsar, Rewanda, Lahaul-spiti, Hatloo, Thanedhar, Narkanda, Matiana, Shilaru in Himachal Pradesh are also rich heritage of these herbs. This expedition had fetched the most revitalizing species from the traditional Ayurvedic fraternity of therapy as a boon to mankind.Keywords
Orchids, Orchideaceae, Medicinal Plants, Ayurveda.- Review on Guideline on Elemental Impurities
Abstract Views :176 |
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Authors
Affiliations
1 Department of Quality Assurance Technique, R.G. Sapkal college of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
1 Department of Quality Assurance Technique, R.G. Sapkal college of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
Source
Asian Journal of Research in Chemistry, Vol 9, No 5 (2016), Pagination: 226-232Abstract
Abstract are related to the elemental impurities it included identification, structural elucidation and quantitative determination of impurities. It included According to ICH guidelines, Impurities associated with APIs are classified into the categories. In elemental impurities Four-step process to assess and control elemental impurities in the drug product. Identification of impurities is done by variety of Chromatographic and Spectroscopic techniques, either alone or in combination with other techniques. These impurities are control with strategy.Keywords
Elemental Impurities, Types of Impurities, Control Strategy.- Design, Synthesis and Anti Microbial, Anti-Inflammatory, Antitubercular Activities of Some 2,4,5-Trisubstituted Imidazole Derivatives
Abstract Views :201 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmaceutical Sciences, Bhagwant University, Ajmer, Rajashthan, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Nashik, M.S., IN
1 Department of Pharmaceutical Sciences, Bhagwant University, Ajmer, Rajashthan, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Nashik, M.S., IN
Source
Asian Journal of Pharmaceutical Research, Vol 3, No 4 (2013), Pagination: 159-165Abstract
A Novel Series of Some 2,4,5-trisubstituted imidazole derivatives were prepared with the aim to get better antibacterial activity, antifungal activity, antitubercular and anti-inflammatory activity. The structures of synthesized compounds were supported by means of IR, 1H NMR. Title compounds were evaluated for antibacterial activity, antifungal activity, antitubercular and anti-inflammatory activities. Among the synthesized compounds some compounds found to possess all these activities. The QSAR study for anti-inflammatory activity shows good results.Keywords
QSAR, Antibacterial, Antifungal, Anti-Inflammatory Activity.- Osmotically Controlled Drug Delivery System-A Novel Approach
Abstract Views :296 |
PDF Views:6
Authors
Affiliations
1 Department of Quality Assurance Technique R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
1 Department of Quality Assurance Technique R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 7, No 2 (2017), Pagination: 68-76Abstract
Osmotically controlled drug delivery systems (OCDDS) are most promising systems for controlled drug delivery. Osmotically controlled drug delivery systems utilize osmotic pressure for controlled delivery of active agents. Various patents are available for osmotic drug delivery system like Rose and Nelson pump, Higuchi Leeper pump, Higuchi Theeuwes pump, Elementary osmotic pump etc. Various techniques available for preparation of OCDDS include push pull osmotic pump, Osmotic bursting osmotic pump, Liquid OROS, Telescopic capsule for delayed release, OROS-CT (colon targeting), and Sandwiched osmotic tablet system. These systems can be used for systemic as well as targeted delivery of drugs. Drug delivery from these systems, to a large extent, is independent of physiological factors of GI tract. Release of drug from formulation is depends on various formulation factors such as solubility of drug, osmotic pressure generated in the system, size of the drug delivery orifice, nature and thickness of rate controlling membrane. The present review article mainly focus on the basic components of osmotically controlled drug delivery system, various factors governing drug release from these systems and types of osmotically controlled drug delivery systems. Osmotic drug delivery systems differ from diffusion based systems in that the delivery of the active agents is driven by an osmotic gradient rather than the concentration of drug in the device.Keywords
Osmotic Drug Delivery, Osmosis, Osmotic Gradient, Various Techniques for Osmotic Drug Delivery.- Nanosuspension:An Overview
Abstract Views :277 |
PDF Views:5
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 7, No 2 (2017), Pagination: 81-86Abstract
Nanosuspensions are important carriers to develop novel drug formulations. Nanosuspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages. Nanosuspension technology solved the problem of drugs which are poorly aqueous soluble and less bioavailability. Stability and bioavailability of the drugs can be improved by the Nanosuspension technology. Techniques such as media milling and high pressure homogenization have been used commercially for producing nanosuspensions. Nanosuspensions can be delivered by oral, parenteral, pulmonary and ocular routes.Nanosuspensions can also be used for targeted drug delivery when incorporated in the Ocular inserts and mucoadhesive hydrogels. Currently, efforts are being directed to extending their applications in site-specific drug delivery.Keywords
Nanosuspension, Solubility Enhancement, Particle Size, Surfactant, Colloidal Dispersion, Oral Bioavailability.- Review Article:Solubility Enhancement by Solid Dispersion
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Authors
Affiliations
1 Department of Pharmaceutics, R.G. Sapkal college of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal college of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, R.G. Sapkal college of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal college of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
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Asian Journal of Pharmacy and Technology, Vol 7, No 2 (2017), Pagination: 72-76Abstract
Enhancement of solubility, dissolution rate and bioavailability of drug is a very challenging task in drug development, nearly 40% of the new chemical entities currently being discovered are poorly water soluble drugs. The solubility behavior of the drugs remain one of the most challenging aspects in formulation development. This results in important products not reaching the market or not achieving their full potential. Solid dispersion is one of the techniques adopted for the formulation of such drugs and various methods are used for the preparation of solid dispersion. Solid dispersion is generally prepared with drug which is having poor aqueous solubility and hydrophilic carrier. This article review various methods and concept of solid dispersion, criteria for drug selection, advantage and disadvantage, characterization, and application.- In-Situ Nasal Gel-A Review
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Authors
Affiliations
1 Department of Quality Assurance Technique, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
1 Department of Quality Assurance Technique, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
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Asian Journal of Research in Pharmaceutical Sciences, Vol 7, No 1 (2017), Pagination: 23-32Abstract
Over the few decades, advances in the in-situ gel technologies have spurred development in many medical and biomedical applications including controlled drug delivery. Many Novel In-Situ gel based delivery matrices have been designed and fabricated to fulfill the ever increasing needs of the pharmaceutical and medical fields. In-Situ gel drug delivery systems are sol form before administration in the body, but once administered, undergo gelation in-situ, to form gel. The formation of gel depends on factors like temperature modulation, pH change, presence of ions from which drug get released in sustained and controlled manner. In-Situ gels exhibit the properties of linear polymer solutions outside the body (allowing easy injection) but gel In-Situ within the body, providing prolonged drug release profiles. Recently, it has been shown that many drugs have better bioavailability by nasal route than the oral route. This has been attributed to reach vasculature and highly permeable structure of nasal mucosa coupled with avoidance of Hepatic-first pass metabolism. Thus this review focuses on nasal drug delivery, various aspects of nasal anatomy and physiology, nasal absorption mechanism, and In-Situ gels evaluations.Keywords
Nasal In-Situ Gel, Absorption Enhancer, Nasal Formulation, Mucoadhesive Drug Delivery System.- Formulation and Evaluation of Stable Montelukast Sodium Sublingual Tablet by Using Lyophilization Technique
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
3 University Institute of Chemical Technology, NMU, Jalgoan, IN
1 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
3 University Institute of Chemical Technology, NMU, Jalgoan, IN
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Research Journal of Pharmaceutical Dosage Form and Technology, Vol 9, No 1 (2017), Pagination: 6-14Abstract
The aim of present work research work was formulation and evaluation of stable montelukast sodium sublingual tablet. Since The thermal stress testing study of Monte in solutions at 65°C showed that it is highly stable in NaOH solution, while it degrades rapidly in both acidic and H2O2 solutions. Hence lyophilization technology was adopted to increase the stability of montelukast sodium. Before lyophilization three trials were carried out to optimize the process parameters in which Trial 2 was considered as optimized process. The Lyophilization was carried out in nine different batches by varying the total cycle time, freezing and holding time, primary drying and secondary drying time by maintaining the quantities of all the active pharmaceutical ingredients constant and selection of cryoprotectant ratio. An optimized lyophilization cycle of 56 hours has been achieved. The optimized lyophilized product was subjected to Tablet compression. In this process the batch-9 formulation was considered as an optimized Formulation for compression with the process. All the in-vitro evaluation parameters complies the limits as per the specification. Stability studies were conducted and from the result it was concluded that the optimized formulation was found to be stable. Finally, it is concluded that the lyophilization is a suitable technique to increase the stability and bioavailability of Montelukast sodium.Keywords
Montelukast Sodium, Sodium Hydroxide, Hydroxypropyl Beta Cyclodextrin, Lyophilization, Freezing, Primary Drying, Secondary Drying.- Formulation, Development and Evaluation of Film-Forming Gel for Prolonged Dermal Delivery of Miconaole Nitrate
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, KCT’S R.G. Sapkal College of Pharmacy, Anjaneri, Nasik 422 213, Maharashtra, IN
2 Department of Quality Assurance and Techniques, KCT’s R.G. Sapkal College of Pharmacy, Anjaneri, Tal. Trimbakeshwar, Dist. Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutical Chemistry, KCT’S R.G. Sapkal College of Pharmacy, Anjaneri, Nasik 422 213, Maharashtra, IN
2 Department of Quality Assurance and Techniques, KCT’s R.G. Sapkal College of Pharmacy, Anjaneri, Tal. Trimbakeshwar, Dist. Nashik-422213, Maharashtra, IN
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Research Journal of Topical and Cosmetic Sciences, Vol 8, No 1 (2017), Pagination: 19-29Abstract
The localized treatment of diseases of body tissues requires that the pharmaceutical active be maintained at the site of treatment for an effective period of time. Sweat, clothing, movements and getting washed away easily on contact with water are some of the problems that have limited the effectiveness and residence time of conventional topical formulations for treatment of fungal infections of skin. This necessitates longer treatment duration. Hence, a composition that adheres to skin surface afflicted and provides localized delivery of an antifungal agent is needed. The present work aims at designing a dosage form of Miconazole nitrate referred to as a ‘film-forming gel’ which on application forms a thin, transparent film on skin surface. Eudragit RS PO and hydroxypropyl cellulose were used in combination to provide a matrix film that would permit the release of the antifungal agent for a prolonged time. The formulations were prepared using 32 full factorial design. They were tested for drying time, drug release, antifungal activity, skin irritation and stability studies. The gel was characterised for pH, viscosity, drug content, effective dosage volume and mechanical properties of the film formed after application; water vapour permeability were also tested. All the formulations showed results within acceptable range for various tests. The optimized formulation showed drug release of 99.76% and antifungal activity in terms of efficacy as 98.78%. Such a formulation can be claimed to decrease duration of therapy, will be more accepted by the patients and be a breakthrough in treating fungal infections of the skin.Keywords
Miconazole Nitrate; Fungal Skin Infections, Film-Forming Gel, Eudragit RS PO, Hydroxypropyl Cellulose.References
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- Nanoparticle- A Review
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Authors
Affiliations
1 Department of Quality Assurance Technique, R. G. Sapkal college of Pharmacy, Anjaneri Nashik, IN
2 Depatment of Pharmaceutical chemistry, R.G. Sapkal college of Pharmacy Anjaneri, Nashik, IN
1 Department of Quality Assurance Technique, R. G. Sapkal college of Pharmacy, Anjaneri Nashik, IN
2 Depatment of Pharmaceutical chemistry, R.G. Sapkal college of Pharmacy Anjaneri, Nashik, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 7, No 3 (2017), Pagination: 162-172Abstract
Nanotechnology refers to the creation and utilization of materials whose constituents exist at the nanoscale; and, by convention, be up to 100 nm in size. Nanotechnology explores electrical, optical, and magnetic activity as well as structural behaviour at the molecular and submolecular level. It has the potential to revolutionize a series of medical and biotechnology tools and procedures so that they are portable, cheaper, safer, and easier to administer. Nanoparticles are being used for diverse purposes, from medical treatments, using in various branches of industry production such as solar and oxide fuel batteries for energy storage, to wide incorporation into diverse materials of everyday use such as cosmetics or clothes, optical devices, catalytic, bactericidal, electronic, sensor technology, biological labelling and treatment of some cancers. Due to their exceptional properties including antibacterial activity, high resistance to oxidation and high thermal conductivity, nanoparticles have attracted considerable attention in recent years. Nanoparticles can be synthesized chemically or biologically. Metallic nanoparticles that have immense applications in industries are of different types, namely, Gold, Silver, Alloy, magnetic etc. This study aims to present an overview of nanoparticles, with special reference to their mechanism of biosynthesis and types.Keywords
Nanoparticles, Silver, Bactericidal, Thermal Conductivity, Optical Devices.References
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