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Rajak, Prem

Molecular Nexus between Insulin-Like Peptides and Downstream Kinases Regulate Glucose Homeostasis, Cell Survival and Growth in Drosophila

Abstract Views :294 | PDF Views:1

Authors

Prem Rajak ¹, Moutushi Mandi ², Anik Dutta ³, Sumedha Roy ²

Affiliations
1 Department of Zoology, A. B. N. Seal College, Cooch Behar, West Bengal, IN
2 Toxicology Research Laboratory, Department of Zoology, The University of Burdwan, Purba Bardhaman, West Bengal, IN
3 Department of Zoology, Darjeeling Government College, Darjeeling, West Bengal, IN

Source

Journal of Endocrinology and Reproduction, Vol 22, No 1 (2018), Pagination: 21-29

Abstract

Drosophila is a versatile model organism to study metabolic disorders, one such being diabetes mellitus. Eight insulin-like peptides (ILPs) have been identified in Drosophila. ILPs are produced from paired Insulin-producing cells present in brain ganglia. Another protein called adipokinetic hormone (AKH) is homologous to mammalian glucagon and is released from the corpora cardiaca. Synergistic action of ILP and AKH maintains sugar homeostasis in Drosophila. ILP binds with insulin receptors on the adipocytes and trigger autophosphorylation and dimerization. The activated receptors then initiate a downstream signaling by various modulators to phosphorylate Akt (protein kinase B, a serine-threonine-specific protein kinase). Akt, when activated, targets multiple signaling molecules including Target of Rapamycin (TOR) that participates in glucose metabolism, protein synthesis, cell proliferation, neuroendocrine signaling, and stress response. Akt also phosphorylates transcription factor FOXO that promotes cell survival by up-regulating TRAIL, a pro-apoptotic protein. High lipid accumulation in the fat body is linked with insulin resistance in Drosophila. Drosophila reared on high lipid diet shows up-regulation in protein kinase C (PKC). PKC is known to antagonize insulin signaling in fruit flies. A clear concept regarding the complex process of glucose homeostasis can be generated through further investigations. Since Drosophila has several advantages over vertebrate models, it can be used to identify additional modulators of insulin biology and metabolism.

Keywords

Akt, Drosophila, FOXO, Insulin-Like Peptides, TOR.

Full Text

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Protective Potential of Vitamin C and E against Organophosphate Toxicity: Current Status and Perspective

Abstract Views :145 | PDF Views:77

Authors

Prem Rajak ¹, Sumedha Roy ², Abhratanu Ganguly ¹, Moutushi Mandi ³, Anik Dutta ⁴, Saurabh Sarkar ⁵, Sayantani Nanda ¹, Salma Khatun ⁶, Siddhartha Ghanty ¹, Gopal Biswas ³

Affiliations
1 Department of Animal Science, Kazi Nazrul University, Asansol, West Bengal - 713340, IN
2 Cytogenetics Laboratory, Department of Zoology, The University of Burdwan, West Bengal - 713104, IN
3 Toxicology Research Unit, Department of Zoology, The University of Burdwan, Purba Bardhaman, West Bengal - 713104, IN
4 Post Graduate, Department of Zoology, Darjeeling Govt. College, Darjeeling, West Bengal - 734104, IN
5 Department of Zoology, Gushkara Mahavidyalaya, Gushkara, West Bengal - 713128, IN
6 Krishna Chandra College, Hetampur, Birbhum, West Bengal - 731124, IN

Source

Journal of Ecophysiology and Occupational Health, Vol 22, No 3 (2022), Pagination: 141-154

Abstract

Pesticides are an integral part of our daily life, used in agricultural fields, store rooms, residences and educational institutions to kill or repel pests. Several chemical subtypes of these compounds are available, of which organophosphate (OP) is major one. These are broad spectrum pesticides used to kill insect pests. OPs are useful but indeed they are most frequent reasons of pesticide poisoning across the globe. OP inhibits acetylcholinesterase activities that results in continuous hyper-excitable state of nicotinic and muscarinic receptors at neuromuscular junctions. Intentional or unintentional exposure to OPs causes abdominal pain, diarrhea, vomiting, muscular weakness, dementia, Central Nervous System (CNS) dysfunction and even death. Besides acetylcholinesterase inhibition, OPs are also known to trigger ROS generation within the cellular machinery which results in Oxidative Stress (OS). Free Radicals (FRs) are neutralized by antioxidant-defense system of the body. Vitamin C and vitamin E are the major exogenous antioxidants that scavenge a large amount of free radicals by donating their own electrons to FRs. This phenomenon reduces ROS and hence, OS is prevented. Therefore, vitamin C and E can be considered for daily dietary intake which might be providing prophylactic advantage against OP induced OS and pathophysiology in human beings.

Keywords

Ascorbic Acid, Organophosphates, Oxidative Stress, ROS, Tocopherol

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Fluoride Contamination, Toxicity and its Potential Therapeutic Agents

Abstract Views :370 | PDF Views:0

Authors

Prem Rajak ¹, Sumedha Roy ², Salma Khatun ³, Moutushi Mandi ⁴, Abhratanu Ganguly ¹, Kanchana Das ⁴, Anik Dutta ⁵, Sayantani Nanda ¹, Siddhartha Ghanty ¹, Gopal Biswas ⁴

Affiliations
1 Department of Animal Science, Kazi Nazrul University, Asansol – 713340, West Bengal, IN
2 Cytogenetics Laboratory, Department of Zoology, The University of Burdwan, Purba Bardhaman – 713104, West Bengal, IN
3 Department of Zoology, Krishna Chandra College, Hetampur – 731124, West Bengal, IN
4 Toxicology Research Unit, Department of Zoology, The University of Burdwan, Purba Bardhaman – 713104, West Bengal, IN
5 Post Graduate Department of Zoology, Darjeeling Government College, Darjeeling –734104, West Bengal, IN

Source

Toxicology International (Formerly Indian Journal of Toxicology), Vol 29, No 4 (2022), Pagination: 553-565

Abstract

Fluoride is the thirteenth most abundant element in the earth’s crust. It is highly electronegative and distributed ubiquitously in nature. During weathering of rocks and soil, fluoride can leach out and dissolve in the groundwater. Both plants and animals are exposed to several compounds of fluoride through contaminated soil and water. Fluoride contamination in groundwater is a major global concern as groundwater is frequently used for drinking in various parts of the world, especially in developing countries. Fluoride compounds have been reported to impose acute and chronic health hazards. Millions of global populations are suffering from dental and skeletal fluorosis due to high fluoride intake through drinking water. In green vegetation, fluoride accumulation causes necrosis in the tip and marginal portions of leaves. Diverse detrimental effects of fluoride on health have insisted researchers globally to identify compounds having protective potential against fluoride toxicity. Several plant extracts, vitamins, polyphenols, melatonin, hypophyseal proteins, and lycopene have been demonstrated to enhance the antioxidant status and subvert fluoride-induced health hazards in model organisms. However, more studies are required to forward conclusive opinions in terms of the real-life efficacy of these antioxidants against fluoride toxicity.

Keywords

Selected:Fluoride, Fluorosis, Lycopene, Melatonin, Oxidative Stress.Remove Fluoride, Fluorosis, Lycopene, Melatonin, Oxidative Stress.

Full Text

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Dutta M, Rajak P, Khatun S, Roy S. Toxicity assessment of sodium fluoride in Drosophila melanogaster after chronic sub-lethal exposure. Chemosphere. 2017; 166:255-266. https://doi.org/10.1016/j.chemosphere.2016.09.112 PMid:27700992

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Mailloux RJ, Harper ME. Uncoupling proteins and the control of mitochondrial reactive oxygen species production. Free Radic Biol Med. 2011; 51:1106-1115 https://doi.org/10.1016/j.freeradbiomed.2011.06.022 PMid:21762777

Rajak P, Roy S. Heat shock proteins and pesticide stress. In Regulation of Heat Shock Protein Responses. Springer, Cham; 2018. p. 27-40. https://doi.org/10.1007/978-3-319-74715-6_2

Kim I, Xu W, Reed JC. Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Discov. 2009; 7:1013-1030. https://doi.org/10.1038/nrd2755 PMid:19043451

Rajak P, Ganguly A, Sarkar S, Mandi M, Dutta M, Podder S, Khatun S, Roy S. Immunotoxic role of organophosphates: An unseen risk escalating SARS-CoV-2 pathogenicity. Food Chem Toxicol. 2021; 149:112007. https://doi.org/10.1016/j.fct.2021.112007 PMid:33493637 PMCid:PMC7825955

Jiang C, Zhang S, Liu H, Zeng Q, Xia, T. The role of the IRE1 pathway in PBDE- 47-induced toxicity in human neuroblastoma SH-SY5Y cells in vitro. Toxicol Lett. 2012; 211: 325-333. https://doi.org/10.1016/j.toxlet.2012.04.009 PMid:22543052

Rajak P, Dutta M, Khatun S, Mandi M, Roy S. Exploring hazards of acute exposure of Acephate in Drosophila melanogaster and search for l-ascorbic acid mediated defense in it. J Hazard Mater. 2017; 321:690-702. https://doi.org/10.1016/j.jhazmat.2016.09.067 PMid:27701059

Mandi M, Khatun S, Rajak P, Mazumdar A, Roy S. Potential risk of organophosphate exposure in male reproductive system of a non-target insect model Drosophila melanogaster. Environ Toxicol Pharmacol. 2020; 74:103308. https://doi.org/10.1016/j.etap.2019.103308 PMid:31816565

Ghanty S, Mandi M, Ganguly A, Das K, Dutta A, Nanda S, Biswas G, Rajak P. Lung surfactant proteins as potential targets of prallethrin: An in silico approach. Toxicol. Environ Health Sci. 2022; 14(1):89-100. https://doi.org/10.1007/s13530-021-00119-0 PMCid:PMC8788395

Rajak P, Roy S, Pal AK, Paramanik M, Dutta M, Podder S, Sarkar S, Ganguly A, Mandi M, Dutta A, Das K, Ghanty S, Khatun S. In silico study reveals binding potential of rotenone at multiple sites of pulmonary surfactant proteins: A matter of concern. Curr Res Toxicol. 2021; 4:2:411-423. https://doi.org/10.1016/j.crtox.2021.11.003 PMid:34917955 PMCid:PMC8666459

Dutta M, Rajak P, Roy S, Determination of chronic median lethal concentration of sodium fluoride in Drosophila melanogaster and exploring effect of sub-lethal concentrations on differential hemocyte count. Proc. Zool Soc. 2019; 72:111-117. https://doi.org/10.1007/s12595-017-0235-x

Sarkar S, Rajak P, Roy S. Toxicological evaluation of a new lepidopteran insecticide, flubendiamide, in non-target Drosophila melanogaster Meigen (Diptera: Drosophilidae). IJT. 2018; 12(3): 45-50. https://doi. org/10.32598/IJT.12.3.477.1

Rajak P, Roy S. Heat Shock Proteins and Pesticide Stress. In: Asea, A., Kaur, P. (eds) Regulation of Heat Shock Protein Responses. Heat Shock Proteins. Springer, Cham; 2018. p. 13. https://doi.org/10.1007/978-3-319- 74715-6_2

Rajak P, Sahana S, Roy S. Acephate-induced shortening of developmental duration and early adult emergence in a nontarget insect Drosophila melanogaster. Toxicol Environ Chem. 2013; 95:1369-1379. https://doi.org/10.1080/02772248.2014.880608

Rajak P, Dutta M, Roy S. Altered differential hemocyte count in 3rd instar larvae of Drosophila melanogaster as a response to chronic exposure of Acephate. Interdiscip. Toxicol. 2015; 8:84-88. https://doi.org/10.1515/intox-2015-0013 PMid:27486365 PMCid:PMC4961902

Rajak P, Roy S, Podder S, Dutta M, Sarkar S, Ganguly A, Mandi M, Dutta A, Nanda S, Khatun S. Synergistic action of organophosphates and COVID-19 on inflammation, oxidative stress, and renin-angiotensin system can amplify the risk of cardiovascular maladies. Toxicol Appl Pharmacol. 2022; 456:116267. https://doi.org/10.1016/j. taap.2022.116267 PMid:36240863 PMCid:PMC9554205

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Rajak, Prem

Molecular Nexus between Insulin-Like Peptides and Downstream Kinases Regulate Glucose Homeostasis, Cell Survival and Growth in Drosophila

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Protective Potential of Vitamin C and E against Organophosphate Toxicity: Current Status and Perspective

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Fluoride Contamination, Toxicity and its Potential Therapeutic Agents

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