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Sudheer, Preethi
- Self Emulsifying Drug Delivery System - An Innovative Approch for Enhacement of Solubility and Therapeutic Potential
Abstract Views :194 |
PDF Views:82
Authors
Affiliations
1 Department of Pharmaceutics, Krupanidhi College of Pharmacy, Chikka Bellandur, Carmelaram Post, Varthur Hobli, Bangalore-560035, IN
1 Department of Pharmaceutics, Krupanidhi College of Pharmacy, Chikka Bellandur, Carmelaram Post, Varthur Hobli, Bangalore-560035, IN
Source
Journal of Pharmaceutical Research, Vol 15, No 4 (2016), Pagination: 153-161Abstract
Purpose: As the development of modern drug discovery techniques, there has been increase in the number of pharmaceutical compounds that are poorly water soluble. These lipophilic compounds possess low dissolution rate and therefore low bioavailability. The Formulation scientists should adopt various strategies to enhance their absorption. This paper is an insight for improving the solubility of poorly water soluble compounds.
Approach: Lipidic formulations are found to be a promising approach to combat the solubility challenges. Self Micro Emulsifying Drug Delivery Systems (SMEDDS) are gaining more attention for improving the solubility of the lipophilic drugs.
Findings: SMEDDS are isotropic mixtures of oil, surfactant and co surfactant and are vital tool in solving low bioavailability problems of poorly soluble drugs. Lipophilic drugs can be dissolved in these systems, enabling them to be administered per orally. When this is released into the lumen it results in w/o microemulsion with the aid of G.I fluid.
Conclusion: This present review describes various formulation components, mechanism of emulsification, biopharm aspects, characterization methods and application of SMEDDS.
Keywords
Surfactants, Solubility, SMEDDS, Microemulsion.Full Text
References
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- Pattewar S, Kasture S, Pande V, Sharma S. Self microemulsifying drug delivery system: A lipid based drug delivery system. Int J Pharm Sci Res 2016; 7(2):443-452.
- Saxena S, Chaturvedi S, Agarwal V. Lipid excepients in self emulsifying drug delivery system. Research gate. Available online at: https://www.researchgate.net/publication/2 58424092.
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- Akula S, Gurram AK, Devireddy SR. Self microemulsifying drug delivery system: An attractive strategy for enhanced therapeutic profile. International scholarly research notices. 2014. Available online at: http://dx.doi.org/10.1155/2014/964051.
- Bipin kumar DJ, Dr. Patel MR. Self microemulsifying drug delivery system: A Review. World journal of pharmacy and pharmaceutical sciences 2016; 5(4):2215-2232.
- Mehta K, Borade G, Rasve G, bender A. Self-emulsifying drug delivery system: Formulation and evaluation. Int J Pharm Bio Sci. 2011; 2(4):398-412.
- Singh PK, Iqubal MK, Shukla VK, Shuaib M. Microemulsion: Current trends in novel drug deliverysystem. Journal of pharmaceutical, chemical and biological sciences. 2014; 1(1): 39-51.
- Muzaffar F, Singh UK, Chauhan L. Review on microemulsion as futuristic drug delivery. Int J Pharm Pharm Sci. 2013; 5(3):39-53.
- Gupta S, Kesarla R, Omeri A. Formulation strategies to improve the bioavailability of poorly absorbed drugs with special emphasis on self emulsifying system. ISRN Pharmaceutics. 2013. Available online at: http://dx.doi.org/10.1155/2013/848043.
- Deokate UA, Shinde N, Bhingare U. Novel approaches for development and characterization of SMEDDS: Review. Int J Curr Pharm Res. 2013; 5(4):5-12.
- Yeole SE, Pimple SS, Gale GS, Gonarkar AG, Nigde AT, Randhave AK, Chaudhari PD. A Review- Self microemulsifying drug delivery systems. Indo American journal of pharmaceutical research. 2013; 3(4) 3031-43.
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- Formulation and Evaluation of Lipid Microspheres of Ketoprofen
Abstract Views :208 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, East Point College of Pharmacy, Bidarahalli, Virgo Nagar Post, Bangalore, 560049, IN
2 East Point College of Pharmacy, Bidarahalli, Virgo Nagar Post, Bangalore, 560049, IN
1 Department of Pharmaceutics, East Point College of Pharmacy, Bidarahalli, Virgo Nagar Post, Bangalore, 560049, IN
2 East Point College of Pharmacy, Bidarahalli, Virgo Nagar Post, Bangalore, 560049, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 5 (2010), Pagination: 340-343Abstract
Lipid microspheres of ketoprofen was prepared by emulsification method using waxes such as bees wax, carnauba wax and cetosteryl alcohol. These microspheres were evaluated for in-vitro dissolution studies, thin layer chromatography, scanning electron microscopy and particle size analysis. Lipid microspheres were studied for diffusion characteristics using cellophane membrane and permeation characteristics through excised rat abdominal skin. Lipid microspheres were found to increase the rate of permeation of poorly absorbable ketoprofen, so they may be used as a potential carrier in increasing the rate of absorption in case of topical delivery of drugs.Keywords
Lipid Microspheres, Ketoprofen, Emulsification, Diffusion.
- Minitablet: A Novel Approach for Oral Extended Release
Abstract Views :187 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmaceutics, East Point College of pharmacy, Bidsrshalli, Virgo Nagar Post, Bangalore-560049, IN
1 Department of Pharmaceutics, East Point College of pharmacy, Bidsrshalli, Virgo Nagar Post, Bangalore-560049, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 1, No 3 (2009), Pagination: 263-268Abstract
The present study is carried out to compare matrix tablets and mini tablets of Diltiazem hydrochloride. Matrix tablets and mini-matrix tablets containing Diltiazem hydrochloride have been prepared by wet granulation technique. The hydrophilic matrix was formed with chitosan together with the additives. Preparation, the swelling and erosion behavior, in-vitro release profiles and release kinetics and mechanism of release are discussed. Comparison of all the parameters of matrix and mini matrix tablets is discussed. The result shows that mini matrix tablets shows more extended release profile in comparison with the matrix tablets under similar conditions.Keywords
Matrix Tablets, Chitosan, Minitablets, Diltiazem Hydrochloride.- A Review:Solid Dispersion, a Technique of Solubility Enhancement
Abstract Views :329 |
PDF Views:101
Authors
Affiliations
1 Krupanidhi College of Pharmacy, Chikkabellandur Village, Carmelaram Post, Varthur Hobli, Bangalore - 560035, IN
1 Krupanidhi College of Pharmacy, Chikkabellandur Village, Carmelaram Post, Varthur Hobli, Bangalore - 560035, IN
Source
Journal of Pharmaceutical Research, Vol 16, No 1 (2017), Pagination: 25-31Abstract
Purpose: The aim of the study was to explore the necessity, advantages and different techniques of solid dispersion for enhancing solubility of poorly soluble drugs.
Approach: Different types of solid dispersion have been explained briefly along with the various techniques of solid dispersion in detail.
Findings: Solid dispersions of poorly soluble drugs have been found to give positive results in enhancing its solubility and dissolution characters.
Conclusion: Solid dispersion techniques improve solubility and bioavailability of poorly soluble drugs. Solid dispersions can be incorporated into various dosage forms with wide range of applicability.
Keywords
Solid Dispersion Techniques, Solubility, Advantages, Disadvantages, Carriers.Full Text
References
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- Solid Lipid Nanoparticles- An Innovative Approach for Improving the Solubility and Bioavailability
Abstract Views :174 |
PDF Views:68
Authors
Affiliations
1 Department of Pharmaceutics, Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelaram Post, Varthur Hobli, Bangalore - 560035, KA, IN
1 Department of Pharmaceutics, Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelaram Post, Varthur Hobli, Bangalore - 560035, KA, IN
Source
Journal of Pharmaceutical Research, Vol 16, No 2 (2017), Pagination: 148-153Abstract
Purpose: The purpose of this study is to give a general review on solid lipid nanoparticles (SLNs) as a novel drug carrier for improving the solubility and bioavailability of drugs.
Approach: Among the various colloidal drug carriers, SLNs have been emerged as next generation drug delivery system for incorporating lipophilic drugs. They are relatively nontoxic and nonirritant. The review insight on the various methods of preparation, characterization and also the application of SLNs for improving the solubility and bioavailability is explained here.
Findings: SLNs is used as a novel carrier for improving the solubility of poorly soluble drugs which may results in enhanced bioavailability and stability of drug can also be improved by incorporating drug in the form of solid lipid nanoparticles.
Conclusion: This review presents an overview of SLNs which includes SLN and its properties, excipients, techniques used in preparation of SLNs, characterization, and their applications.
Keywords
Bioavailability, Solubility, Lipophilic, Stability, Advantages, Disadvantages.Full Text
References
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- Mucoadhesive Polymers:A Review
Abstract Views :416 |
PDF Views:85
Authors
Affiliations
1 Department of Pharmaceutics, 12/1, Krupanidhi College of Pharmacy, Chikkabellandur, Carmelaram Post, Varthur (H), Bangalore-560035, IN
1 Department of Pharmaceutics, 12/1, Krupanidhi College of Pharmacy, Chikkabellandur, Carmelaram Post, Varthur (H), Bangalore-560035, IN
Source
Journal of Pharmaceutical Research, Vol 17, No 1 (2018), Pagination: 47-55Abstract
Purpose: Aim of the study is to explore the concept of mucoadhesion, theories and the various polymers used in mucoadhesive drug delivery. Approach: An extensive review is carried out on mechanism of mucoadhesion, theories, polymers used in mucoadhesive dosage forms and its applications. Finding: Mucoadhesive polymers increases the residence time, prolongs the absorption, enhances solubility and dissolution characteristics of poorly soluble drugs. Conclusion: Mucoadhesive polymers was found to be a novel drug carrier used in buccal, nasal, vaginal, ocular, rectal drug delivery which improves bioavailability of poorly soluble drugs.Keywords
Mucoadhesive Polymer, Mucoadhesion, Bioavailability.Full Text
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