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Co-Authors
- R. Narayana Charyulu
- D. S. Sandeep
- Abhishiktha Alva
- Divya Rao
- Jobin Jose
- K. C. Bahrath Raj
- P. B. Ashwini
- Sharmila Banerjee
- Sandip Basu
- Akshay D. Baheti
- Suyash Kulkarni
- Venkatesh Rangarajan
- Vedang Murthy
- Anuj Kumar
- Sarbani G. Laskar
- J. P. Agarwal
- Sudeep Gupta
- R. A. Badwe
- Pankaj Kumar
- Abhishek Kumar
- Jean Sandra Pinto
- Sachin A. Kumbar
- Nanditha Bhat
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Nayak, Prashant
- Formulation and Evaluation Ungual Drug Delivery System of Antifungal Agent for Nail Disorders
Abstract Views :155 |
PDF Views:1
Authors
R. Narayana Charyulu
1,
D. S. Sandeep
1,
Abhishiktha Alva
1,
Divya Rao
1,
Prashant Nayak
1,
Jobin Jose
1,
K. C. Bahrath Raj
2
Affiliations
1 Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka, IN
2 Department of Pharmacology, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka, IN
1 Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka, IN
2 Department of Pharmacology, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 3 (2017), Pagination: 869-872Abstract
Fungal infections affecting nails are commonly seen around the world. The effectiveness of topical therapies is limited by minimal drug permeability through the nail plate. Nail permeability is however quite low and limits topical therapy to early/mild disease states such as onychomycosis (fungal infections of the nail). The current research aims at ungual drug delivery system as an effective treatment in nail infections. The formulations of nail lacquer were made with Amorolfine as antifungal agent using different concentration of polymer Eudragit RL 100 (ERL 100). Among 6 formulations, formulation F5 and F6 showed very good physical characteristics like viscosity, water resistance, stability, drying time, smoothness as compared to other formulations. The zone of inhibition of antifungal activity showed desired results (F5 and F6).Keywords
Nail Lacquer, Polymer, Ungual Drug Delivary, Viscosity.- Oral Dispersible Films, Novel Technology for the Delivery of Drugs
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Authors
Affiliations
1 Department of Pharmaceutics, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE Deemed to be University, Paneer, Deralakatte, Mangalore – 575018, IN
1 Department of Pharmaceutics, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE Deemed to be University, Paneer, Deralakatte, Mangalore – 575018, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 1 (2019), Pagination: 425-428Abstract
Various dosage forms have been introduced in the recent days in the field of pharmaceutical technology. Transdermal patch is a technique from which a new drug delivery system that is oral dispersible film was developed. Oral dispersible films when they placed on mouth or oral cavity, they disintegrate or dissolve within a minute. Even though in a solid dosage form it doesn’t require chewing or drinking of water, which enhances the patient compliance. There are number of ingredients are used to formulate oral dispersible patches, like active pharmaceutical ingredients, polymers, flavouring agents, colouring agents etc, in which we can regard polymer as important ingredient which helps to form the film. Usually hydrophobic polymer are used for oral dissolving films which breaks down on the tongue or buccal cavity and then drug will go to systemic circulation. Fast disintegrating property, good mechanical property like mouth dissolving property of film can be achieved by water soluble polymer. Moreover in oral dispersible films, accurate and effective dosing can be accomplished in a safe manner.Keywords
Oral Dispersible Films, Hydrophilic Polymers, Plasticizers, Solvent Casting.References
- Irfan M, Khan A. orally disintegrating film: A modern Expansion in drug delivery system. 2016; 24(5):537-546.
- Scarpa M, Stegemann S, Hsiao WK. Orodispersilble films: Towards drugs delivery in special population. International Jornal of Pharmaceutics. 2017;523(1):327-335.
- Chandra A, Pathak K, Sharma V. Fast dissolving oral films:An innovative drug delivery system and dosage form. International Journal of chemistry and technological research. 2010;2(1):576-583.
- Vijendar C, Sudheer Kumar D, Krishnaveni J. Formulation and evaluation of fast dissolving oral films of diazepam. Journal of pharmacovigilance. 2016;4(3):2329-6887.
- Hoffmann M E, Beitenbach A, Breitkreutz J. Advances in orodispersable films for drug delivery. Expert opinion in drug deliv. 2011;8(3):299-316
- Jose J, Netto G. Role of solid lipid nanoparticles as photoprotective agents in cosmetics. journal Cosmetic Dermatology. 2018; 00:1–7. https://doi.org/10.1111/jocd.12504.
- Bhyan B, Jangra S, Kaur M, Singh H. Orally fast dissolving films: Innovations in formulation and technology. International Journal of Pharmaceutical science review and research. 2011;9(2): 50-57.
- Mashru RC, Sutariya VB, Sankalia MG, Parikh PP. Development and evaluation of fast-dissolving film of salbutamol sulphate. Drug Dev Ind Pharm. 2005;35:25–34
- Joshua JM, Hari R, Jyothish KF et al. Fast dissoliving oral thin films an effective dosage form for quick release. International Journal of Pharmaceutical Sciences Review and Research. 2016;38(1):282-289
- Pathare YS, Hastak VS, Bajaj AN. Polymers used for fast disintegrating oral films. International Journal of pharmaceutics science and research. 2013;21(1):169-178.
- Raghuraman S, Velrajan G, Ravi R, Jeyabalan B, Benito Johnson D, Sankar V. Design and evaluation of propranolol hydrochloride buccal films. Indian Journal of Pharmaceutical Sciences. 2002;64:32–6.
- Kumar GV, Krishna RV, William GJ, Konde A. Formulation and evaluation of buccal films of salbutamol sulphate. Indian Journal of Pharmaceutical Sciences. 2005;67:160–4.
- Sharma D, Kauri D, Varma S et al. Fast dissolving oral films technology:a recent trend for an innovative oral drug delivery system. International Journal of Drug Delivery. 2015;7(2):60-75.
- Mashru RC, Sutariya VB, Sankalia MG, Parikh PP. Development and evaluation of fast dissolving film of salbutamol sulphate. Drug Develoment and Industrial Pharmacy. 2005;31:25–34.
- Jose J, Charyulu RN. Prolonged drug delivery system of an antifungal drug by association with polyamidoamine dendrimers. International Journal of Pharmaceutical Investigation.2016; 6(2):123–127.
- Deepthi S, Jose, J. Novel hydrogel-based ocular drug delivery system for the treatment of conjunctivitis. International Ophthalmology. 2018; https://doi.org/10.1007/s10792-018-0955-6.
- Ali MS, Vijendar C, Kumar SD, Krishnaveni J. Formulation and evaluation of fast dissolving oral films of diazepam. Journal of pharmacovigilance. 2016;4:210.
- Radiation and radioisotopes for human healthcare applications
Abstract Views :172 |
PDF Views:75
Authors
Sharmila Banerjee
1,
Sandip Basu
2,
Akshay D. Baheti
3,
Suyash Kulkarni
3,
Venkatesh Rangarajan
3,
Prashant Nayak
3,
Vedang Murthy
3,
Anuj Kumar
3,
Sarbani G. Laskar
3,
J. P. Agarwal
3,
Sudeep Gupta
1,
R. A. Badwe
4
Affiliations
1 Advanced Centre for Treatment Research & Education in Cancer, Kharghar, Tata Memorial Centre, Navi Mumbai 410 210, India; Homi Bhabha National Institute, DAE, Anushaktinagar, Mumbai 400 094, India
2 Radiation Medicine Centre, BARC, Parel, Mumbai 400 012, India; Homi Bhabha National Institute, DAE, Anushaktinagar, Mumbai 400 094, India
3 Tata Memorial Hospital, Parel, Mumbai 400 012, India; Homi Bhabha National Institute, DAE, Anushaktinagar, Mumbai 400 094, India
4 Tata Memorial Centre, Parel, Mumbai 400 012, India; Homi Bhabha National Institute, DAE, Anushaktinagar, Mumbai 400 094, India
1 Advanced Centre for Treatment Research & Education in Cancer, Kharghar, Tata Memorial Centre, Navi Mumbai 410 210, India; Homi Bhabha National Institute, DAE, Anushaktinagar, Mumbai 400 094, India
2 Radiation Medicine Centre, BARC, Parel, Mumbai 400 012, India; Homi Bhabha National Institute, DAE, Anushaktinagar, Mumbai 400 094, India
3 Tata Memorial Hospital, Parel, Mumbai 400 012, India; Homi Bhabha National Institute, DAE, Anushaktinagar, Mumbai 400 094, India
4 Tata Memorial Centre, Parel, Mumbai 400 012, India; Homi Bhabha National Institute, DAE, Anushaktinagar, Mumbai 400 094, India
Source
Current Science, Vol 123, No 3 (2022), Pagination: 388-395Abstract
The use of radiation and radioisotopes in human healthcare has been one of the early developments in the non-power applications of nuclear science. The field encompasses different facets of the use of radiation in the diagnosis and therapy of a wide variety of diseases, particularly cancer, the formidable challenge of the present century. There has been a significant advancement in different areas such as diagnostic radiology, diagnostic nuclear medicine, therapeutic radiation and therapeutic nuclear medicine, including theranostic applications in personalized medicine. The R&D efforts of the Department of Atomic Energy towards ensuring indigenous availability of established radiopharmaceuticals and treatment modalities as well as to develop emerging ones for state-of-the-art radiation-related services have been significant over the years. This article presents the current status, recent developments, clinical translation of developed products and prospects related to the use of radioisotopes and radiation in the two premiere research institutions of DAE, viz. BARC and TMC.References
- Hricak, H. et al., Managing radiation use in medical imaging: a multifaceted challenge. Radiology, 2011, 258, 889–905.
- Kumar, M., Shanavas, M., Sidappa, A. and Kiran, M., Cone beam computed tomography – know its secrets. J. Int. Oral Health, 2015, 7, 64–68.
- Lorente-Ramos, R., Azpeitia-Armán, J., Muñoz-Hernández, A., García-Gómez, J. M., Díez-Martínez, P. and Grande-Bárez, M., Dual-energy X-ray absorptiometry in the diagnosis of osteoporosis: a practical guide. Am. J. Roentgenol., 2011, 196, 897–904.
- Joe, B. N. and Sickles, E. A., The evolution of breast imaging: past to present. Radiology, 2014, 273, S23–S44.
- Liguori, C. et al., Emerging clinical applications of computed tomography. Med. Devices (Auckl.), 2015, 8, 265–278; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467659/.
- Okamoto, K., Ito, J., Sakao, K. and Yoshimura, S., The principle of digital subtraction angiography and radiological protection. Interv. Neuroradiol., 2000, 6, 25–31.
- Blahd, W. H., Ben Cassen and the development of the rectilinear scanner. Semin. Nucl. Med., 1996, 26, 165–170.
- Stefanović, L., The beginnings and development of diagnostic imaging in nuclear medicine. Med. Pregl., 2001, 54, 289–296.
- Eckelman, W. C., Radiolabeling with technetium-99m to study high-capacity and low-capacity biochemical systems. Eur. J. Nucl. Med., 1995, 22, 249–263.
- Wrenn, F. R., Good, M. L. and Handler, P., The use of positron-emitting radioisotopes for the localization of brain tumors. Science, 1951, 113, 525–527.
- Phelps, M. E., Hoffman, E. J., Mullani, N. A. and Ter-Pogossian, M. M., Application of annihilation coincidence detection to transaxial reconstruction tomography. J. Nucl. Med., 1975, 16, 210–224.
- Kuhl, D. E., Edwards, R. Q., Ricci, A. R., Yacob, R. J., Mich, T. J. and Alavi, A., The Mark IV system for radionuclide computed tomography of the brain. Radiology, 1976, 121, 405–413.
- Kallini, J. R., Gabr, A., Salem, R. and Lewandowski, R. J., Transarterial radioembolization with yttrium-90 for the treatment of hepatocellular carcinoma. Adv. Ther., 2016, 33, 699–714.
- Thakral, P., Sen, I., Das, S. S., Manda, D., Virupakshappa, C. B. and Malik, D., Dosimetric analyses of intra-arterial versus standard intravenous administration of 177Lu-DOTATATE in patients of well differentiated neuroendocrine tumor with liver-dominant metastatic disease. Br. J. Radiol., 2021, 94, 20210403.
- Ebbers, S. C., Braat, A. J. A. T., Moelker, A., Stokkel, M. P. M., Lam, M. G. E. H. and Barentsz, M. W., Intra-arterial versus standard intravenous administration of lutetium-177-DOTA-octreotate in patients with NET liver metastases: study protocol for a multicenter, randomized controlled trial (LUTIA trial). Trials, 2020, 21, 141.
- Al-Sarraf, M. et al., Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099. J. Clin. Oncol., 1998, 16, 1310–1317.
- Nigro, N. D., Seydel, H. G., Considine, B., Vaitkevicius, V. K., Leichman, L. and Kinzie, J. J., Combined preoperative radiation and chemotherapy for squamous cell carcinoma of the anal canal. Cancer, 1983, 51, 1826–1829.
- Gupta, S. et al., Neoadjuvant chemotherapy followed by radical surgery versus concomitant chemotherapy and radiotherapy in patients with stage IB2, IIA, or IIB squamous cervical cancer: a randomized controlled trial. J. Clin. Oncol., 2018, 36, 1548–1555.
- Wolf, G. T. et al., Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N. Engl. J. Med., 1991, 324, 1685–1690.
- James, N. D. et al., Radiotherapy with or without chemotherapy in muscle-invasive bladder cancer. N. Engl. J. Med., 2012, 366, 1477–1488.
- Palma, D. A. et al., Stereotactic ablative radiotherapy versus standard of care palliative treatment in patients with oligometastatic cancers (SABR-COMET): a randomised, phase 2, open-label trial. Lancet, 2019, 393, 2051–2058.
- Pillai, M. R. A., Chakraborty, S., Das, T., Venkatesh, M. and Ramamoorthy, N., Production logistics of 177Lu for radionuclide therapy. Appl. Radiat. Isot., 2003, 59, 109–118.
- Banerjee, S., Pillai, M. R. A. and Knapp, F. F., Lutetium-177 therapeutic radiopharmaceuticals: linking chemistry, radiochemistry, and practical applications. Chem. Rev., 2015, 115, 2934–2974.
- Das, T. and Banerjee, S., Theranostic applications of lutetieum-177 in radionuclide therapy. Curr. Radiopharm., 2016, 9, 94–101.
- Mitra, A. et al., On the separation of yttrium-90 from high-level liquid waste: purification to clinical-grade radiochemical precursor, clinical translation in formulation of 90Y-DOTATATE patient dose. Cancer Biother. Radiopharm., 2021, 36, 143–159.
- Avram, A. M., Zukotynski, K., Nadel, H. R. and Giovanella, L., Management of differentiated thyroid cancer: the standard of care. J. Nucl. Med., 2022, 63, 189–195.
- Pryma, D. A. et al., Efficacy and safety of high-specific-activity 131I-MIBG therapy in patients with advanced pheochromocytoma or paraganglioma. J. Nucl. Med., 2019, 60, 623–630.
- Ahmadzadehfar, H., Rahbar, K., Essler, M. and Biersack, H. J., PSMA-based theranostics: a step-by-step practical approach to diagnosis and therapy for mCRPC patients. Semin. Nucl. Med., 2020, 50, 98–109.
- Basu, S. et al., One decade of ‘bench-to-bedside’ peptide receptor radionuclide therapy with indigenous [177Lu]Lu-DOTATATE obtained through ‘direct’ neutron activation route: lessons learnt including practice evolution in an Indian setting. Am. J. Nucl. Med. Mol. Imag., 2020, 10, 178–211.
- Suman, S. et al., Therapeutic efficacy, prognostic variables and clinical outcome of 177Lu-PSMA-617 PRLT in progressive mCRPC following multiple lines of treatment: prognostic implications of high FDG uptake on dual tracer PET-CT vis-à-vis Gleason score in such cohort. Br. J. Radiol., 2019, 92, 20190380.
- The Electromagnetic Spectrum: Non-Ionizing Radiation; https://www.cdc.gov/nceh/radiation/nonionizing_radiation.html (last accessed on 10 July 2022).
- Hall, E. J. and Giaccia, A. J., Textbook of Radiobiology, 2019, 8th edn.
- Hamada, N. and Fujimichi, Y., Classification of radiation effects for dose limitation purposes: history, current situation and future prospects. J. Radiat. Res., 2014, 55(4), 629–640; doi:10.1093/jrr/rru019.Epub 2014 May 3. PMID: 24794798; PMCID: PMC4100010.
- Leenhouts, H. P. and Chadwick, K. H., The molecular basis of stochastic and nonstochastic effects. Health Phys., 1989, 57, 343–348.
- Morton, L. M., Onel, K., Curtis, R. E., Hungate, E. A. and Armstrong, G. T., The rising incidence of second cancers: patterns of occurrence and identification of risk factors for children and adults. Am. Soc. Clin. Oncol. Educ. Book, 2014, e57–e67; doi:10.14694/EdBook_AM.2014.34.e57.
- Dracham, C. B., Shankar, A. and Madan, R., Radiation induced secondary malignancies: a review article. Radiat. Oncol. J., 2018, 36, 85–94.
- Berrington de Gonzalez, A. et al., Second solid cancers after radiation therapy: a systematic review of the epidemiologic studies of the radiation dose-response relationship. Int. J. Radiat. Oncol. Biol. Phys., 2013, 86, 224–233.
- Synthesis and Antimicrobial Evaluation of Some Novel 1,5 Benzodiazepine Derivatives Derived from Pyrrolyl Chalcones
Abstract Views :152 |
PDF Views:0
Authors
Pankaj Kumar
1,
Abhishek Kumar
1,
Jean Sandra Pinto
1,
Sachin A. Kumbar
1,
Nanditha Bhat
1,
Prashant Nayak
2
Affiliations
1 Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte-575018, Mangaluru, Karnataka,, IN
2 Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte-575018, Mangaluru, Karnataka,, IN
1 Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte-575018, Mangaluru, Karnataka,, IN
2 Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte-575018, Mangaluru, Karnataka,, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 4 (2022), Pagination: 1811-1814Abstract
The α,β unsaturated ketone 3-(2,4-dimethyl-1H-pyrrol-3-yl)-1-phenylprop-2-en-1-onederivatives were treated with benzene-1,2-diamine to obtain 2-(2,4-dimethyl-1H-pyrrol-3-yl)-4-phenyl-2,3-dihydro-1H-benzo[b][1,4]diazepine derivatives. These synthesized compound were characterized by IR, 1H NMR, and mass spectroscopy. These synthesized molecules were evaluated for invitro antimicrobial activity. All The synthesized compounds, showed potent anti-microbial activity as compare to reference drug. In these study the synthesized were docked with Type IIA topoisomerases 2XCT using glide dock program and binding affinity were predicted for the synthesized compounds. The compound AP8 and AP9 have shown more active as per binding energy.Keywords
Benzodiazepines, Antimicrobial, Docking, Topoisomerases, o-Phenylenediamine.References
- Ilango SS, Remya PU, Ponnuswamy S. Synthesis, and antimicrobial activity of novel 1,5-benzodiazepines. Indian. J. Chem., 2013; 52B: 136-140.
- De Sarro G, Gitto R, Rizzo M., Zappia M., De Sarro A. 1,4-Benzodiazepine derivatives as anticonvulsant agents in DBA/2 mice. Gen. Pharmacol.1996; 27(6):935-941. DOI: 10.1016/0306-3623(95)02147-7
- Najafi N, Pirali M, Dowlatabadi R, Bagheri M, Rastkari N, Abdollahi M. Synthesis and analgesic and anti-inflammatory properties of new benzodiazepine derivatives. Pharmaceutical Chemistry Journal. 2005; 39(12):641-3. DOI :10.1007/s11094-006-0036-4
- Tardibono LP, Miller MJ. Synthesis and anticancer activity of new hydroxamic acid containing 1,4 benzodiazepines. Org. Lett., 2009; 11(7):1575-1578. DOI :10.1021/ol900210h
- Burmaoglu S, Algul O, Gobek A, Aktas AD, Ulger M. Aslan, G. Design of potent fluoro-substituted chalcones as antimicrobial agents. J. Enzyme. Inhib. Med. Chem., 2107; 32(1):490-495. DOI: 10.1080/14756366.2016.1265517
- Hans RH, Guantai EM., Lategan C, Smith PJ, Synthesis, antimalarial and antitubercular activity of acetylenic chalcones. Bioorg. Medicinal. Chem Lett .2010; 20(3):942-944. DOI: 10.1016/j.bmcl.2009.12.062
- Syam S, Abdelwahab SI, Al-Mamary MA, Mohan S. Synthesis of chalcones with anticancer activities. Molecules. 2012;17(6):6179-95. DOI: 10.3390/molecules17066179
- Tavadyan LA, Manukyan ZH, Harutyunyan LH, Musayelyan MV, Sahakyan AD, Tonikyan HG. Antioxidant properties of selenophene, thiophene and their aminocarbonitrile derivatives. Antioxidants. 2017;6(2):22. DOI: 10.3390/antiox6020022
- Nowakowsk Z. A review of anti-infective and anti-inflammatory chalcones. Eur. J. Med. Chem. 2007, 42(2):125-137. DOI: 10.1016/j.ejmech.2006.09.019
- Kumar P, Fernandes J, Kumar A. Synthesis and Antimicrobial Evaluation of Substituted Oxazolidinones Moieties. Res. J. Pharm. Technol. 2017;10(1):98-100. DOI: 10.5958/0974-360X.2017.00023.3
- Kumar P, Kumar A, Nayak P. Synthesis and Antimicrobial evaluation of Some novel Mercapto Pyrimidine via Pyrrole chalcone. Res. J. Pharm. Technol. 2018;11(7):2765-7. DOI: 10.5958/0974-360X.2018.00511.5