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Sabale, Prafulla M
- Amino-indane: Fused Heterocycle with Diverse Pharmacological Activity
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Authors
Affiliations
1 Department of Pharma. Chemistry, Parul Institute of Pharmacy, Limda-391 760, Vadodara, Gujarat, IN
2 Darshan Pharma Chem, Plot No. A-1/3621, GIDC Estate, Ankeleshwar Gujarat, IN
1 Department of Pharma. Chemistry, Parul Institute of Pharmacy, Limda-391 760, Vadodara, Gujarat, IN
2 Darshan Pharma Chem, Plot No. A-1/3621, GIDC Estate, Ankeleshwar Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 6, No 5 (2013), Pagination: 438-447Abstract
Amino-indane is an important structural moiety found in numerous pharmaceutically active compounds. Aminoindane has non-heterocyclic fused ring having six member benzene ring and five member cyclopentane ring with amino group. Amino-indane derivatives play a vital role in the field of medicinal chemistry. This has the important place to synthesis of class of different pharmacological activities. Amino-indane moiety is an important pharmacophore and exhibits outstanding biological activities. A number indane derivatives have acquired a special place in heterocyclic field because of their diversified activities such as antimicrobial, antipyretic, analgesic, anticonvulsant, CNS Depressant anti-inflammatory, anticancer activity. This review emphasized the recent researches in amino-indanes in various diseases and disorders.Keywords
Indane, Amino-indane, Anti-inflammatory, Pharmacological Activity
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- 1,2,3,4-Tetrahydroquinoline Derivatives and its Significance in Medicinal Chemistry
Abstract Views :563 |
PDF Views:8
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Parul Institute of Pharmacy, Limda-391 760, Vadodara, Gujarat, IN
1 Department of Pharmaceutical Chemistry, Parul Institute of Pharmacy, Limda-391 760, Vadodara, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 6, No 6 (2013), Pagination: 599-610Abstract
1,2,3,4-Tetrahydroquinoline derivatives are the most important class of compounds in the pharmaceutical and agrochemical industries and play important role in the field of medicinal chemistry with so many Pharmacological activities such as anti-cancer, anti-diabetic, anti-parasitic, anti-inflammatory, anti-oxidant, adrenergic, anti-HIV, antialzheimer, anti-hyperlipidemic, activities. The tetrahydroquinoline ring containing system found in numerous biologically active natural products and pharmacologically relevant therapeutic agents and very common structure motif. Because of the significance of these scaffolds in medicinal chemistry, the development of some potent and important amalgams continues to be a very active field in development of a promising target for new drug development. 1,2,3,4-Tetrahydroquinoline is one such important part of pharmacophore and having different pharmacological activities. Here we have introduced different 1,2,3,4-tetrahydroquinoline derivatives which possess different biological activities depends on its types and position of substituted functional groups. This review is summarized to know about the chemistry of different 1,2,3,4-tetrahydroquinoline derivatives along with their pharmacological activities.Keywords
1,2,3,4-tetrahydroquinoline, Anti-cancer, Anti-cancer, Anti-diabetic, Anti-parasitic, AntiinflammatoryReferences
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