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Co-Authors
- Balveer Singh
- Ashok Saini
- Jyotsna
- Swati Haldar
- Jagmohan Singh
- Mavurapu Satyanarayana
- Prem C. Verma
- Jaya Tiwari
- Atma P. Dwivedi
- Rohit Srivastava
- Neha Rehuja
- Swayam P. Srivastava
- Sudeep Gautam
- Akhilesh K. Tamrakar
- Anil K. Dwivedi
- Hari N. Kushwaha
- Nagsen Gautam
- Shio K. Singh
- Mukesh Srivastava
- Chandishwar Nath
- Ram Raghubir
- Arvind K. Srivastava
- Ram Pratap
- Asha Khanna
- Shajiya Tabassum
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Shukla, Poonam
- Efficient PCR-Based Epitope Gene Tagging in Schizosaccharomyces pombe
Abstract Views :277 |
PDF Views:97
Authors
Affiliations
1 Institute of Microbial Technology, Sector 39A, Chandigarh 160 036, IN
1 Institute of Microbial Technology, Sector 39A, Chandigarh 160 036, IN
Source
Current Science, Vol 110, No 2 (2016), Pagination: 146-148Abstract
No Abstract.Full Text
- Chalcone-Based Aryloxypropanolamine as a Potential Antidiabetic and Antidyslipidaemic Agent
Abstract Views :294 |
PDF Views:82
Authors
Poonam Shukla
1,
Mavurapu Satyanarayana
1,
Prem C. Verma
1,
Jaya Tiwari
1,
Atma P. Dwivedi
1,
Rohit Srivastava
2,
Neha Rehuja
2,
Swayam P. Srivastava
2,
Sudeep Gautam
2,
Akhilesh K. Tamrakar
2,
Anil K. Dwivedi
3,
Hari N. Kushwaha
4,
Nagsen Gautam
4,
Shio K. Singh
4,
Mukesh Srivastava
5,
Chandishwar Nath
6,
Ram Raghubir
7,
Arvind K. Srivastava
2,
Ram Pratap
8
Affiliations
1 Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
2 Division of Biochemistry, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
3 Division of Pharmaceutics, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
4 Division of Pharmacokinetics and Pharmaco-Dynamics, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
5 Division of Biometry and Statistics, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
6 Division of Toxicology, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
7 Division of Pharmacology, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
8 Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031
1 Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
2 Division of Biochemistry, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
3 Division of Pharmaceutics, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
4 Division of Pharmacokinetics and Pharmaco-Dynamics, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
5 Division of Biometry and Statistics, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
6 Division of Toxicology, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
7 Division of Pharmacology, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
8 Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031
Source
Current Science, Vol 112, No 08 (2017), Pagination: 1675-1689Abstract
The hybrid congener 3 derived from hydroxychalcone and pharmacophore oxypropanolamine for adrenergic receptor, along with its enantiomers 9a and 9b were selected from a series of compounds for detailed studies of their antidiabetic profile in sucrose-challenged, low-dosed, streptozotocin-induced diabetic rats and in db/db mice, and antidyslipidaemic profile in high fat diet-induced dyslipidaemic hamsters. The test compounds exhibited significant and consistent antidiabetic and antidyslipidaemic activities in the above models. The pharmacodynamic studies of two metabolites, 10 and 11, were undertaken. Metabolite 10 having greater bioavailability in plasma was synthesized and found to exhibit significant antidiabetic activity. The parent compound together with its active metabolites exhibited significant oral bioavailability, thus establishing compound 3 as a potential lead molecule for further studies.Keywords
Antidiabetic and Antidyslipidaemic Activity, Chalcone, Diabetes Mellitus, Metabolites, Rodents.Full Text
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- Role of Ocimum sanctum as a Genoprotective Agent on Chlorpyrifos-Induced Genotoxicity
Abstract Views :166 |
PDF Views:0
Authors
Affiliations
1 Department of Zoology and Biotechnology, St. Aloysius’ College, IN
2 Government Science College, Pachpedi, Jabalpur, MP, IN
3 Mata Gujri Women’s College, Jabalpur, Madhya Pradesh, IN
1 Department of Zoology and Biotechnology, St. Aloysius’ College, IN
2 Government Science College, Pachpedi, Jabalpur, MP, IN
3 Mata Gujri Women’s College, Jabalpur, Madhya Pradesh, IN
