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Udavant, Pavan
- Synthesis and Evaluation of Antidiabetic Activity of Few 5-(4-(5-Substitutedphenyl)-1,3,4-Oxadiazlole-2-Yl) Methoxy)Benzylidene) Thiazolidine 2,4-Dione Derivatives
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Authors
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1 MET’S Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik-422003, Savitribai Phule Pune University, IN
1 MET’S Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik-422003, Savitribai Phule Pune University, IN
Source
Asian Journal of Pharmaceutical Research, Vol 7, No 4 (2017), Pagination: 261-264Abstract
The aim of study was to synthesize a new series of Thiazolidinedione. Thiazolidinedione or glitziness forms a significant class of drug which exhibit biological activities ranging from antidiabetic, antiinflamatory, antibacterial, antifungal, antiviral, and anti-cancer. In the present study reported a systematic synthesis of thiazolidinedione. A new series of 2,4-thiazolidinedione based derivative have been synthesize by condensation of. The structure of these compounds were establish by IR and 1H NMR. These new compound (C1-C4) were evaluated for their antidiabetic activity on albino rat. Most of compound shows significant antidiabetic activity when compare with standard drug metformin.Keywords
Diabetic Mellitus, Thiazolidinedione, Antidiabetic Activity.References
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