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Jayaprakash, P.
- Molecular Docking Study of Bark-derived Components of Cinnamomum Cassia on Aldose Reductase
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PDF Views:193
Authors
Affiliations
1 Dept. of Zoology, Presidency College, Chennai–600005, IN
2 Dept. of Biotechnology, Sri Venkateswara College of Engineering, Chennai-602105, IN
1 Dept. of Zoology, Presidency College, Chennai–600005, IN
2 Dept. of Biotechnology, Sri Venkateswara College of Engineering, Chennai-602105, IN
Source
Indian Journal of Science and Technology, Vol 3, No 10 (2010), Pagination: 1081-1088Abstract
Aldose reductase (AR) is an enzyme associated with retinopathy of both type 1 and type 2 diabetic patients. AR is inhibited by giving chemical drugs to prevent diabetic retinopathy, but is associated with deleterious side effects. Compounds isolated from plants are safer than chemical drugs and have a lot of potential. In the present study, three components viz., cinnamaldehyde, cinnamic acid and cinnamyl alcohol derived from the bark of Cinnamomum cassia were used to evaluate their efficiency in inhibiting AR activity. For this, the AR protein structure database was downloaded from PDB and its pictorial database was downloaded from PDBsum. Structural visualization of AR was done by RasMol. Using Q-SiteFinder, prediction of ligand binding site was done. The three dimensional structures of inhibitors viz., cinnamaldehyde, cinnamic acid and cinnamyl alcohol were downloaded from ChemSketch. Docking studies were carried out using ArgusLab software. Docking studies of cinnamaldehyde, cinnamic acid and cinnamyl alcohol against AR was undertaken to gain insight into the binding mode of the investigated compounds at the active site of AR. All compounds were found to be active against AR as indicated by docking results; the best being cinnamaldehyde. Results suggest that cinnamaldehyde, cinnamic acid and cinnamyl alcohol should be evaluated further for therapeutic use in combination with other diabetic drugs. Further, this may be confirmed by drug trials in animal models to find out the optimum dose and its efficiency in inhibiting AR activity to treat diabetic related complicationsKeywords
Diabetes, Aldose Reductase, Cinnamon, Molecular DockingFull Text
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- Developing Telugu Speech Recognition System Using Sphinx-4
Abstract Views :191 |
PDF Views:4
Authors
Affiliations
1 SVPCET, Puttur, IN
1 SVPCET, Puttur, IN
Source
Artificial Intelligent Systems and Machine Learning, Vol 2, No 12 (2010), Pagination:Abstract
Speech is the main communication medium in Human beings. Speech recognition has many applications. It can be used to automate many tasks that previously required hands-on human interaction. Many speech recognition systems have been proposed and developed. Sphinx4 is one such system developed in Java for recognizing English. In this paper how speech recognition is done is presented briefly and then sphinx4 architecture is explained. This paper aims at installing sphinx4 and testing it. Sphinx4 was used to develop applications for Telugu. This is done by identifying the language dependent areas of the sphinx4 and their interactions with other parts of the system and then modifying these areas so that it works for Telugu. Static Dictionary for Telugu words is developed rather than using online ‘lmtool’ of CMU. Sphinx4 was adapted to train and decode for recognizing isolated Telugu words. Continuing in a similar manner, a speech recognition system for Telugu can be developed.Keywords
Melfrequency Cepstral Coefficients, Hidden Markov Models, Language Model, N-Grams.
- SRF based control of single stage dual purpose three-phase grid integrated solar PV system
Abstract Views :171 |
PDF Views:0
Authors
Affiliations
1 Dept. of Electrical and Electronics Engineering, Govt. College of Engineering, Kannur, IN
1 Dept. of Electrical and Electronics Engineering, Govt. College of Engineering, Kannur, IN