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Gadhave, P. D.
- Clinicopathological Studies on Vitamin D3 Toxicity and Therapeutic Evaluation of Aloe vera in Rats
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Authors
Sambhaji G. Chavhan
1,
R. S. Brar
1,
H. S. Banga
1,
H. S. Sandhu
2,
S. Sodhi
1,
P. D. Gadhave
1,
V. R. Kothule
1
Affiliations
1 Departments of Veterinary Pathology, GADVASU, Ludhiana - 141 004, Punjab, IN
2 Departments of Veterinary Pharmacology and Toxicology, GADVASU, Ludhiana - 141 004, Punjab, IN
1 Departments of Veterinary Pathology, GADVASU, Ludhiana - 141 004, Punjab, IN
2 Departments of Veterinary Pharmacology and Toxicology, GADVASU, Ludhiana - 141 004, Punjab, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 18, No 1 (2011), Pagination: 35-43Abstract
A study was conducted to examine the clinical signs, hematological, biochemical and histopathological changes in vitamin D3 toxicity at a dose rate 2 mg/kg b.wt. of vitamin D3 and to assess the protective effect of Aloe vera in vitamin D3 toxicity. The clinical signs observed were anorexia, progressive weight loss, difficulty in movement and respiration, diarrhea, epistaxis, subnormal body temperature and nervous signs before death. Mortality was observed in treated rats between day 10 and day 19 of treatment. The gross postmortem changes observed were severe emaciation, white chalky deposits on epicardial surface of heart, pin point white deposits on cortical surface of kidneys with pale yellow discoloration and diffused white deposits on serosal surface of stomach and intestine with bloody ingesta in lumen. The hematological changes included non-significant increase in hemoglobin and total leukocyte count and significant increase in relative neutrophil count. The biochemical changes observed were significant increase in plasma concentration of calcium, phosphorus and blood urea nitrogen, whereas a significant decrease in the concentration of albumin and total plasma protein was observed. The histopathological lesions included calcification of various organs, viz., tongue, stomach, intestines, kidney, heart, aorta, larynx, trachea, lungs, spleen, choroid plexus arteries of brain and vas deferens. The Aloe vera juice (2.5% in drinking water) has no protective effect on vitamin D3 toxicity (2 mg/kg b.wt.).Keywords
Aloe vera, calcification, histopathological lesions, hypercalcemia, vitamin D3 toxicity
- A Case of Intranasal Hemangioma and Concurrent Tetracycline-induced Ulcerative Gastritis in Dogs
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Authors
Affiliations
1 Department of Veterinary Pathology, College of Veterinary Science, GADVASU, Ludhiana - 141 004, Punjab, IN
2 Department of Veterinary Pathology, College of Veterinary Science, GADVASU, Ludhiana - 141 004, Punjab
3 Department of Pharmacology and Toxicology, College of Veterinary Science, GADVASU, Ludhiana - 141 004, Punjab, IN
1 Department of Veterinary Pathology, College of Veterinary Science, GADVASU, Ludhiana - 141 004, Punjab, IN
2 Department of Veterinary Pathology, College of Veterinary Science, GADVASU, Ludhiana - 141 004, Punjab
3 Department of Pharmacology and Toxicology, College of Veterinary Science, GADVASU, Ludhiana - 141 004, Punjab, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 17, No 1 (2010), Pagination: 33-36Abstract
Incidence of drug-induced gastritis and ulceration in human medicine is well established. Besides, unilateral hemangioma, a unique concurrent case of tetracycline induced gastric toxicity in a dog, characterized by gastritis and ulceration is being reported here. Grossly, the appearance of gastric ulcers mimicked the appearance of Italian pizza. Histological examination further supported drug-induced etiology in this case. This is probably the one of the few cases in the annals of veterinary medicine to be documented as drug-induced gastric toxicity in dog.Keywords
Dogs, doxycycline, gastritis, histopathology, tetracyclines- An Acute Toxicity Study of Tylophora Indica Leaves Extract in Wistar Rats
Abstract Views :225 |
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Authors
Affiliations
1 Department of Veterinary Pathology, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, IN
2 Department of Veterinary Pathology, Maharashtra Animal and Fishery Sciences University, MAFSU, Nagpur – 440006, Maharashtra, IN
3 Department of Zoology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab – 144411, IN
4 Department of Veterinary Public Health, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, IN
5 Department of Veterinary Pharmacology and Toxicology, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, IN
6 Hospital Registrar, TVCC Complex, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, IN
1 Department of Veterinary Pathology, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, IN
2 Department of Veterinary Pathology, Maharashtra Animal and Fishery Sciences University, MAFSU, Nagpur – 440006, Maharashtra, IN
3 Department of Zoology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab – 144411, IN
4 Department of Veterinary Public Health, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, IN
5 Department of Veterinary Pharmacology and Toxicology, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, IN
6 Hospital Registrar, TVCC Complex, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 25, No 3 (2018), Pagination: 163-168Abstract
The present investigation was carried out to evaluate the safety of hydroalcoholic extract of Tylophora indica leaves after single dose administration to determine its potential toxicity individually as per Organisation for Economic Co-operation and Development [OECD] 423 guideline. General behaviour, adverse effects and mortality parameters were studied for up to 14 days. Extract was found safe at the oral doses of 2000 mg/kg b. wt. There were no apparent toxicity signs and death observed during experimental trial. Gross necropsy examination revealed no abnormal lesions. In view of the dose of Tylophora indica leaves consumed in traditional medicine, it is observed that there is a wide margin of safety for the therapeutic use.Keywords
Acute Toxicity, OECD Guideline 423, Tylophora Indica, Wistar Rats.References
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