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N. D. Singh ¹, H. S. Banga ¹, P. D. Gadhave ¹, A. A. Chougule ¹, A. Goyal ¹, R. S. Brar ¹

Affiliations
1 Department of Veterinary Pathology, College of Veterinary Science GADVASU, Ludhiana-141 004, IN

Abstract

A five-year-old Holstein Friesian cow was presented to Teaching Veterinary Clinical Complex, College of Veterinary Science, GADVASU, Ludhiana with a history of tick infestation and high fever. Hematological examination revealed severe Anaplasma marginale infection with reduction in hemoglobin (2 gm/dl), total erythrocyte count (1x10⁶ cells/cu mm) and packed cell volume (6%) with absolute neutrophilia and highly activated platelets. The animal died the next day and sent for post mortem examination. Grossly the carcass was anemic and icteric. There was enlargement of spleen and petechial hemorrhages on heart and kidney. Histopathologically spleen showed lymphoid depletion and hemosiderosis. Kidney revealed tubular degeneration and necrosis besides interstitial hemorrhages. Fatty changes and mild hemorrhages besidesbiliary retention were observed in liver. Myocardial hemorrhages were also evident.

Keywords

Anaplasma marginale, Hemoglobin, Hemosiderosis, Neutrophilia.

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Sambhaji G. Chavhan ¹, R. S. Brar ¹, H. S. Banga ¹, H. S. Sandhu ², S. Sodhi ¹, P. D. Gadhave ¹, V. R. Kothule ¹

Affiliations
1 Departments of Veterinary Pathology, GADVASU, Ludhiana - 141 004, Punjab, IN
2 Departments of Veterinary Pharmacology and Toxicology, GADVASU, Ludhiana - 141 004, Punjab, IN

Abstract

A study was conducted to examine the clinical signs, hematological, biochemical and histopathological changes in vitamin D₃ toxicity at a dose rate 2 mg/kg b.wt. of vitamin D₃ and to assess the protective effect of Aloe vera in vitamin D₃ toxicity. The clinical signs observed were anorexia, progressive weight loss, difficulty in movement and respiration, diarrhea, epistaxis, subnormal body temperature and nervous signs before death. Mortality was observed in treated rats between day 10 and day 19 of treatment. The gross postmortem changes observed were severe emaciation, white chalky deposits on epicardial surface of heart, pin point white deposits on cortical surface of kidneys with pale yellow discoloration and diffused white deposits on serosal surface of stomach and intestine with bloody ingesta in lumen. The hematological changes included non-significant increase in hemoglobin and total leukocyte count and significant increase in relative neutrophil count. The biochemical changes observed were significant increase in plasma concentration of calcium, phosphorus and blood urea nitrogen, whereas a significant decrease in the concentration of albumin and total plasma protein was observed. The histopathological lesions included calcification of various organs, viz., tongue, stomach, intestines, kidney, heart, aorta, larynx, trachea, lungs, spleen, choroid plexus arteries of brain and vas deferens. The Aloe vera juice (2.5% in drinking water) has no protective effect on vitamin D₃ toxicity (2 mg/kg b.wt.).

Keywords

Aloe vera, calcification, histopathological lesions, hypercalcemia, vitamin D₃ toxicity

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H. S. Banga ¹, S. Deshmukh ¹, R. S. Brar ¹, P. D. Gadhave ¹, S. G. Chavhan ², H. S. Sandhu ³

Affiliations
1 Department of Veterinary Pathology, College of Veterinary Science, GADVASU, Ludhiana - 141 004, Punjab, IN
2 Department of Veterinary Pathology, College of Veterinary Science, GADVASU, Ludhiana - 141 004, Punjab
3 Department of Pharmacology and Toxicology, College of Veterinary Science, GADVASU, Ludhiana - 141 004, Punjab, IN

Abstract

Incidence of drug-induced gastritis and ulceration in human medicine is well established. Besides, unilateral hemangioma, a unique concurrent case of tetracycline induced gastric toxicity in a dog, characterized by gastritis and ulceration is being reported here. Grossly, the appearance of gastric ulcers mimicked the appearance of Italian pizza. Histological examination further supported drug-induced etiology in this case. This is probably the one of the few cases in the annals of veterinary medicine to be documented as drug-induced gastric toxicity in dog.

Keywords

Dogs, doxycycline, gastritis, histopathology, tetracyclines

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