Informatics Publishing Limited

M. J. Amar Dev , N. Rajarajeshwari , S. Ganapaty , B. Parixi , R. Brun

Abstract

The genus Diospyros is a rich source for napthols and naphthoquinones. During the study, we have chemically examined the ischolar_mains of three unexplored species of Diospyros, D. oocarpa, D. nigresence and D. candolleana for their chemical profile and biological activities. The plant materials on conventional extractions with organic solvents and sequential chromatography yielded seven naphthoquinone derivatves, habibone [1], 8'-hydroxyisodiospyrin [2], diospyrin [3], 4-hydroxy-5methoxy-2-naphthaldehyde [4], 5-hydroxy-4-methoxy-2-naphthaldehyde [5], 4- hydroxy-3,5-dimethoxy-2-naphthaldehyde [6], and 2-methyl anthraquinone [7] These isolates were characterized by spectral data (2D NMR, ¹H-¹H COSY and ¹³C-¹H COSY). In addition, these compounds were evaluated for their potential to inhibit parasitic protozoa belonging to the genera Trypanosoma, Leishmania and Plasmodium using in vitro antiprotozoal assay and anthelmintic activity against adult earth worms, Pheritima posthuma. The study showed that the isolates enjoy significant anthelmintic and antiprotozoal activity and supports its use in folk medicine.

Keywords

Anthelmintic, Antiprotozoal, Naphthoquinones, D. oocarpa, D. nigresence, and D. candolleana

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Ravi Kumar ¹, N. Rajarajeshwari ²

Affiliations
1 JJT University, ZhunZhunu- Rajasthan, IN
2 Visveswarapura Institute of Pharmaceutical Sciences, Bangalore, IN

Abstract

Plant products serve as an alternative to synthetic products because of local accessibility, eco friendly nature and lower price compared to imported synthetic products. Natural gums and mucilage have been widely explored as pharmaceutical excipients. Tablet disintegration has received considerable attention as an essential step in obtaining fast drug release. The present study was undertaken to isolate mucilage from Borassus flabellifer endosperm and explored its use as disintegrant by formulating tablets of metformin. Extracted Mucilage was subjected to toxicity studies for its safety and preformulation studies for its suitability as a disintegrating agent. The extracted mucilage is devoid of toxicity. No chemical interaction between drug and excipients was confirmed by FTIR, TLC and DSC studies. Mouth dissolving tablets of metformin were prepared and compared with different concentrations viz; 0.5,1, 1.5, 2.0 and 2.5%(w/w) of Borassus flabellifer mucilage powder and Ac-Di-Sol®. The prepared tablets were characterized by FTIR, TLC and DSC studies. Ten formulations were prepared and evaluated for physical parameters such as thickness, hardness, friability, weight variation, drug content, disintegration time and drug dissolution. The formulated tablets had good appearance and better drug release properties. The study revealed that Borassus flabellifer mucilage powder was effective as disintegrant in low concentrations (1%). The mucilage was found to be a superior disintegrating agent than Ac-Di-Sol®. Studies indicate that the extracted mucilage may be a good source of pharmaceutical adjuvant, specifically a disintegrating agent.

Keywords

Borassus flabellifer Mucilage, Natural Excipient, Metformin HCL, Disintegrant, Croscarmellose Sodium.

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