Informatics Publishing Limited

Abdul Saleem Mohammad ¹, Nuha Rasheed ², Mohammed Nayeem Uddin ³, Hajera Hafeez ⁴

Affiliations
1 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
2 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
3 Department of Pharmacology, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
4 Department of Pharmaceutics, Global College of Pharmacy, Beside to Moinabad Police Station, Moinabad, Ranga Reddy (Dist)-501504, Telangana, IN

Abstract

The aim of present study confirmed that the SEDDS formulation can be used as a possible alternate to traditional or classical formulations of Ibuprofen to improve its bioavailability using varied quantities of goat fat as an excipient and tween 60 as a surfactant which is a drug in the nonsteroidal anti-inflammatory drug (NSAID) class used for treating pain, fever and inflammation which is also known to be isobutylphenylpropanoic acid. The investigation proved that the formulated dosage forms showed good release profile as well as acceptable tablet properties. The batches with higher tween60: goat fat content ratios gave better release rates. The SEDDS of Ibuprofen was successfully prepared and the tablets prepared passed the various evaluation tests conducted. This method has advantage of reliance on cheap raw materials such as goat fat with fewer processing steps, best suited for lipophilic drugs where the resulting emulsification gives faster dissolution rates and absorption. Invivo evaluation of this novel dosage form is currently in progress. Self-emulsifying drug delivery systems are a promising approach for the formulation of lipophilic drug compounds having poor aqueous solubility. The oral delivery of hydrophobic drugs can be made possible by SEDDSs which have been shown to improve oral bioavailability substantially. From the formulation point of view it is necessary to consider the emulsification properties of lipid base vehicle and the solubility of drug in the lipid surfactant mixture to form a completely miscible solution so as to solubilize adequate quantities of drug in lipid vehicle. Lipids have an important role in absorption process. Thus, SEDDS plays an important role in the formulation of poorly water soluble drugs and enhancing their bioavailability.

Keywords

SEEDS, Surfactants, Tween-60, Goat Fat, Beer's Law, Lipophilic.

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Abdul Saleem Mohammad ¹, Nuha Rasheed ², Hajera Hafeez ³, Mohammed Nayeem Uddin ⁴

Affiliations
1 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V)-508284, Pochampally (M), Behind Mount Opera, Yadadri Bhuvanagiri (Dist), Telangana, IN
2 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V)-508284, Pochampally (M), Behind Mount Opera, Yadadri Bhuvanagiri (Dist), Telangana, IN
3 Department of Pharmaceutics, Global College of Pharmacy, Beside to Moinabad Police Station, Moinabad-501504, Rangareddi (Dist), Telangana, IN
4 Department of Pharmacology, Nizam Institute of Pharmacy, Deshmukhi (V)-508284, Pochampally (M), Behind Mount Opera, Yadadri Bhuvanagiri (Dist), Telangana, IN

Abstract

Generally, a product manager manages one or more tangible products. However, the term may be used to describe a person who manages intangible products, such as music, information, and services. A product manager's role in tangible goods industries is similar to a program director's role in service industries. Diverse interpretations regarding the role of the product manager are the norm. The product manager title is often used in many ways to describe drastically different duties and responsibilities. Even within the high-tech industry where product management is better defined, the product manager's job description varies widely among companies. This is due to tradition and intuitive interpretations by different individuals. A product manager communicates product vision from the highest levels of executive leadership to development and implementation teams. The product manager is often called the product "CEO". The product manager investigates, selects, and drives the development of products for an organization, performing the activities of product management. A product manager considers numerous factors such as intended demographic, the products offered by the competition, and how well the product fits with the company's business model. The product manager is often considered the CEO of the product and is responsible for the strategy, roadmap, and feature definition for that product or product line. The position may also include marketing, forecasting, and profit and loss (P&L) responsibilities.

Keywords

CEO, Manager, Product, Executive, Responsibilities, Industry.

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