A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Junaid, Md.
- Drug Bank:An Update-Resource for in Silico Drug Discovery
Authors
1 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 3 (2012), Pagination: 166-171Abstract
Drug Bank plays a vital role in the research of bioinformatics/chemo informatics. Drug bank is a richly annotated resource that combines detailed drug data with comprehensive drug target and drug action information. Since its first release in the 2006, Drug Bank has been widely used to facilitate, in silico drug target discovery, drug design, drug docking or screening, drug metabolism prediction, drug interaction prediction and general pharmacological education. First drug bank was released in 2006 with version 1.0. Now it is successfully updated by the releasing of 2.0, 2.5 and 3.0 version. First released in 2006, Drug Bank has become widely used by pharmacists, medicinal chemists, pharmaceutical researchers, clinicians, educators and the general public . The database contains 6707 drug entries including 1436 FDA-approved small molecule drugs, 134 FDA-approved biotech (protein/peptide) drugs, 83 nutraceuticals and 5086 experimental drugs. Additionally, 4228 non-redundant protein (i.e. drug target/enzyme/transporter/carrier) sequences are linked to these drug entries. Each DrugCard entry contains more than 150 data fields with half of the information being devoted to drug/chemical data and the other half devoted to drug target or protein data. Since its last update in 2008, DrugBank has been greatly expanded through the addition of new drugs, new targets and the inclusion of more than 40 new data fields per drug entry (a 40% increase in data 'depth'). These data field additions include illustrated drug-action pathways, drug transporter data, drug metabolite data, pharmacogenomic data, adverse drug response data, ADMET data, pharmacokinetic data, computed property data and chemical classification data. Drug Bank 3.0 also offers expanded database links, improved search tools for drug-drug and food-drug interaction, new resources for querying and viewing drug pathways and hundreds of new drug entries with detailed patent, pricing and manufacturer data. These additions have been complemented by enhancements to the quality and quantity of existing data, particularly with regard to drug target, drug description and drug action data. Drug Bank 3.0 represents the result of 2 years of manual annotation work aimed at making the database much more useful for a wide range of 'Omics' (i.e. pharmacogenomic, pharmacoproteomic, pharmacometabolomic and even pharmacoeconomic) applications.
Keywords
Drug Bank, Database, In silico Drug Discovery.
- Sexual Offence against Children and Legislative Protection in India:An Introduction
Authors
1 Dept. of Law – Aligarh Muslim University, Murshidabad Centre, West Bengal, IN
2 Department of Law – Aligarh Muslim University, Murshidabad Centre, West Bengal, IN
Source
Indian Journal of Society and Politics, Vol 4, No 1 (2017), Pagination: 75-84Abstract
Sexual offences against the children has always been a hidden problem in India and largely been ignored in public discourse making the issue more severe and complex. Only recently, it has been acknowledged as a major threat to the wellbeing of the children in India. In India, there has been very less understanding of the extent, magnitude and trends of this complex and rigid problem. The growing complexities of life and the dramatic changes brought about by socio - economic transition in the society have played a major role in increasing the vulnerability of the children to various and newer forms of abuse. Keeping the development of this intricacy trends in the society, the Government in order to combat with this social evil, brought in a special law - the Protection of Children from Sexual Offences (POCSO) Act, 2012 criminalizing a range of serious acts to safeguard the interest of the children. The Act brought in a lot of magnificent changes in the practice of dealing the sensitive matters related to children. In the present paper, the authors firstly will discuss the status quo of the crime against children in India; secondly will analyse the provisions of POCSO Act, 2012; thirdly will filter the NCRB Data on the crime against the children; fourthly will discuss the issues and challenges against the newly enacted POCSO Act, 2012.Keywords
India, Children, Sexual Offences, POCSO.Full Text
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