Informatics Publishing Limited

Mai Gad ¹, Amany Abou-Bakr ², Rasha Mahmoud Allam ³, Hanan Ramdan Nassar ⁴, Maher H. Ibraheem ⁵, Soha Talima ⁶, Ghada Mohamed ⁷

Affiliations
1 Assistant Lecturer, Department of surgical Pathology, National Cancer Institute, Cairo University, EG
2 Professor, Author, National Cancer Institute, Surgical Pathology Department, Cairo University, EG
3 Lecturer, Author, Biostatistics and Cancer Epidemiology Department National Cancer Institute, Cairo University, EG
4 Professor, Medical Oncology Department, National Cancer Institute, Cairo University, EG
5 Lecturer, Surgical Oncology Department, National Cancer Institute, Cairo University, EG
6 Assistant Professor, Clinical Oncology Department (NEMROCK), Faculty of Medicine, Cairo University, EG
7 Lecturer, National Cancer Institute, Surgical Pathology Department, Cairo University, EG

Abstract

We aimed in this study to detect the correlation between PD-L1 and TILs, and their relationship with clinical outcome and survival in Egyptian patients with HGSOC.

Immunohistochemical expression of PD-L1, CD4 and CD8 was investigated in 94 HGSOC Egyptian patients. PD-L1 immunoreactivity was detected in 24% of the cases. The lack of tumor PD-L1 expression proved to be an independent predictive factor for better overall survival (OS) (p=0.01). Moreover, high stromal CD8 + TILs density had a significant impact on better disease-free survival (p=0.007). Patients who showed negative expression of PD-L1 and high intraepithelial CD8+ TILs density lived significantly longer than other patients (p=0.021).

Keywords

PD-L1, HGSOC, TILS, CD4, CD8, Survival, Egypt.

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