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M. Vijayabaskaran ¹, G. Lakshmi ², M. Senthilraja ², P. Sivakumar ², P. Vaijayanthimala ², P. Perumal ²

Affiliations
1 Department of Pharmaceutical Chemistry, J.K.K. Nataraja College of Pharmacy, Komarapalayam-638183 Tamil Nadu, IN
2 Department of Pharmaceutical Chemistry, J.K.K. Nattraja College of Pharmacy, Komarapalayam-638183, Tamil Nadu, IN

Abstract

Indole derivatives (Isatin) are potential synthons, for building synthetically a variety of chemical systems known for their broader biological and pharmacological applications. In the present investigation, title compounds (V1-V5) were synthesized by the condensation reaction of 3-[(2)-(phenyl methylidene) hydrazono]-1, 3-dihydro-2H-benzo[g]indol-2-one (IV) with different aryl aldehydes, as such reactions are not reported so far. The synthesized compounds were characterized by IR, ¹H NMR and MASS spectroscopy. They were screened for their antimicrobial potential against bacterial strains i.e., Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Proteus vulgaris and fungal strains i.e., Candida albicans and Yeast. Compound V5 (Nitro) was more potent anti- microbial agent against both bacteria [Gram (+Ve) and Gram (-Ve) organisms] followed by compound V₄ (Chloro) and V₂ (4-Methoxy).

Keywords

Isatin, Aryl Aldehydes, Antimicrobial Activity, Bacillus subtilis, Candida albicans.

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G. Babu ¹, Thejonath Kolla ¹, K. Prasad ¹, M. Vijayabaskaran ², S. T. Latha ³

Affiliations
1 Department of Pharmaceutical Analysis, J. K. K. Nattraja College of Pharmacy, Komarapalayam – 638 183, Namakkal Dt. Tamil Nadu, IN
2 Department of Pharmaceutical Chemistry, J. K. K. Nattraja College of Pharmacy, Komarapalayam – 638 183, Namakkal Dt. Tamil Nadu, IS
3 Dep. of Pharmaceutical Chemistry, Swamy Vivekanandha College of Pharmacy, Elayampalayam – 637 205, Namakkal Dt. Tamil Nadu, IN

Abstract

A simple and specific UV derivative spectroscopy and RP-HPLC was developed for buclizine hydrochloride. These methods are carried out by using 234 nm as the wavelength and 100% v/v methanol as solvent. Second derivative spectroscopy was developed to minimize the interferences. The linearity ranges were 10-50 mcg/ml for derivative spectroscopy and 1-10 mcg/ml for the RP-HPLC respectively. Chromatographic separation was made on Phenomenex Luna C18 (250 mm × 4.6 mm, 5μ) column at room temperature with 1.0 ml/min as flow rate and the injection volume was 20 μl. The retention time was found to be 7.15 min. The high recovery and low relative standard deviation confirms the suitability of the methods for the determination of buclizine hydrochloride in pharmaceutical dosage forms.

Keywords

Buclizine Hydrochloride, UV Derivative Spectroscopy, RP-HPLC, Piperazine Derivative, Antiemetic.

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M. Vijayabaskaran ¹, G. Babu ¹, N. Venkateswaramurthy ¹, P. Sivakumar ¹, P. Perumal ¹, T. Sivakumar ², R. Sambathkumar ³, B. Jayakar ⁴

Affiliations
1 JKK Nataraja College of Pharmacy, Komarapalayam, Namakkal District, Tamil Nadu 638183, IN
2 Nandha College of Pharmacy, Erode, Tamil Nadu 638 052, IN
3 Department of Pharmaceutics, Seventh of April University, Al-Zawia City, LY
4 Vinayaka Missions College of Pharmacy, Salem, Tamil Nadu, IN

Abstract

The study was aimed at evaluating the antitumor and antioxidant activities of ethanol extract of Pseudarthria viscida (Family: Fabaceae) against Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice. The ethanol extract of Pseudarthria viscida (EEPV) was administered at the doses of 100 and 200 mg/kg in mice for 14 days after 24 h of tumor inoculation. The effect of EEPV on the growth of transplantable murine tumor, life span of EAC bearing mice, hematological profile and liver biochemical parameters were estimated. Treatment with EEPV decreased the tumor volume and viable cell count thereby increasing the life span of EAC bearing mice and brought back the hematological parameter more or less normal level. The effect of EEPV decreases the level of lipid peroxidation and protein content and significantly increased the level of antioxidant enzymes such as Catalase (CAT), Glutathione (GSH) and Superoxide dismutase (SOD). These observations are suggestive of the protective effect of EEPV against Ehrlich Ascites Carcinoma (EAC).

Keywords

Pseudarthria viscida, Ehrlich Ascites Carcinoma, Hematological Parameter, Antioxidant, Antitumor Activity.

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S. Gomathi ¹, R. Shanmuga Sundaram ², M. Vijayabaskaran ¹, C. Kannan ³, R. Sambathkumar ³

Affiliations
1 Department of Pharmaceutical Chemistry, JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal (Dist), Tamil Nadu - 638183, IN
2 Department of Pharmacology, JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal (Dist), Tamil Nadu - 638183, IN
3 Department of Pharmaceutics, JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal (Dist), Tamil Nadu - 638183, IN

Abstract

Background: Studies of antioxidant substances in foods and natural products have gained increasing interest. The prevalence of neurodegenerative diseases are increasing globally. Effective treatment is necessary to minimize the neuronal damage and oxidative stress. Traditional medicines offer potent pharmacological activity with minimal side effects compared to synthetic drugs to treat such chronic disorders. Objective: The present study was aimed to evaluate the neuroprotective effect of ethanol extract of Pedalium murex Linn. (EEPM) leaves against lipopolysaccharide (LPS)-induced endotoxemia. Materials and Methods: Neurodegeneration was induced in rats with a single intraperitoneal injection of LPS (1 mg/kg). The neuroprotective activity was investigated following LPS-induced endotoxemia and then subjecting the animals to a battery of behavioural tests such as open field test (OFT), elevated plus-maze (EPM) and forced swim test (FST) to test anxiety and depression. At the end of the study, rats were sacrificed, brain hippocampal region was isolated and biochemical parameters were analysed. Results: These results highlight the neuroprotective potential of EEPM in LPS-induced anxiety and depressive illness model which may be partially due to inhibition of oxidative stress-neuroinflammatory cascade. Conclusion: The present study proved that EEPM has promising anti-anxiety, antidepressant action and can be potential candidates for the management of LPS-induced neurodegeneration.

Keywords

Anxiety, Depression, Lipopolysaccharide, Oxidative Stress, Neuroprotection.

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