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M. Sreejith ¹, N. Kannappan ², A. Santhiagu ³, P. M. Ajith ⁴

Affiliations
1 Department of Pharmaceutical Chemistry, National College of Pharmacy, Calicut, Kerala, IN
2 Department of Pharmacy, Annamalai University, Annamalai Nagar 608002, Tamil Nadu, IN
3 Department of Biotechnology, National Institute of Technology, Calicut, Kerala, IN
4 Department of Pharmacology, National College of Pharmacy, Calicut, Kerala, IN

Abstract

Aim: To investigate the possible anti-inflammatory and analgesic effects of the crude methanol (MEF) and ethyl acetate (EAEF) extracts of the aerial parts of Flacourtia sepiaria Roxb belonging to the family Flacourtiaceae.

Methods: Anti-inflammatory property of the MEF and EAEF extracts was tested by carrageenan induced acute paw edema in rats. For evaluating analgesic effects, acetic acid induced writhing test in mice and tail immersion tests in rats were conducted. The in vitro cyclooxygenase (COX) inhibitory activity was also conducted using COX inhibitory assay kit. Result: Both MEF and EAEF of Flacourtia sepiaria were found to have in vitro and in vivo anti-inflammatory effects. The most potent drug was found as diclofenac sodium (67%) in 6 h measurement, while MEF (65%) and EAEF (55.17%) of Flacourtia sepiaria in 400 mg/kg dose were found to have significant ability to reduce inflammation, with respect to control values. The extracts MEF and EAEF showed selective inhibitory activities against in vitro cyclooxygenases (COXs) inhibition assay. The MEF and EAEF decreased the acetic acid induced abdominal contraction and also significantly increased the reaction time of tail immersion test. These results showed that the plant extracts had both central and peripheral analgesic action. Conclusion: Thus the MEF and EAEF extracts of the aerial parts of Flacourtia sepiaria has significant antiinflammatory and analgesic activities.

Keywords

Anti-Inflammatory, Analgesic, Flacourtia sepiaria, Cyclooxygenase.

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V. Harikrishnan ¹, M. Sreejith ², M. J. Elthose ¹, Akash Marathakam ³

Affiliations
1 Mookamabika College of Pharmaceutical Science and Research, Muvatupuzha, Kerala, IN
2 Nazareth College of Pharmacy, Thiruvalla, Kerala, IN
3 National College of Pharmacy Kozhikode, Kozhikode, Kerala, IN

Abstract

Gelucire is the group of vehicle got from blends of mono-, di-and tri-glycerides with PEG esters of unsaturated fats. They have a wide assortment of utilization in pharmaceutical definitions. These are utilized as a part of the arrangement of quick release and maintained release of drug in sustained manner. Keeping in mind the end goal to build the bioavailability of medications, the residence time of the orally controlled dose frame in the upper GIT should be drawn out. The principle ways to deal with drawing out the gastric residence time of pharmaceutical dosage form incorporates thickness control conveyance framework, which drift on gastric liquid and a resource for treat Diabetes sort II. Gastro retentive strong scattering could be accomplished of ineffectively solvent medication Glibenclamide with the assistance of polyethylene glycol and Gelucire 50/13. Then again managed discharge gastroretentive multiparticulates of metformin hydrochloride could be accomplished utilizing Gelucire 39/01 and 43/01 grades. Further both details can be investigated individual and also in mix for enhanced bioavailability by their pharmacokinetic and pharmacodynamic assessment in wistar rats.

Keywords

Gelucire, Metformin, Glibenclamide, Solid Dispersion.

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