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C. Radhika ¹, Venkatesham Akena ², J. Venkateshwar Rao ¹, M. Sarangapani ²

Affiliations
1 Talla Padmavathi College of Pharmacy, Orus, Warangal-506009, A.P, IN
2 University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009, A.P, IN

Abstract

Some new (Napthalen-1-yloxyl/2-yloxy)-acetic acid (2-oxo-1, 2-dihydro-indole-3-ylidene)-hydrazides (4 and 5) have been synthesized by condensing naphthyl-1-oxy/2-oxy acetic acid hydrazides with different isatins. Their chemical structures have been confirmed by IR, NMR, and Mass spectroscopy and by elemental analysis. Investigation of cytotoxic activity was done by MTT assay method using HeLa and MCF cell lines. The compounds with 6-Bromo substitution (4e, 5e) have shown the prominent cytotoxic activity among the synthesized compounds.

Keywords

Synthesis/Indoles/Cytotoxicity.

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M. Anil Kumar ¹, M. Krishna Reddy ¹, M. Sarangapani ²

Affiliations
1 Reproductive Physiology Unit, Department of Zoology, Kakatiya University, Warangal (A.P.), IN
2 University College of Pharmaceutical Sciences, Kakatiya University, Warangal (A.P.), IN

Abstract

The present study was carried out on the effect of novel heterocyclic compound on total proteins, free amino acids and total lipids contents in different tissues to understand the protein and lipid metabolisms and their role in male rats. The treatment with Ethyl 1-(2-oxoindolin-3-ylideneamino)-1,2,3,6-tetrahydro-4-methyl-2-oxo-6-phenyl pyrimidine-5-carboxylate compound at dose level of 50mg/kg body weight for 21 days did cause mild changes in proteins and lipid metabolism in reproductive and somatic tissues of treated rats. In order to assess the physiological changes in testis, brain, heart, kidney and liver of rats, estimation of total proteins, free amino acids and total lipids has been under taken. The result showed a mild decrease in total protein levels, but in contrast to the same treatment caused a mild increase in free amino acid and total lipid levels.

Keywords

Novel Heterocyclic Compound, Proteins and Lipid Metabolisms, Physiological Changes, Reproductive Tissue, Somatic Tissues.

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M. Anil Kumar ¹, M. Krishna Reddy ¹, , M. Sarangapani ²

Affiliations
1 Reproductive Physiology Unit, Kakatiya University, Warangal (A.P.), IN
2 Department of Pharmaceutical Sciences, Kakatiya University, Warangal (A.P.), IN

Abstract

The present study has been proposed to evaluate the antifertility activity of novel hetercyclic compound in male albino rats. The ethyl 1-(5-chloro-2-oxoindolin-3-ylideneamino)-1,2,3,6-tetrahydro-4-methyl-2-oxo-6-phenyl pyrimidine -5-carboxylate compound has been found to possess significant antifertility effect in rats. Intraperitonial treatment of this compound (3mg/kg b.wt/day) for 21 days did not cause any effect on body weight. The weights of testis, cauda epididymis, seminal vesicles and ventral prostate were reduced significantly. Sperm suspension was obtained from cauda epididymis to calculate the sperm count, sperm motility sperm abnormality and fertility rate. There was a significant decrease in sperm count, sperm motility, fertility rate and a significant increase in sperm abnormality. The histological picture of testis is almost normal but the number of sperms were decreased and clumping of sperms were observed in the epididymal lumen and epithelial lining also shows degenerative changes.

Keywords

Heterocyclic Compound, Gonadosomatic Index, Fertility, Cauda Epididymis.

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