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Kshirsagar, M. D.
- Evaluation Study of Sustained Release Ocular Insert of Brimonidine Tartrate and Timolol
Abstract Views :261 |
PDF Views:2
Authors
Affiliations
1 P. Wadhawani College of Pharmacy, Yeotmal, IN
1 P. Wadhawani College of Pharmacy, Yeotmal, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 4 (2016), Pagination: 231-236Abstract
The present work showed that incorporation of hydrophilic polymer into hydrophobic matrix system can be successfully done in order to model ocular inserts of Brimonidine Tartrate and Timolol providing promising controlled release delivery system. The control of IOP, systemic absorption and hence possible side effects using inserts was found to be better than conventional eye drops. Thus, on the basis of in-vivo anti-glaucoma activity, ocular safety test and stability studies, it can be concluded that this ocular insert can be a promising once-a-day controlled release formulation after due considerations of human in vivo studies.Keywords
Brimonidine Tartrate, Timolol, Hydrophilic Polymer, Hydrophilic Polymer, Controlled Release Delivery System, Anti-Glaucoma Activity, Ocular Safety Test, Stability Studies.- Evaluation Study of Nasal Drug Delivery System Using Spray Drying Technique
Abstract Views :230 |
PDF Views:0
Authors
Affiliations
1 P. Wadhawani College of Pharmacy, Yeotmal, IN
1 P. Wadhawani College of Pharmacy, Yeotmal, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 7, No 2 (2016), Pagination: 67-69Abstract
In the present research work it has been studied the various evaluation parameters for the nasal drug delivery system using spray drying technique. The bulk density was mainly influenced by the solid fraction of the dispersion prepared prior to freeze-drying. The bulk density of the powder formulations had no influence on the nasal bioavailability of insulin in rabbits. From this study, it was concluded that the procedure for preparation of the nasal powder formulations was a robust production method. In the present study it has been demonstrated that the selection of an appropriate delivery system is a critical issue in the development of nasal powder formulations.Keywords
Nasal Powder Formulations, Bulk Density, Freeze-Drying, Spray Drying Technique.- Simultaneous RP-HPLC Determination of Drotaverine Hydrochloride and Mefenamic Acid in their Combined Tablet Dosage Form
Abstract Views :168 |
PDF Views:1
Authors
Affiliations
1 P. Wadhwani College of Pharmacy, Yavatmal-445001 (M.S.), IN
1 P. Wadhwani College of Pharmacy, Yavatmal-445001 (M.S.), IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 4 (2010), Pagination: 986-989Abstract
A simple, precise, accurate, rapid and reproducible reverse phase high performance liquid chromatographic procedure was developed for simultaneous determination of Drotaverine HCL and Mefenamic Acid in tablet dosage form at a single wavelength. The mobile phase used was a combination of Methanol:Acetonitrile:KH2PO4 Buffer (10 mM):(40:40:20) pH 3.5. The detection of the combined dosage form was carried out at 240 nm and flow rate was set to 1ml/min. Linearity was obtained in the concentration range of 3 to 30 μg/ml of Drotaverine HCL and 6 to 33 μg/ml of Mefenamic Acid with correlation coefficients of 0.9998 and 0.9999, respectively. The results of the analysis were validated statistically and recovery studies confirmed the accuracy of the proposed method.Keywords
Drotaverine HCL, Mefenamic Acid, RP-HPLC, Simultaneous Estimation.- Design and Characterization of Solid Lipid Nanoparticle Based Transdermal Drug Delivery System
Abstract Views :265 |
PDF Views:7
Authors
Affiliations
1 P. Wadhwani College of Pharmacy, Yavatmal (M. S.), IN
1 P. Wadhwani College of Pharmacy, Yavatmal (M. S.), IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 7, No 2 (2017), Pagination: 87-91Abstract
Transdermal drug delivery system (TDDS) is the dosage forms which deliver a therapeutically effective amount of drug across a patient's skin. The Solid lipid nanoparticles were successfully developed for rasagiline mesylate. SLN dispersions were prepared by melt emulsification and solidification at low temperature method. Physicochemical characterization including particle size, particle size distribution, Zeta potential, scanning electron microscopy, crystallinity study by DSC were carried out. In the Transdermal Drug Delivery System, Formulations F1-F9 was prepared by solvent casting method using 1.5%, 2.5% and 3.5% of HPMC K4M and 20%, 30% and 40% (w/w of dry polymer) of PEG 400. The formulation F5 was selected as the promising formulation on the basis of tensile strength, % elongation, and % drug content. Further, the patch was found to be free of skin irritation. From the results stability study it can be concluded that the patches can be stored at 40°C and 75% RH without any significant stability problems. The formulation satisfied all the pharmaceutical parameters of transdermal films and appears to be promising.Keywords
Transdermal Drug Delivery System, Solid Lipid Nanoparticles, Rasagiline Mesylate, Physicochemical Characterization, Solvent Casting Method.- Compatibility Study In-Vitro Drug Release Study of Solid Lipid Nanoparticle Based Transdermal Drug Delivery System for Rasagiline Mesylate
Abstract Views :241 |
PDF Views:8
Authors
Affiliations
1 P. Wadhwani College of Pharmacy, Yavatmal (M. S.), IN
1 P. Wadhwani College of Pharmacy, Yavatmal (M. S.), IN