Informatics Publishing Limited

N. M. Bhopale ¹, H. S. Sawarkar ², M. B. Narkhede ², N. V. Thorat ², M. R. Bhise ², S. S. Khadabadi ³

Affiliations
1 IBSS College of Pharmacy, Nimbari Phata, Buldana Road, Malkapur, Dist- Buldana-443 101, IN
2 I.B.S.S. College of Pharmacy, Malkapur- 443 101 (M.S.), IN
3 Govt. College of Pharmacy, Amravati-444 603 (M.S.), IN

Abstract

The purpose of the present investigation was to develop the sustain release matrix tablet of Tinospora cordifolia using the various polymers like HPMC (Hydroxy-Propyl-methyl-cellulose), Ethyl cellulose (EC), of different viscosity grade. Ethanolic extract of Tinospora cordifolia was used for the formulation of sustain release matrix tablet and tablet formulations were developed by using wet granulation method. Different diluents like lactose, magnesium stearate and cab-o-sil were used for improving flowability and compressibility. Binder such as polyvinyl pyrrolidone was used for optimization of the formulations. Sodium starch glycolate was used as disintegrating agent. Pre and post formulation parameters were studied for all the batches. HPMC –KM4 shows better result for matrix tablet in terms of sustain drug release with comparison to different viscosity grade of HPMC and ethyl cellulose. The dissolution study of the Tinospora cordifolia tablets exhibited 99.54% release of total polyphenol.

Keywords

Ethanolic Extract of Tinospora Cordifolia, HPMC, Ethyl Cellulose, Matrix Tablet.

Full Text

     

M. B. Narkhede ¹, P. V. Ajmire ², A. E. Wagh ², M. R. Bhise ², G. D. Mehetre ², H. J. Patil ²

Affiliations
1 Indira Bhuuddeshiya Shikshan Shantha’s College of Pharmacy, Buldana Road, Malkapur, Dist Buldana-443101, IN
2 Indira Bhuuddeshiya Shikshan Shantha’s College of Pharmacy, Malkapur, IN

Abstract

Vetiveria zizanioides belonging to the family Gramineae, is widely used as a traditional plant as refrigerant that cools and calms the entire body. The current study was focused to evaluate the antipyretic (yeast-induced pyrexia in albino rats) potential of the hexane extract (HEVZ) and methanol extract (MEVZ) of Vetiveria zizanioides ischolar_main. The yeast-induced pyrexia method was standardized by subcutaneous injection of yeast suspension (10 ml/kg body wt.) which increased rectal temperature after 17 hours followed by recording of rectal temperature at regular interval. Both extract at 75mg, 150mg and 300mg/kg dose significantly (P<0.05) reduced yeast-induced elevated temperature. Also the effect of extracts on normal body temperature was evaluated. Rectal temperature of rodents was recorded at a time interval of 1hrs, 2hrs, 3hrs, 4hrs and 5hrs after drug administration. Reduction is in a dose dependent manner.The anti-pyretic effect of HEVZ and MEVZ was comparable to that of a standard antipyretic agent paracetamol (150 mg/kg body wt, p.o).

Keywords

Antipyretic Activity, Vetiveria zizanioides, Yeast-Induced Pyrexia.

Full Text