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Manish, Kumar
- Comparative Study of Response on Fever, Regression of Spleen and Liver Size by Treatment with I.v. Amphotericin B and Oral Miltefosine in Cases of Visceral Leishmaniasis
Authors
1 Department of Pharmacology, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna, Bihar, IN
2 Department of Pharmacology, Patna Medical College, Patna, Bihar, IN
3 Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna, Bihar, IN
4 Department of Biochemistry, Saraswati Institute of Medical Sciences, Hapur, UP, IN
Source
International Journal of Contemporary Medicine, Vol 2, No 1 (2014), Pagination: 117-121Abstract
This study was designed to compare the clinical cure produced by two most commonly used drugs i.v. Amphotericin B and oral Miltefosine in cases of visceral leishmaniasis. It was an observational and cross-sectional study. This study was conducted on two groups A and B, each had fifty patients and given I.V. Amphotericin B and oral Miltefosine respectively. 100% of cases became afebrile by 12th day in group A while by 14th day in group B. Reduction in mean size of spleen was significant (p<0.01) at 15th day in group A patients while by 22nd day (p<0.05) in group B. 100% of cases had non palpable spleen after 22nd day till the end of 6th month in group A but remained palpable till 6th month in 4 cases in group B. Reduction in mean size of liver was significant (p<0.05) on 15th day in group A while 22nd day (p<0.05) in group B patients. Liver was not palpable after 22nd day of treatment in group A while in group B it was not palpable after 2nd month. These results suggest that the clinical cure achieved in terms of response on fever and rate of spleen and liver regression in group A patients were more faster than group B patients.Keywords
I.V. Amphotericin B, Oral Miltefosine, Response on Fever, Regression of Spleen and Liver Size- Comparative Study of Hepatic and Renal Markers in Treatment of Kala-azar with I.V. Amphotericin B and Oral Miltefosine
Authors
1 Department of Pharmacology, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna, Bihar, IN
2 Department of Pharmacology, Patna Medical College, Patna, Bihar, IN
3 Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna, Bihar, IN
Source
International Journal of Contemporary Medicine, Vol 2, No 1 (2014), Pagination: 206-210Abstract
This study was designed to compare the hepatic and renal markers in treatment with two most commonly used drugs I.V. Amphotericin B and oral Miltefosine in diagnosed cases of KALA-AZAR. This was an 'OBSERVATIONAL' and 'CROSS-SECTIONAL' study. This study was conducted on two groups each had fifty patients. I.V. Amphotericin B and oral Miltefosine were given to group A and B respectively. Rise of serum bilirubin was not significant (p>0.05) in either group. Mean SGPT and SGOT level were more in group B than that of group A. But the rise in mean SGPT and SGOT level was not statistically significant (p>0.05). Rise in BUN was significant (p<0.01) by the 15th day in Group A patients but it did not cross the normal limit. There was not significant (p 0.05) rise in the mean serum creatinine level during treatment in patients of both groups.
Fall in serum Potassium level was significant (p<0.05) at 22nd and 30th day of treatment in group A patients while the fall was not significant (p>0.05) in group B patients. These results suggest that during treatment hepatic and renal markers were not altered significantly which warrant the withdrawal of the drug in both groups. It is highly recommended that serial monitoring of hepatic and renal markers are useful parameters in anti kala-azar therapy.