Informatics Publishing Limited

P. N. Sudha ¹, D. Manley Backyavathy ², K. Sudhakar ³

Affiliations
1 Department of Chemistry, D. K. M. College for Women, Vellore-632 001, T.N., IN
2 Department of Zoology, Voorhees College, Vellore-632 001, T.N., IN
3 Department of Biological Sciences, Chezhian College of Education, Polur-606 803, T.N., IN

Abstract

Malathion, a pesticide in the organophosphate chemical family is the most commonly used pesticide in our country. Symptoms of exposure to malathion include headache, nausea, vomiting, burning in eyes, difficulty in breathing and lethargy. Earthworms have been used as biomarkers for assessing chemical environmental pollution. Due to their low cost, easy handling, their direct body contact with the soil and ethical issues related to mammalian studies, earthworms were chosen for the present study. Three doses of malathion 150, 300 and 600 mg/kg soil were used as treated soil. The effect of application of malathion on the earthworm Lampito mauritii was studied for 5, 10, 15 and 30 days exposure by evaluating the body weight, number of cocoons laid and the hatching efficiency of the cocoons. The results showed that there is a direct dose response relationship with respect to both, the concentration and time of application of malathion. The results have been statistically analysed.

Keywords

Pesticides, Melathion, Earthworm, Lampito mauritii, Non-Target Organism, Cocoons, Biomarkers.

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N. CH. Ramya Krishna Priya ¹, K. Sudhakar ², M. Chinna Eswaraiah ¹, M. M. Eswarudu ³, K. Prasanna Kumar ³

Affiliations
1 Department of Pharmacognosy, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda (Dt), Andhra Pradesh-508206, IN
2 Department of Pharmacognosy, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda (Dt), Andhra Pradesh -508206, IN
3 Department of Pharmaceutical Analysis, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda (Dt), Andhra Pradesh-.508206, IN

Abstract

Herbal medicine is the oldest form of health care known to mankind and it will not be an exaggeration to say that use of herbal drug for human health care is probably as ancient as mankind. Prosopis is a genus of flowering plants in the pea family, Fabaceae. The plant is also known as Algarrobo. The plant is found in the arid and semi-arid regions with ground water of between 3 and 10 m below the surface. It contains apigenin 8-glucoside, apigenin 6-glucoside, quercitin 3-glucoside, quercitin 3-rhamnoside, quercitin 3-rutinoside, and traces of myricetin 3-rhamnoside, luteolin, kaempferol-3-OMe quercetin, and quercitin 3-OMe. This plant is used for shade, timber, fuel, and concentrated forage for food, High protein content of the seeds suggests that they may be useful as protein supplement to poor grass. The pods are used as food. It is a good source of nectar and pollen.The bark exudes an amber-colored translucent gum used in mucilage and an ingredient in medicine. Water infused with the mesquite leaves can be used as eye drops. A ten percent infusion of the leaves shows some antibiotic activity.

Keywords

Prosopis chilensis, Algarrobo, Fabaceae, Apigenin 8-Glucoside , Nectar And Pollen.

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M. Shankar ¹, N. L. Gowrishankar ¹, S. Narendiran ¹, K. Sudhakar ¹

Affiliations
1 Department of Pharmaceutical Chemistry, Swami Vivekanandha Institute of Pharmaceutical Sciences, Vangapally (V), Yadhagirigutta (M), Nalgonda (District), Pin - 508286, Andhra Pradesh, IN

Abstract

The protein-ligand interaction plays a significant role in the structural based drug designing. In our research work we have taken the cyclo-oxygenase receptor (COX). The receptor was docked to the commercially available NSAID (Non Steroid Anti Inflammatory Drugs) Celecoxib and Naproxen Protein Structure Modeling Method, using INSIGHTII software. We tried to improve the binding efficiency and steric compatibility of Celecoxib and Naproxen against COX receptor. Several modifications were made to the probable functional groups which were interacting with receptor molecule. Analogs of the drug molecule were prepared using MODELLER9v1chemsketch and docked using INSIGHT II docking software. The modified drugs was sketched using chemsketch were found to be better than the convectional drugs available. Further from this work we can improve the steric compatibility and then Absorption, Distribution, Metabolism and Excretion (ADME) properties of the analogs can be analyzed using Insilco ADME tools.

Keywords

Insight II, Modeller 9V1, Savs, Rampage, Patchdock, Rasmol.

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Tribhuvan Singh ¹, Harvinder Singh Saini ², S. V. Ranganayakulu ², S. Ravi ³, K. Sudhakar ³

Affiliations
1 Guru Nanak Institutions Technical Campus - School of Pharmacy Ibrahimpatnam, Telangana - 501506, IN
2 Guru Nanak Institutions Technical Campus - School of Engineering and Technology Ibrahimpatnam, Telangana - 501506, IN
3 Rural Development Society, R&D Center, Punjagutta, Hyderabad - 500082, Andhra Pradesh, IN

Abstract

Objectives: To isolate Azadirachtin-A, from Seeds of Azadirachta indica and to perform molecular docking studies for antiproliferative activity against cervical cancer. Methods: The Current studies on Azadirachtin-A, a potent cervical anticancer agent, was designed for the isolation of Azadirachtin-A, from neem fruits collected from local area (Ibrahimpatnam), the seeds were first separated, dried and made in to coarse powder. The seed kernels was defatted and extracted with methanol using soxhlet apparatus. Methanolic extract of seeds were subjected to direct reverse phase High Performance Liquid Chromatography (HPLC) for separation of Azadirachtin-A, by molecular docking of Azadirachtin-A, using Molecular Operating Environment (MOE) 2008 software Findings: This revealed that Azadirachtin-A, has an affinity of 59.2% and 72% towards amino acids like Glycine 131 and Lysine 89 with polar intractions. Azadirachtin-A, found to interact with Cyclin E, was retrieved from the Protein Data Bank (PDB code: 1W98). The Azadirachtin-A, showed excellent, Increase Life Span (63.44 and 82.56), reduced the viable cells (30.4 ± 1.5 and 24.5 ± 1.6), and tumor volume (1.2 ± 0.05 and 1.0 ± 0.05) when compared to standard drug 5-Fluorouracil. Application: Azadirachtin-A, showed significant docking interaction with Cyclin E, active site using windows 2002, MOE 2008 software. Result showed that Azadirachtin-A, may lead to potent cervical anticancer agent.

Keywords

Azadirachtin-A, Azadirachta indica, Cervical Cancer, 5-Fluorouracil, (HeLa) Henrietta Lacks Cell Line, Molecular Docking.

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M. Naveena ¹, A. Naveen Kumar ¹, T. V. Manjunath ¹, K. Sudhakar ¹

Affiliations
1 Mechanical Engineering, Cambridge Institute of Technology, Karnataka, Bengaluru, IN

Abstract

Skid frame is a structural assembly consisting of beams of various cross sections and dimensions. This frame is to designed for flow control pumping station which is used to regulate the flow & pressure for fluids. The base frame is subjected to the gravitational loading of all components mounted viz. pump with motor, duplex strainer, control valves, instruments & piping etc. The flow control application mainly required for process industries like cement plants, power plants etc. This frame is designed with conventional CAD design Practice and the analyzed statically with FEA software. All the design standards are based on IS standards.

Keywords

Pumping Station, Skid Frame, Static Analysis.

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K. Sudhakar ¹

Affiliations
1 CSE Dept, G. Pulla Reddy Engineering College, Kurnool, IN

Abstract

Users store vast amounts of sensitive data on a big data platform. Sharing sensitive data will help enterprises reduce the cost of providing users with personalized services and provide value-added data services. However, secure data sharing is problematic. This paper proposes a framework for secure sensitive data sharing on a big data platform, including secure data delivery, storage, big data sharing platform. We present a proxy re-encryption algorithm based on heterogeneous ciphertext transformation The framework protects the security of users' sensitive data effectively and shares these data safely.

Keywords

Secure Sharing, Sensitive Data, Big Data, Proxy Re-Encryption.

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V. Baranidharan ¹, Kiruthiga Varadharajan ², K. Sudhakar ¹, N. V. Lokesh ¹

Affiliations
1 Department of Electronics and Communication Engineering, Bannari Amman Institute of Technology, IN
2 Department of Computer and Information Sciences, Annamalai University, IN

Abstract

License plate detection and recognition is the one of the major aspects of applying the image processing techniques towards intelligent transport systems. Detecting the exact location of the license plate from the vehicle image at very high speed is the one of the most crucial step for vehicle plate detection systems. This paper proposes an algorithm to detect license plate region and edge processing both vertically and horizontally to improve the performance of the systems for high speed applications. Throughout the detection and recognition the original images are detected, filtered both vertically and horizontally, and threshold based on bounding box method. The whole system was tested on more than twenty five cars with various license plates in Indian style at different weather conditions. The overall accuracy rate of success recognition is 93% at sunlight conditions, 72% at cloudy, 71% at shaded weather conditions.

Keywords

Plate Detection, Recognition, Segmentation, Noise Removal, Sobel Detector, Bounding Box.

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