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K. L. Bairy , K. Roopa , S. Malini , C. M. Rao

Abstract

Objectives: To study the possible antiulcer effects of alcoholic extract of Tinospora cordifolia in different animal models of ulcers. Methods and materials : The alcoholic extract of the whole plant was prepared and tested for antiulcer activity at the dose of 400 mg/Kg PO in pyloric ligation, ibuprofen and cold restraint induced gastric ulcer models. The effect of the extract was compared with famotidine (3.6mg Kg PO). Besides, the effect was also compared with misoprostal (7.2 μg/kg PO) in case of ibuprofen induced ulcer model. The antiulcer effects of the drugs were assessed on the parameters such as number, size and index of ulcers and the volume, acidity, and pH of gastric juice. Result: The extract of Tinospora cordifolia, famotidine and misoprostol significantly (p<0.05) reduced ulcer index in the models employed. While the antiulcer effect of the extract was comparable to that of the standard drugs in ibuprofen and stress induced ulcer models, its effect was significantly (p<0.05) lesser than that of famotidine in pyloric ligation method. Conclusion: Tinospora cordifolia possesses gastric ulcer protective principles.

Keywords

Tinospora cordifolia, Gastric Ulcer, Famotidine, Antiulcer

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K. L. Bairy

Abstract

Wounds are perhaps, inescapable events in the life of an organism and at times they are dangerous or even life threatening. In the management of wound, control of pain, bleeding and infection have received due attention and have been successfully dealt with. These achievements, together with astounding advances in the surgical skill, and techniques, have greatly improved the asthetics of wound scar. Yet there is a ring of truth in what has been recently emphasized "the scope of surgery over the centuries has been directly proportional to the degree to which we have been able to depend upon repair and resistance to infection. Extensive screening of plants for wound healing profile has shown some good results. These plant products affect various phases (coagulation,inflammation, fibroplasia, collagenation, epithelization and wound contraction) of healing alike or differently. This is possible because various phases of wound healing are apparently independent, but interlinked and run concurrently. Some plant products are already in use. Isolation of active principles of these plants may provide the basic nucleus upon which synthetic drugs can be produced. The selected and careful use of these plant products may definitely help in better wound management. Hence it is possible that, herbal remedies definitely hold hope for the discovery of potent prohealers.

Keywords

Wound Healing, Plant Products, Aloe vera, Lantana camara, Hypericum spp

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K. L. Bairy , A. Sharma , Adiga Shalini

Abstract

Objective: To study the effect of Syzygium malaccense on serum glucose, lipid profile and liver glycogen content in both normal and hyperglycemic rats. Methods: The aqueous and alcoholic extracts were compared with glibenclamide for their influence on fasting blood sugar, lipid profile and liver glycogen in both normoglycemic and to streptozotocin induced (50mg/kg ip) hyperglycemic rats. Results: In normoglycemic rats the aqueous and alcoholic extracts produced hypoglycemia but did not affect the lipid profile and liver glycogen content even on chronic treatment. In the hyperglycemic rats on chronic treatment both the extracts caused reduction in FBS and significantly reversed the diabetes induced hyperlipidemia and liver glycogen depletion. The alcoholic extract was found to be more active than aqueous and equivalent to that of glibenclamide. Conclusion: The extracts of Syzygium malaccense with their beneficial effects on blood sugar and hyperlipidemia associated with diabetes could serve as good adjuvant to other oral hypoglycemic agents.

Keywords

Syzygium malaccense, Hypoglycemic Activity, Lipid Profile

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K. L. Bairy , S. B. Ganesh , M. S. Adiga , A. Shalini

Abstract

Objective: To evaluate whether the extract of Ginkgo biloba (GB) could reverse the healing suppressant effect of Cyclophosphamide(CLP). Methods: The wound healing effects of CLP (12.6 mg/kg/ IP single dose on 3'd post wounding day) and GB (50 mg/kg IP) daily were tested on dead space and excision wound models in male rats. Results: CLP has significantly (p<0.05) reduced and GB has significantly(p<0.05) increased the breaking strength and hydroxyproline content of granulation tissue in dead space wounds. GB has significantly (p<0.01) reversed the suppressant effect of CLP. In case of excision wounds there was no change in wound contraction and epithelization period by CLP, GB or GB+CLP when compared to control. Conclusion: The healing suppressant effect of CLP was reversed by co-administration of GB. This effect of GB may due to its antioxidant property.

Keywords

Dead Space Wounds, Excision Wounds, Granulation Tissue, Hydroxyproline

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K. L. Bairy , C. M. Rao

Abstract

Objective: To evaluate the effects of Ginkgo biloba on wound healing. Materials and methods: The wound healing effects of dried extract of Ginkgo Biloba (GB) were tested at a dose of 50 mg/kg on dead space and excision wound models in male rats. Results: GB has significantly (p< 0.01) promoted the breaking strength and hydroxyproline content of granulation tissue in dead space wounds. In case of excision wounds while it did not affect the wound contraction, the epithelization period was significantly (p<0.01) shortened. Conclusion: GB exhibits a significant pro-healing activity, possibly by influencing the collagenation phase of wound healing.

Keywords

Ginkgo Biloba, Wound Healing, Dead Space Wound, Excision Wound, Granulation Tissue, Hydroxyproline

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Elsa Sanatombi Devi ¹, Shreemathi S. Mayya ², K. L. Bairy , Manu Mohan , A. Anjali , M. Aswathy , J. Jophy , S. Luan , M. Manu , J. Neethu , M. V. Shalabha , N. M. Shiyad , N. Vikas

Affiliations
1 Manipal University, Manipal, Karnataka, IN
2 Deptt. of Statistics, Manipal University, Manipal, IN

Abstract

A nurse who graduates from the student period is the one who is going to turn out to be a clinical nurse specialist, working in any setup to handle emergencies. But how far does the curriculum focuses on the very basic critical care to handle emergencies. It is well known fact that sudden cardiac arrest is the leading cause of death in the world and most of them die before reaching the hospital or in the emergency room. During such situations where time plays a crucial role in the recovery, even a second delay can further decline the chances of recovery. Hence is imperative to note, whether the student nurses are really competent to handle cardiac emergencies? The current scenario shows that nurses constitute the largest single group of health care professionals in any health care organization. The very nature of their work brings them closest to the population they serve. Due to their person to person interaction, Nurses are expected to be mainly responsible for the efficient and effective management of patient care services. More importantly, it must be ensured that they are adequately trained in terms of cardiac emergency drug management which is a crucial step in a patient's survival in cardiac emergencies. The present study emphasized on the existing knowledge and application skills on cardiac emergency drugs, which clearly showed that the students require further input into their knowledge and practice. Hence, errors in medications are made whether minor or major and even to the extent of losing a person's life. Therefore students' lack of complete knowledge and practice can have adverse impact on the quality of care and also threat to patient's life.

Keywords

Cardiac Emergency Drugs, Knowledge, Clinical Practice and Nursing Students.

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Elsa Sanatombi Devi Devi ¹, Ashok Rao ¹, S. Mayya ¹, K. L. Bairy ¹

Affiliations
1 MCON, Manipal University, Manipal, Karnataka, IN

Abstract

One of the greatest challenges to balancing work and home life is job demands. Job demands include time pressures and deadlines, long hours, unclear or conflicting duties, having too much responsibility, or work that is too tiring or boring. When employees are out of balance, they experience more stress and fatigue and tend to be absent from work more often due to these reasons. They have less focus while at work because they are worried about issues at home and they are also more distracted at home because work matters weigh on their minds. The end result is that neither the situation is healthy nor productive; in short, it's a lose/lose situation for employees, their families and their employer. Hence the researcher out of much curiosity conducted a descriptive survey to investigate the balance between work and life among the nursing and allied health personnel. The findings showed that majority, 65 (95.59%) has moderately balanced work-life and 2 (2.94 %) had well balanced work-life and only 1 (1.47%) had poor work-life balance and majority are satisfied with their job. The findings also showed that there was correlation between work-life balance and job satisfaction as obtained value was (.237) which is higher than the table value (.232) which indicates that higher the job satisfaction, better the work-life balance. Chi- Square test also revealed that there was no significant association between Work-life balance and the selected variables.

Keywords

Work Life Balance, Attitude, Perception, Nursing Personnel, Allied Health Personnel.

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Sanatombi Devi ¹, S. Mayya , K. L. Bairy , Anice George , Manu Mohan , Bobby Sindhu , Krishnaendhu , Aparna , Selma , Reshma , Sheila , D’souza , S. Melita , T. Latha

Affiliations
1 Department of Statistics Manipal University, Manipal Karnataka, IN

Abstract

A class of undergraduate nursing students of size 80 was randomized to control and experimental group for teaching pharmacology (respiratory drugs) using Active Lecture Cum Live Demonstration (ALLD) and Active Lecture Cum Video (ALV). The controls were taught with ALLD and the experimental groups of students were taught using ALV. It was observed that the mean post-test knowledge score (50.05) of the experimental group after the competency programme on drug administration using active lecture cum video were apparently higher than the control group (45). Hence the competency programme on drug administration using Active Lecture cum Video (ALV) proved to be more effective than Active Lecture cum Live Demonstration (ALLD).

Keywords

Drug Administration, MDI, Peak Flow Meter, Nebulization, Video, Active Lecture, Live Demonstration, Comparative Analysis, Medication Errors, Compliance, Pharmacology And Nursing Students.

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K. Manu Mohan ¹, Elsa Sanatombi Devi ², Aswini Kumar Mohapatra ³, Rahul Magazine ³, Chirag A. Bhandare ⁴, A. Yashoda ⁵, K. L. Bairy ⁶, Sreemathi S. Mayya ⁷

Affiliations
1 Department of Pulmonary Medicine, KMC, Manipal University, Manipal, IN
2 MCON, Manipal University, Manipal, IN
3 Pulmonary Medicine department, KMC, Manipal University, Manipal, IN
4 Pulmonary Medicine Department, KMC, Manipal University, Manipal, IN
5 KMC, Pulmonary Medicine Department Manipal University, Manipal, IN
6 Kasturba Hospital, Manipal University, Manipal, IN
7 Department of Pharmacology, KMC, Manipal University, Manipal, IN
8 Department of Statistics, Manipal University, Manipal, IN

Abstract

Out of the 115 health care professionals who were randomly selected, it was observed that most 95.7 % had been exposed directly or indirectly to fumigation. Majority 61 (53%) had been working in area for more than 5 years. Most 95.7% of these staff carried out fumigation as part of their responsibility in their respective unit. Majority, 60 (52.5%) had been exposed to fumigation more than 16 times and more. It was also noticed that majority, 60% of them had respiratory symptoms - cough was reported by 73.9 %, eye irritation 53%, nasal symptom 22.6%, wheezing 13.9%, Breathlessness 12.2 % and skin irritation 6.1%. Of these 60 % who had respiratory symptoms amazingly only 9.6% had reported to their physician for medical help. This clearly indicates that chemicals used for fumigation causes respiratory symptoms minor or major in nature. It is also noted that health problems are being neglected and not reported for early management or change.

Keywords

Nursing Personnel, Ot Technician, Fumigation, Respiratory Symptoms.

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Elsa Sanatombi Devi , Ravindra Prabhu ¹, P. P. Bhanumathi ², Leena Sequiera ³, Sreemathi S. Mayya ⁴, K. L. Bairy ⁵, K. Manu Mohan ⁶

Affiliations
1 Nephrology Department KMC,, IN
2 Nursing Consultant, Koyli college of Nursing Kannur, Kerala, IN
3 MCON, IN
4 Department of statistics, IN
5 Pharmacology department KMC, IN
6 KMC Manipal, IN

Abstract

Effective nursing care requires identification of the needs of the patient and planning nursing care according to patient's needs. In the Indian context it is very much necessary to study the nursing care needs of patients undergoing hemodialysis even though enough literatures on nursing care protocol based on the nursing care needs of patients are available in countries like U.S.A. Interview carried out among 50 patients on their health problems while undergoing Hemodialysis were ranked so that priority care can be provided. Following the priority problems, a nursing process approach was developed, which has been used by nurses working in the dialysis unit while taking care of the clients. The study found that the nursing process approach was very effective and proved rational care of patients undergoing Hemodialysis as it could prevent the complications.

Keywords

Hemodialysis, Physical And Psychological Problems, Nursing Personnel, And Nursing Process Approach.

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Mohanbabu Amberkar , Lalit Mohan , Meena Kumari , K. L. Bairy

Abstract

Introduction - Knowledge of pharmacolo gy to choose and prescribe drugs is a major challenge encountered by medical practitioners. A number of initiatives have been carried out to improve the teaching of pharmacology and applied therapeutics. Material & methods - A survey was conducted on medical students, pursuing pharmacology at Kasturba Medical College, Manipal, during the month of August 2010, to obtain information regarding students attitude towards Pharmacology . Result - Two hundred and fourteen students participated. The total median score was 56 ( maximum score 80). Majority of them suggested to have more problem based learning than didactic lectures and to have integrated teaching with other clinical subjects. Suggestions to improve pharmacology teaching were noted. Conclusion - The findings of the study would be of interest to medical educators in modifying undergraduate pharmacology teaching programme.

Keywords

Pharmacology, Problem - Solving, Student Attitude, Survey, Teaching.

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Chogtu Bharti , Adiga Sachidanand , Prabhu Mukyaprana , K. L. Bairy

Abstract

The efficacy and toxicity of four commonly used antimalarials was evaluated. The combinations evaluated were Artesunate and Doxycycline, Quinine and Doxycycline, Artesunate and Quinine, Artesunate and Mefloquine. The four combinations did not show any statistically significant difference in terms of days of defervescence, parasite clearance and hospital stay. All the four combinations were well tolerated.

Keywords

Antimalarials, Artesunate, Doxycycline, Quinine, Mefloquine.

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