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Authors
Affiliations
1 Department of Pharmacognosy, Venkateshwara Institute of Pharmaceutical Sciences, Charlapally, Nalgonda-508001, Andhra Pradesh, IN
2 GBN Institute of Pharmacy, Ghatkesar, RR District, Andhra Pradesh, IN
3 Sai Pranavi College of Pharmacy, Keesara, Ghatkesar, RR District, Andhra Pradesh, IN
4 Mother Theresa College of Pharmacy, NFC Nagar, Ghatkesar, RR District, Andhra Pradesh, IN
Source
Asian Journal of Pharmaceutical Research, Vol 1, No 3 (2011), Pagination: 69-71
Abstract
The present study was carried out to investigate the anti-inflammatory property of petroleum ether, alcoholic and aqueous extracts of Mimosa pudica Linn leaves using experimental animal models. The anti-inflammatory activity of the various extracts was studied based on their effects on carrageenan-induced paw oedema and cotton pellet granuloma in rats. The extracts in dose levels of 50,100 and 200 mg/kg orally were used for anti-inflammatory studies. The ethanol and aqueous extracts of leaves of Mimosa pudica Linn significant (P<0.05) anti-inflammatory activities in a dose-dependent manner to that of standard drug indomethacin, while petroleum ether extract exhibit minimum inhibitory effect in carageenan induced hind paw oedema and cotton pellet granuloma in rats. All the doses used when compared to the control group. The results obtained indicate that the crude leaf extracts of mimosa pudica possess potent anti-inflammatory by supporting the folkloric usage of the plant to treat various inflammatory conditions.
Keywords
Mimosa pudica, Anti-Inflammatory Activity, Rat Paw Oedema, Carrageenan Induced Inflammation.
