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Misra, Harsh
- A Study of Protective effect of Ginger (Zingiber Officinale) in Normal and Carbon-Tetrachloride Induced Hepatotoxic Rats in Western U.P. India
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Authors
Affiliations
1 Department of Medicine, Saraswathi Institute of Medical Sciences Hapur, U.P., IN
2 Department of Pharmacology, Saraswathi Institute of Medical Sciences Hapur, U.P., IN
3 Department of Biochemistry, Saraswathi Institute of Medical Sciences Hapur, U.P., IN
1 Department of Medicine, Saraswathi Institute of Medical Sciences Hapur, U.P., IN
2 Department of Pharmacology, Saraswathi Institute of Medical Sciences Hapur, U.P., IN
3 Department of Biochemistry, Saraswathi Institute of Medical Sciences Hapur, U.P., IN
Source
Indian Journal of Forensic Medicine & Toxicology, Vol 7, No 2 (2013), Pagination: 64-67Abstract
The current study has been conducted to investigate the affect of ginger on hepatic antioxidant enzymes system in carbon tetrachloride induced hepatotoxic rats. The first set of animals received only ginger-supplemented diet while the another set were treated with CCl4 before maintaining them on ginger-based diets.Consumption of the experimental diets by the normal rats produced significant elevation (p<0.05) in the activities of the hepatic aspartate aminotransferase and alanine aminotransferase as well as the concentration of protein and albumin. Administration of CCl4 to the second set of rats resulted in the alteration of the liver function parameters . However, the significantly reduced (p<0.05) marker enzymes such as AST, ALT, due to CCl4 treatment were restored towards normalization on consumption of ginger diet. The biochemical parameters like total protein and albumin were also restored towards normal levels. The findings indicate that the ginger is an efficient hepatoprotective and antioxidant agent against CCl4-induced liver toxicity.Keywords
Aminotransferases, Carbon tetrachloride (CCl4), De novo synthesis Hepatotoxicity, Spices
References
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- A Study of effect of Phenytoin on Liver Enzymes in Epileptic Patients in Western Uttar Pradesh
Abstract Views :487 |
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Authors
Affiliations
1 Department of Pharmacology, Saraswathi Institute of Medical Sciences Hapur, U.P., IN
2 Department of Biochemistry, Saraswathi Institute of Medical Sciences Hapur, U.P., IN
1 Department of Pharmacology, Saraswathi Institute of Medical Sciences Hapur, U.P., IN
2 Department of Biochemistry, Saraswathi Institute of Medical Sciences Hapur, U.P., IN
Source
International Journal of Contemporary Medicine, Vol 1, No 2 (2013), Pagination: 11-14Abstract
Aim & Objective: In this study, we investigated the effects of phenytoin on hepatic enzyme levels in epileptic patients.
Method: In this prospective clinical study, we measured the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT) on 120 epiteptic patients. consecutive admissions to our epilepsy unit.
Result: Serum gamma glutamyl transferase (gammaGT), AST, ALT activities have been estimated in 120 epileptic patients taking Phenytoin as anticonvulsant drugs. Serum AST, ALT & GGT levels were increased.
Conclusion: We found most of our patients on Phenytoin had an elevated serum concentration of GGT, which is consistent with previous reports. AST and ALT were also elevated in these patients and therefore suggested the increased GGT was due to enzyme induction. Elevation of GGT needs to be considered differently in light of the use of new antiepileptic medications.
Keywords
Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Gamma-glutamyl Transpeptidase (GGT), Metabolic Abnormalities, Phenytoin (PHT).References
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