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Gupta, Geeta
- Comparative Study of the Therapeutic Efficacy of the Dapsone (Alone), Dapsone Plus Tacrolimus (Topical) and Dapsone Plus Triamcinolone (Topical) in Oral Lichen Planus
Authors
1 Department of Dermatology, Santosh Medical College, Ghaziabad (UP), IN
2 Department of Microbiology, Santosh Medical College, Ghaziabad (UP), IN
Source
Indian Journal of Public Health Research & Development, Vol 4, No 1 (2013), Pagination: 83-86Abstract
Background: Oral lichen planus (OLP) is a common, chronic inflammatory condition, which frequently present with symptoms of pain and irritation. OLP is difficult to manage. Existing clinical trials have shown that oral Dapsone and topical corticosteroids are often effective in the management of OLP. However, Tacrolimus has recently been shown to be an effective treatment of OLP without any side effects.
Objective: The purpose of this study was to compare the efficacy and safety of Dapsone (alone), Dapsone + Tacrolimus (topical) and Dapsone +Triamcinolone (topical) in management of OLP. Material and Method: In this randomized comparative double-blind study, 57 patients with oral lesions consistent clinically and histologically with OLP were recruited. Patients were divided into three groups of 17 and 22 & 18. In group-1, 17 patients were given oral Dapsone alone. In group-2, 22 patients were given oral Dapsone and topical Tacrolimus (0.1%).while in group 3, 18 patients were given oral Dapsone with topical Triamcinolone acetonide (0.1%).
Results: Group 2 in which oral Dapsone and topical Tacrolimus (0.1%) given showed the best results i.e. good response shown by 45.45% patients and excellent response shown by 36.36% patients without any major side effects.
Conclusions: The study showed that Dapsone in combination with topical Tacrolimus ointment (0.1%) is safe, well tolerated, and effective therapy for OLP
Keywords
Dapsone, Oral Lichen Planus, Topical Therapy, Tacrolimus Ointment, Triamcinolone Acetonide
References
- Gorouhi F, Solhpour A, Beitoahi JM, Afshar S, Davari P, Hasheni P,Nassiri KM Firooz: A Randomized trial of pimecrolimus cream versus Triamcinolone acetonide paste in the treatment of oral Lichen Planus .J Am Acad .Dermatol 2007; 57(5)806.
- Albrecht M, Banoezy J. Occurrence of Oral Leukoplakia & Lichen Planus in Diabetes Mellitus. J Oral Pathol Med 1992, 21:364-66.
- Persiæ S, Mihie LL, Budimir J, Situm M, Bulatz V, Krolo I. Oral lesions in patients with lichen planus. Acta Clin Croat. 2008;47(2):9
- Philip Sugerman, Stephen R Porter, Oral LichenPlanus. http://emedicine.medscape.com/ article/1078327-overview,2009
- Eversole LR. Immunopathology of oral mucosal ulcerative, desquamative, and bullous diseases: selective review of the literature. Oral Surg Oral Med Oral Pathol 1994;77:555-71
- Glick M, Greenberg M. Burket’s Oral Medicine: Diagnosis and Treatment, 10th ed. Hamilton: BC Decker Inc; 2003:107-110
- Falk DK, Latour DL, King LE. Dapsone in the treatment of erosive lichen planus. J Am Acad Dermatol 1985;12:567
- Beck HI, Flemming B. Treatment of erosive lichen planus with dapsone. Acta Derm. Venereol (Stockh) 1986;366-367.
- Kumar B, Kaur I, Sharma VK. Efficacy of dapsone in lichen planus. Indian J Dermatol Venereol Leprol 1989;55:164-166.
- Kumar V, Garg BR, Baruah MC, et al. Childhood lichen planus. Dermatol 1993;20:175-177.
- Radfar L, Wild RC, Suresh L. A Comparative treatment study of topical tacrolimus and clobetasol in Oral Lichen Planus. Oral Surg Oral Med Oral path Oral Radiol Endod 2008;105(2),187-93.
- Byrd JA, Davis MD, Rogers RS .Response of Oral Lichen Planus to topical tacrolimus in 37 patients. J Arch Dermatol 2004;1: 508-12.
- Buajeeb W, Kraisapan P .Efficacy of topical retionoic acidcompared with topical fluocinolone acetonide in the treatmentof Oral Lichen Planus. Oral Surg, Oral Med Oral Pathol OralRadiol Endod 1997; 83,21-25.
- Rozycki TW, Rogers RS. Topical tacrolimus in the treatment of symptomatic oral lichen planus: a series of 13 patients. J Am Acad Dermatol 2002; 46:27-34.
- Morrison L, Gorman A. An open trial of topic tacrolimus for erosive lichen planus. J Am Acad Dermatol 2002; 47:617-620.
- Byrd JA, Davis MD, Rogers RS. Response of oral lichen planus to topical tocrolimus in 37 patients. J Arch Dermatol 2004;140:1508-12.
- Riano A, Martino R, glesias ME, Garatea J. Topical tacrolimus, alternative treatment for oral erosive lichen planus resistant to steroids. J Med Oral Patol Oral Cir Buccal 2006;11:462-6.
- Passeron T, Laccour JP, Fontas E, Ortonne JP. Treatment of oral erosive lichen planus with pimecrolimus cream. A double-blind, randomized prospective trial with measurement of pimecrolimus level in the blood. J Arch Dermatol 2007;143:472-6.
- Stendahl O, Mobin L, Dahlgren C. The inhibition of polymorphonuclear toxicity by dapsone. J Clin Invest 1998;62:214-220.
- Ruzicka T, Wasserman SI, Soter NA, et al. Inhibition of rat mast cell arachidonic acid cyclo-oxygenase by dapsone J Allergy Clin Immunol 1983;72: 365-370.
- Beigueltnan B, Pisani RCB. Effect of DDS on phytohae-magglutinin induced lymphocyte transformation. Int J Lepr 1974;42:412-415.
- Ruzicka T, Assmann T, Homey B. Tacrolimus: the drug for the turn of the millennium Arch Dermatol 1999;135:574-580.
- Cooper KD. Atopic Dermatitis: recent trends in pathogenesis and therapy. J Invest Dermatol 1994; 102:128-137.
- Nghiem P, Pearson G, Langley RG. Tacrolimus and pimecrolimus: From clever prokaryotes to inhibiting calcineurin and treating atopic dermatitis. J Am Acad Dermatol 2002; 46: 228-41.
- Pederson AK, Lausen B. Glucocorticosteroid therapy and oral medicine. J Oral Pathol Med 1984;13:1-15.
- Prevalence of Candidiasis, Trichomoniasis and Bacterial Vaginosis among Women of Reproductive Age Group
Authors
1 Department of Microbiology, Santosh Medical College and Hospital, Ghaziabad (UP)
2 Department of Microbiology, ESI-PGIMSR, ESI Hospital, New Delhi,India
3 Department of Obstetrics and Gynaecology, Santosh Medical College & Hospital, Ghaziabad (UP)
Source
Indian Journal of Public Health Research & Development, Vol 4, No 2 (2013), Pagination: 94-98Abstract
Background: Vaginal symptoms are leading reason for patients to visit gynecologist. Few data are available on prevalence of different causes of vaginitis.
Objective: To find out prevalence of Candidiasis, Trichomoniasis and bacterial Vaginosis among the women of reproductive age group.
Method: 400 sexually active married women attended gynecology OPD and ANC clinic at Santosh Hospital, Ghaziabad included in study. Participants were interviewed and structured questionnaire were filled. Two high vaginal swabs were collected from each woman. One swab was used for making smear and other used for culture on SDA. Candidiasis was detected by presence of curdy white discharge, Gram stain and culture on SDA. Trichomoniasis was detected by presence of green yellow frothy discharge, Wet mount and Papanicolaou stain. Bacterial Vaginosis was detected by presence of homogenous white or grey discharge, Amsel method and Gram stain.
Results: Over all prevalence of vaginitis was 47.75 %. The prevalence of Candidiasis was 54.5% by Gram stain and 21.5% by culture method. The prevalence of Trichomoniasis was 12% by Wet mount and 8.75% by Pap stain. The prevalence of bacterial Vaginosis was 24% by Amsel criteria and 29% by Gram stain.
Conclusions: This study raised an awareness regarding high vulnerability of women in reproductive age group for vaginitis. The study reveals that prevalence of candidiasis is 21.5%, trichomoniasis 8.75% and bacterial vaginosis 29% .
Keywords
Vaginitis, Prevalence, Candidiasis, Trichomoniasis, Bacterial Vaginosis, Reproductive Tract InfectionReferences
- Banel KM, Singh K, Bhatnagar S. Prevalence of lower RTIs among married females in the reproductive age groups (15-45 yrs) Health popula perspect issue 2001;24:157-163.
- Galask RP: vaginal Colonization by bacteria and yeast, American Journal of Obstetrics and Gynaecology:1988;158:993-995.
- Kenneth J, Ryan Ross S, Berkovitz Robert L, Barbieri, Kistner’s Gynaecology principles and practice: 1998; 6th edition:84-85.
- P. Bhalla, Rohit Cawla, S Garg, MM Singh. Prevalence of bacterial vaginosis among women in Delhi, India. Indian J. Med. Res. 2007;125:167- 172.
- Maitra Nandita, Gupta Monika, Kavishwar Abhay- Vaginal Discharge; Risk Assessment and predictive value of cytologic smear and culture: Journal Of obstetrics and Gynaecology, India.2008;58:511-517.
- N Maitra, M Gupta, KV Kavishwar. Clinical spectum and microbial etiology of reproductive tract infection in women attending a general gynaecology clinic: Int. J. Gynaecol. Obstet. India. 2007;10(4):25–29.
- Srivastava A, Nandan D, Mehrotra AK. Comparative study of perception about reproductive tract infections among married women in rural, urban and urban slum areas. Indian J. Community Med. 2004;29:67-8.
- Vineeta Gupta, Pratima Gupta, Biswaroop Chatterjee, Rani Bansal. Clinicomicrobiological profile of women with vaginal discharge. J. Indian Med. Assoc. 2009;103(3):164-6.
- Mohanty S, Xess I, Hason F et al- Prevalence and susceptibility to fluconazole of Candida species causing vulvovaginitis. Indian J. of Med. Res. 2007;126:216-219.
- Sobel JD, S Faro, RW Force, B Foxman. Vulvovaginal candidiasis: epidemiologic, diagnostic, and therapeutic considerations. Am. J. Obstet. Gynecol.1998;178:203-211.
- Sobel JD. Vulvovaginal candidiasis. In: Sexually Transmitted Diseases. Newyork. McGraw- Hill.1999;629-37.
- Jindal Neerja, Aggarwal Aruna, Gill Paramjeet, Significance of candida culture in women with vulvovaginal symptoms. J. Obstet. Gynecol. India 2006;56(2):139-141.
- Beal et al. The plastic envelop method, a simplified technique for culture diagnosis of Trichomoniasis. J. Clin. Microbiol.1992;30:2265– 2268.
- Sood S, Mohanty S, Kapil A, Tolosa J. In pouch TVTM culture for detection of Trichomonas vaginalis. Indian J. Med. Res.2007;125:567-71
- Krieger JN. Urologic aspects of Trichomoniasis. Invest. Urol.1981;18:411–7
- Rongpisuthipong A et al. Is the papanicolaou smear useful for diagnosing sexually transmitted diseases ? Obstet Gynecol;1987;69:820–4.
- Garg S, Sharma N, Bhalla P, Sahay R et al. Reproductive morbidity in an Indian urban slum: need for health action. Sex. Trans. Infect.2002;78:68-9.
- Sewankambo N, RH Gray, MJ Wawer, L Paxton et. al. HIV-1 infection associated with abnormal vaginal flora morphology and bacterial vaginosis. Lancet 1997;350:546-550.
- Schwebke JR, Hillier SL, Sobel JD et al. Validity of the vaginal gram stain for the diagnosis of bacterial vaginosis. Obstet. Gynecol.1996;88: 573-576.
- Clinico-mycological Evaluation of Dermatophytes and other Fungal Agents Isolated from Various Clinical Samples
Authors
1 Department of Microbiology, Santosh Medical College, Ghaziabad, (UP) India, IN
2 Department of Dermatology, Santosh Medical College, Ghaziabad, (UP), IN
3 Department of Community Medicine, Santosh Medical College, Ghaziabad UP, IN
Source
International Journal of Contemporary Medicine, Vol 2, No 1 (2014), Pagination: 17-20Abstract
Background: Human pathogenic dermatophytes are keratinophilic molds that infect human skin, nails and hairs. Three genera (Trichophyton, Micosporum and Epidermophyton) of these organisms exist: however, their preferred sites for infections vary. Current management often consists of the topical and systemic administration of antifungal agents or a combination of both. However, these approaches may not be successful in every case due to such factors as difficulty with long term application of topical medications. Despite the successful use of systemic medications side effects and drug resistance remains a major obstacle. The treatment of dermatophyte infections represents a significant cost burden.Aims and Objectives: To study the epidemiology, clinical types and mycological features of dermatophytes from various clinical samples from dermatology department, Santosh Hospital.
Material and Method: A total of 100 samples were collected including infected skin, hair and nail samples for a period of six months. Before collecting the samples, 70% alcohol was applied to the infected area and ensured that it was totally dried. Skin samples were collected by scraping, nail sample by clipping and hair samples collected by using sterile forcep or scalpel. Identification was done by KOH mount, culture on SDA, pigment production, lactophenol cotton blue staining and biochemical tests and slide culture techniques.
Results: Dermatophytosis was manifested clinically more in the age group 21 - 30 years age. Tinea corporis was the predominant clinical presentation followed by Tinea cruris. Tinea capitis was the predominant clinical presentation in children and Tinea manuum was the commonest clinical type found in female patients. In the present study the male to female ratio was found 1.5 : 1. Majority of patients were belonged to the low socio-economic status. Trichophyton rubrum was the predominant pathogen followed by the Trichophyton mentagrophytes.
Conclusion: Tinea corporis was found the most common clinical type of dermatophytosis and Trichophyton rubrum was found the most common fungal isolate in this part of Uttar Pradesh.