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Authors
Affiliations
1 Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam- 786004, IN
2 TVES’s College of Pharmacy, Nehru Vidyanagar, Faizpur, M.S-425503, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 4 (2011), Pagination: 591-596
Abstract
A new series of 7-(3-(benzo[d]thiazol-2-ylamino)propoxy)-4-methyl-2H-chromen-2-one derivatives(4a-4k) were synthesized and evaluated for their D2 and 5HT2 antagonistic activity as a measure of atypical antipsychotic property. Most of these compounds showed dopamine D2 receptor antagonistic activity from moderate to high potency along with serotonin 5-HT2 receptor blockage activity. The dopamine D2 and serotonin 5-HT2 receptor blockage activity was evaluated by inhibition of apomorphine-induced climbing behavior and 5HTP induced head twitches in mice respectively. Compounds 7-(3-(benzo[d]thiazol-2-ylamino)propoxy)-4-methyl-2H-chromen-2-one derivatives (4a-4k) were synthesized by addition of various 2-amino benzothiazoles substituted derivatives (3a-3k) with 7-(3- Chloropropoxy)-4-methyl-2H-chromen-2-one(2) refluxing in dry pyridine. The synthesized compounds were characterized with the help of spectral and analytical study.
Keywords
Schizophrenia, Atypical Antipsychotics, Benzothiazole, Chromen-2-One.
