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Chakravarthi, G.
- Evaluation of Anti-depressant Activity of Methanolic Seed Extract of Avena Sativa L. in Mice
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PDF Views:2
Authors
Affiliations
1 K.V.K College of Pharmacy, Affiliated to Jawaharlal Nehru Technological University, Hyderabad, IN
2 T.R.R College of Pharmacy, Affiliated to Jawaharlal Nehru Technological University, Hyderabad, IN
3 College of Pharmaceutical Sciences, Affiliated to Biju Patnaik University of Technology, Rourkela, IN
1 K.V.K College of Pharmacy, Affiliated to Jawaharlal Nehru Technological University, Hyderabad, IN
2 T.R.R College of Pharmacy, Affiliated to Jawaharlal Nehru Technological University, Hyderabad, IN
3 College of Pharmaceutical Sciences, Affiliated to Biju Patnaik University of Technology, Rourkela, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 4 (2013), Pagination: 212-217Abstract
The main objective of the study to evaluate the Anti-depressant activity of seeds extract of Avena sativa in Forced swim test (FST), Tail Suspension test (TST) and antagonism of Apomorphine induced hypothermia in mice. Phytochemical screening showed presence of carbohydrates, alkaloids, flavanoids, steroids, glycosides, saponins, amino acids, gums and mucilage. MSEAS did not produce any lethal effect even upto 2000mg/kg, p.o during Acute Oral Toxicity study. In FST and TST, MSEAS showed diminution of duration of immobility time in 100mg/kg but not in 200mg/kg. In antagonism of Apomorphine induced hypothermia model, Desipramine but not both doses of MSEAS significantly antagonised the Apomorphine induced hypothermia. From the above finding concluding that, shortening of immobility time in the FST and TST indicating, MSEAS showed antidepressant activity acting either by the enhancement of central 5-HT or catecholamine neurotransmission and Antagonism of Apomorphine induced Hypothermia indicating, MSEAS was not acting through Adrenergic system.Keywords
avena Sativa, Antidepressant Activity, Forced Swim Test, Tail Suspension Test, Antagonising Apomorphine Induced Hypothermia
References
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- Anti Anti-obesity and Antihyperlipidemic Activity of Ougeinia oojeinensis (Roxb.) in High Fat Diet-Induced Obesity in Experimental Animals
Abstract Views :157 |
PDF Views:76
Authors
K. Jagadeeshwar
1,
R. Subhakara Raju
1,
G. Chakravarthi
1,
A. Rajasekhar Reddy
2,
G. S. N. Koteswara Rao
2,
Narender Malothu
1
Affiliations
1 KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur – 522502, Andhra Pradesh, IN
2 Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, VL Mehta Road, Vile Parle (W), Mumbai - 400056, Maharashtra, IN
1 KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur – 522502, Andhra Pradesh, IN
2 Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, VL Mehta Road, Vile Parle (W), Mumbai - 400056, Maharashtra, IN
Source
Journal of Natural Remedies, Vol 23, No 2 (2023), Pagination: 545-554Abstract
The present study was planned to assess the anti-obesity efficacy of petroleum ether, ethyl acetate, and methanolic extracts of leaves of Ougeinia oojeinensis (Roxb.) belonging to the family Fabaceae. The soxhlation method was employed to produce the extracts. Wistar rats were subjected to a high-fat diet for 40 days to induce obesity. Along with the high-fat diet, a standard drug Orlistat 50 mg/kg and various extracts of O. oojeinensis at 100 mg/kg and 200 mg/kg were administered for 40 days. The key markers like lipid profiles, SGOT, SGPT, glucose, body weight, food intake, body temperature, atherogenic index, coronary index, and weight of the organs were assessed. The anti-antioxidant properties like TBARS, GSH, GR, Gpx, SOD, and CAT were also estimated. The results revealed that O. oojeinensis with the doses 100 and 200 mg/kg showed significant Anti obese and hypolipidemic effects in rats fed with a high-fat diet.Keywords
Antihyperlipidemic Anti-Obesity, Antioxidant, Lipid Profile, O. oojeinensis.Full Text
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