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Ibrahim, F.
- Derivative UV Spectrophotometric Analysis of some Pharmaceutically Important Halogenated 8-hdroxyquinoline Derivatives via their Pd (II)-complexes
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1 Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, 35516, EG
1 Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, 35516, EG
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Scientia Pharmaceutica, Vol 68, No 3 (2000), Pagination: 297-307Abstract
A derivative UV-spectrophotometric method was developed for the analysis of two halogenated 8-hydroxyquinoline derivatives; iodochlorohyroxyquin (I) (Clioquinol) and di-iodohydroxyquin (II) (iodoquinol). The proposed method depends on the formation of Pd II-ligand complexes in methanol-acetonitrile mixture, which exhibits an UV-spectra with an appreciable value of ε. Zero order (0D), first order (1D) and fourth order (4D) derivative measurements were applied for the quantitative analysis of the drugs. A linear correlation was established between absorbance and concentration for the 0D mode in the range 2-14 μg ml-1 and 2-18 μg ml-1 for (I) and (II) with average % recoveries of 99.83 ± 1.04 and 99.9 ± 10.64 respectively. Also a linear correlation was obtained between the trough of the peak and concentration for 1D mode in the range of 0.16-0.8 μgml-1 for both drugs with average % recoveries of 100.23 ± 1.04 and 100.18 ± 1.14 for (I) and (II) respectively. Besides, the 1D mode was successfully applied for the analysis of binary mixture containing both (II) and metronidazole (III) in tablet formulations. The average % recoveries were 99.42 ± 0.358 and 98.81 ± 0.973 for (II) and (III) respectively. In the 4D mode, a linear correlation was attained between the amplitude of the peak and concentration in the range 0.1-0.8 μg ml-1 for (I) and (II), with average % recoveries of 99.6 ± 0.84 and 100.06 ± 0.98. The limit of detection (LOD) was 2.1ng ml-1 and 2.3ng ml-1 for (I) and (II) respectively. The suggested method was successfully applied for accurate, sensitive and selective analysis of the studied drugs in bulk and single or combined dosage forms with average % recoveries of 99.74 ± 0.480-99.84 ± 0.515 and 99.44 ± 0.71-100.58 ± 1.06 for (1D) and (4D) respectively. The results obtained were favorably compared to those given by a reference method.Keywords
Derivative Spectrophotometry, Halogenated 8-hydroxyquinolines, Pd (II)-complexes, Clioquinol, Iodoquinol, Dosage Forms.
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- A Simple Kinetic Spectrophotometric Method for the Determination of Certain 4-Quinolones in Drug Formulations
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Authors
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1 Department of Analytical, Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, 35516, EG
1 Department of Analytical, Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, 35516, EG
Source
Scientia Pharmaceutica, Vol 68, No 2 (2000), Pagination: 173-188Abstract
An accurate simple and selective kinetic procedure for the determination of certain 4-quinolones namely, norfloxacin (I), ofloxacin (II), enrofloxacin (III), fleroxacin (IV), ciprofloxacin (V) and pefloxacin (VI) is described. The procedure is based on reacting the studied compounds in acidic media (0.1 M HCL) with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) in presence of cerium (IV) ammonium sulphate as an oxidant at room temperature for a fixed time of 20 min. For (I), (III), 12 min for (II) and 30 min for IV , V and VI, then the absorbance of the reaction product is measured at 630 nm. The concentration of the studied compounds is computed using the corresponding calibration curve equation for the fixed-time method. The absorbance-concentrations plot is rectilinear over the range 20-100 ug·ml-1 for (I), 2-20 ug·ml-1 for (II), 10-74 ug·ml-1 for (III), 10-60 ug.ml-1 for IV, 10-50 ug·ml-1 for IV and 8-40 ug·ml-1 for VI. The determination of the studied compounds by the fixed-concentration and rate constant methods is feasible with the calibration equation obtained, but the fixed-time method proved to be more applicable. The procedure was applied successfully to commercial tablets and ampoules and the results obtained were compared statistically with the reference methods.Keywords
Kinetic Determination; 4-Quinolone Antibiotics; 3-Methyl-2-Benzothiazolinone Hydrazone HCL (MBTH); Ce. (IV); Pharmaceutical Analysis.References
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- Influence of Soil Properties on P Sorption Characteristics and Yield of Soybean (Glycine Max (L.) Merr.) In Some Alfisols in Benue State, Nigeria
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International Journal of Innovative Research and Development, Vol 3, No 5 (2014), Pagination:Abstract
Studies were conducted using somealfisols in Benue state to evaluate the influence of soil properties on P sorption characteristics and yield of soybean (Glycine max (L.) Merr.).Significant and positive relationships existed between the soil organic matter content and the phosphate adsorption capacity (K) of these soils (r= 0.981). There was also a significant and positive relationship between the aluminum oxides and the clay content of the soils (r= 0.974). There was a negative but significant relationship between the Bray-1 P and the phosphorus buffer capacity (PBC) of these soils (r= -0.975) while the Olsen P related negatively and significantly with the iron oxide content (r= - 0.978) and the calcium P fraction (r= - 0.987) .No significant relationship existed between the solution phosphate concentration(SPC), standard phosphate requirement(SPR) and any of the yield parameters. PBC related negatively and significantly with total P in the plant biomass (r= -0.667) and showed a positive and significant relationship with the seed weight (r= 0.605). K showed a positive and significant relationship with P in plant biomass (r= 0.661). Clay content showed negative and significant relationships with pod number, seed weight and dry matter yield (r= -0.602, - 0.650 and – 0.658) respectively. The relationship between the iron P fraction and the total P in plant biomass was positive and significant (r = 0.587) while that with the seed weight was negative and significant (r= - 0.579). There was no significant relationship between the aluminum P fraction and any of the yield parameters but the calcium P fraction showed significant and positive relationships with the pod number and seed weight. (r = 0.633 and 0.687). Bray -1 P also showed a positive and highly significant relationship with the dry matter yield (r = 0.736). Understanding the phosphorus adsorption chemistry of these soils would be essential in the estimation and management of fertilizer rates and practices aimed at obtaining an optimum yield of soybean on these soils.
Keywords
Alfisols, Soil Properties, P Sorption Characteristics, Yield, Soybean, Relationships, Benue state, NigeriaFull Text