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Co-Authors
- Muhammad Ridwan Mostafa
- Anwar Hossain Choudhury
- Swati Paul
- Md. Omar Faruk
- Srikanta Chowdhury
- Md. Golam Kabir
- S. M. Zahid Hosen
- Talha Bin Emran
- T. A. Chowdhury
- Golam Kabir
- Dwaipayan Sikdar
- Aninda Kumar Nath
- Zia Uddin
- Ankit Tamrakar
- Mayukh Jana
- Supradip Mandal
- Tarashankar Maity
- Vibhor kumar Jain
- Bindu Jain
- Roshni Tandey
- Milan Hait
- Suprodip Mandal
- Utpal Jana
- Raju Dash
- Asraful Alam
- Md. Junaid
- D. Mridha
- S. Kayal
- S. Beura
- Kamlesh Singh
- Alok Thakur
- Ashish Manigauha
- Anish Chandy
Journals
- Research Journal of Humanities and Social Sciences
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- Asian Journal of Research in Pharmaceutical Sciences
- Research Journal of Science and Technology
- Asian Journal of Pharmaceutical Analysis
- Asian Journal of Pharmacy and Technology
- Research Journal of Pharmaceutical Dosage Form and Technology
- Research Journal of Pharmacognosy and Phytochemistry
- Asian Journal of Research in Chemistry
- Asian Journal of Pharmaceutical Research
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Saha, Dibyajyoti
- Achieving Millennium Development Goals by 2015 in Bangladesh: Dream and Reality
Abstract Views :838 |
PDF Views:3
Authors
Affiliations
1 Department of Sociology, University of Chittagong, Chittagong, BD
2 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
1 Department of Sociology, University of Chittagong, Chittagong, BD
2 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
Source
Research Journal of Humanities and Social Sciences, Vol 4, No 1 (2013), Pagination: 1-11Abstract
Bangladesh is the signatory country to implement Millennium Development Goals by 2015. Bangladesh has achieved remarkable success in eradicate poverty, primary education, gender equality and reduces child mortality. In all aspect of MDGs indicators, Bangladesh has revealed positive sign to meet the target. By reviewing literature related to MDGs, this paper is an attempt to see the progress of MDGs in Bangladesh in terms of all MDGs Goals, and its indicators. This paper highlights that, whereas Bangladesh is on track and need attention for achieving MDGs.Keywords
Millennium Development Goals, Bangladesh, Progress, Status
References
- BRAC.2012. Bangladesh-A Next-11 country in the twenty first century, BRAC Annual Report 2011.Dhaka.
- GED (2005). Bangladesh Unlocking the Potential, National Strategy for Accelerated Poverty Reduction, Dhaka: General Economics Division, Bangladesh Planning Commission, Government of Bangladesh.. p-15.
- Bangladesh. Retrieved August 19, 2012 from http://transition.usaid.gov/bd/bangladesh.html
- GED (2012). Millennium Development Goals, Bangladesh Progress Report 2011. Dhaka: General Economics Division, Bangladesh Planning Commission, Government of Bangladesh.p.7
- MDGs and Bangladesh: Retrieved August 20,2012 from http://www.undp.org.bd/mdgs.php
- Millennium Development Goals. Retrieved August 22,2012,from http://en.wikipedia.org/wiki/Millennium_Development_Goals
- GED (2012). op.cit,p.19
- Titumir, Rashed Al Mahmud,. Rahman,K.M. Mustafizur,2011, Poverty and Inequality in Bangladesh, Unnayan Onneshan-The Innovators, Dhaka, Bangladesh, p.9.
- ILO, UNICEF, UNESCO. (2008), Child Labour and Education in Bangladesh: Evidence and Policy Recommendations, Bangladesh, Dhaka, p.5.
- GED (2012). op.cit,p.38
- The Daily Star.2012.Gender Equity Index on Bangladesh, the Daily Star, The Daily Star, Dhaka, Mach 08, 2012.
- Ahmed, Manzoor. (October2012). Violence-Reversing the culture of impunity, Forum, The Daily Star, Dhaka, Bangladesh, Vol.6. Issue10, p.15.
- GED (2010). Outline Perspective Plan of Bangladesh 2010- 2021: Making vision 2021 a reality, Dhaka: General Economics Division, Bangladesh Planning Commission, Government of Bangladesh. P.20.
- McCarthy, J and Maine, D 1992, A framework for analyzing the determinants of maternal mortality, Studies in Family Planning, Vol. 23, No. 1, pp. 23-33.
- Bangladesh and development: The path through the fields, Retrieved 03/11/2012 from http://www.economist.com/news/briefing/21565617- bangladesh-has-dysfunctional-politics-and-stunted-privatesector- yet-it-has-been-surprisingly
- Maternal and Neonatal Health in Bangladesh, Retrieved October 08,2012 from http://www.unicef.org/bangladesh/Maternal_and_Neonatal_Hea lth.pdf
- HIV and AIDS in Bangladesh, Retrieved October 12,2012 from http://www.unicef.org/bangladesh/HIV_AIDS_in_Bangladesh %281%29.pdf
- HIV /AIDS in Bangladesh. Retrieved October 21,2012, from http://en.wikipedia.org/wiki/HIV/AIDS_in_Bangladesh
- Selim,Dr Shajada..(April, 28, 2011). Malaria situation in Bangladesh, The Daily Sun, Dhaka, Bangladesh.
- The Daily Star.(2012).Bangladesh 5th most disaster prone country, The Daily Star, Dhaka, Saturday, October 13, 2012.
- GED (2010).op.cit, p.81.
- GED.(2012).op.cit,p.87
- Asian Tigers Capital Weekly Update, Dhaka,18 January 2009
- World Bank Data, Retrieved October,23,2012 from http://data.worldbank.org/indicator/IT.CEL.SETS.P2
- Next Eleven. Retrieved October 25,2012 from http://en.wikipedia.org/wiki/Next_Eleven
- Bangladesh : Out of the basket, Retrieved November 3,2012 from http://www.economist.com/news/leaders/21565627- lessons-achievements%E2%80%94yes-reallyachievements% E2%80%94-bangladesh-out-basket
- In Vitro Antioxidant Activity of Methanolic Aerial Part Extract of Mimosa pudica
Abstract Views :264 |
PDF Views:2
Authors
Affiliations
1 Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong-4331, BD
2 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
1 Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong-4331, BD
2 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 4 (2012), Pagination: 202-205Abstract
The methanol crude extracts of the plant parts of Mimosa pudica (Mimosaceae) was screened was screened in vitro for antioxidant activity using the 1, 1-diphenyl-2-picrylhydrazyl-hydrate (DPPH) free radical scavenging assay. On the other hand, the methanol crude extract of the aerial part showed moderate antioxidant activity (IC50 20.512 μg/ml) compared to ascorbic acid (IC50 1.143 μg/ml). The overall experimental results suggest the biologically active constituents present in the methanolic extract of Mimosa pudica and justify its use in folkloric remedies.Keywords
Mimosa pudica, Mimosaceae, DPPH, Antioxidant Activity.References
- Das S, Das S, Pal S, Mujib A, Dey S. (1999) Biotechnology of medicinal plants-Recent advances and potential. 1st Ed. Vol II. pp. 126-139. UK992 Publications, Hydarabad.
- Sreejayan N, Rao MNA. (1997) Nitric oxide scavenging by curcuminoids. J. Pharm Pharmacol. 49: 105-107.
- Vani T, Rajani M, Sarker S, Shishoo CJ. (1997) Antioxidant properties of the Ayurvedic formulation Triphala and its constituents. Int J Prarmacognosy. 35: 313-317.
- Tripathi YB, Chaurasia S, Tripathi E, Upadhyay A, Dubey GP. (1996) Bacopa monniera Linn, as an antioxidant: Mechanism of action. Int. J Exp Biol. 34: 523-526.
- Ghani A. (2003) Medicinal Plants of Bangladesh, 2nd Ed. pp. 302-303. The Asiatic Society of Bangladesh, Dhaka.
- Genest S, Kerr C, Shah A, Rahman MM, Saif-E-Naser EMM, Nigam P, Nahar L, Sarker SD.(2008) Comparative bioactivity studies on two Mimosa species. Bol. Latinoam Caribe. Plant Med Aromaticus. 7(1): 38-43.
- Yuan K, Jia A, Lu JL, Zhu JX. (2007) Structural identification of new C glycosyl flavones from Mimosa pudica. Chin J An Chem. 35: 739-742.
- Balakrishnan N, Bhasker VH, Jayakar B, Sangameswaran B. (2006) Antibacterial activity of Mimosa pudia, Aegle marmelos and Sida cordifolia. Pharmacog Mag. 2(7): 198-199.
- Dinda B, Gosh B, Arima S, Sato N, Harigaya Y (2006) Steroids and terpinoids from Mimosa pudica ischolar_mains. J Indian Chem. Soc. 83: 1044-1046.
- Bum EN, Dawack DL, Schmutz M, Rakotonorina A, Rakotonorina VS, Portet C, Jeker A, Olpe HR, Herding P. (2004) Anticonvulsant activity of Mimosa pudica decoction.Fitoterapia. 75: 309-314.
- Kirk LF, Moller MV, Christensen J, Steak D, Ekpe P, Jaroszewski KW. (2003) A 5- deoxuflavonol derivatives in Mimosa pudica. Biochem Systamatics Ecol. 31: 103-105.
- Brand-Williams, W., Cuvelier, M.E. and Berset, C. 1995.Use of a free radical method to evaluate antioxidant activity, Lebensmittel-Wissenschaft und-Technologie/Food Science and Technology, 28:25-30.
- Koleva II, Van Beek TA, Linssen JPH, de Gischolar_main A, Evstatieva LN (2002) Screening of plant extracts for antioxidant activity: a comparative study on three testing methods. Phytochemical Analysis 13: 8-17
- Kanatt R. Chander et al, 2007 Antioxidant potential of mint (Mentha spicata L.) in radiation process lamb meat. Food chem. 100: 451-458.
- Aqil, F., I. Ahmad and Z. Mehmood, 2006. Antioxidant and free radical scavenging properties of twelve traditionally used Indian medicinal plants. Turk. J. Biol., 30: 177-183.
- Malencic, D., O. Gasic, M. Popovic and P. Boza, 2000. Screening for antioxidant properties of Salvia reflexa hornem. Phytother. Res., 14: 546-548.
- Stivala, L., M. Savio, O. Cazzalini, R. Pizzala and L. Rehak et al., 1996. Effect of -carotene on cell cycle progression of human fibroblasts. Carcinogenesis, 17: 2395-2401.
- Lee, J.J., Leedale, G.F. and Bradbury, P. 2000. An Illustrated Guide to the Protozoa, Second Edition. Society of Protozoologists, Lawrence, Kansas, U.S.A.
- Rice-Evans C, Sampson J, Bramley PM and Holloway DE (1997). Why do we expect carotenoids to be antioxidants in vivo? Free Radical Research 26: 381–398.
- Pharmacognostic Studies of Aerial Part of Methanolic Extract of Plumbago indica L
Abstract Views :262 |
PDF Views:4
Authors
Affiliations
1 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
2 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong
1 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
2 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 2, No 3 (2012), Pagination: 88-90Abstract
The aerial part of Plumbago indica L. (family: Plumbaginaceae) was studied to fix the parameters for pharmacognostical standards. The results of organoleptic study offer a scientific basis for the use of Plumbago indica L. which possess characters like green colour, characteristic odour, mucilaginous and slightly bitter taste. The fluorescence analysis under visible UV light and under UV light by treatment with different chemical reagents showed different colour changes. These created an interest to test the possible phytochemical activity of the plant. In the screening process of Plumbago indica L. indicate the presence of Reducing sugars , Alkaloids, Steroids, Flavonoids and Gums. The Pharmacognostic study was performed by using standard procedure. Further, detailed studies are needed to know whether in-vivo administration of the extracts is beneficial for patients.Keywords
Organoleptic, Fluorescence, Pharmacognostic Study.References
- Reddy, K.J. (2004): Medicinal plant research scenario in India, Info concepts India Inc., pp.25-28.
- Dubey, N.K., Kumar, R. and Tripathi, P. (2004): Global promotion of herbal medicine: India's opportunity, Current Science, 86(1), pp.37-41.
- Gaikwadi, S.S., Vadlamudi, V.P., Waghmaee, S.P., Maral, V.J., Ranteke, V.D. and Dhok, A.P. (2003): Phytochemical analysis of aqueous extract of few medicinal plants, PKV. Res. J., 27(1), pp.91-92.
- Van Der Vijver Lm. Distribution of plumbagin in the Plumbaginaceae. Phytochemistry 1974, Vol 11, Pages 3247- 3248.
- Bala Rathinasabapathi, Walid M. Fouad, and Celia A. Sigua . β- Alanine Betaine Synthesis in the Plumbaginaceae. Purification and Characterization of a Trifunctional, S-Adenosyl-l- Methionine-Dependent N-Methyltransferase from Limonium latifolium Leaves. Plant Physiol. 2001, Vol 126(3), Pages 1241- 1249.
- Jackson, B.P. and Snowdown, D.W. (1968): Powdered vegetable drugs, Cheer Chil Ltd., London, pp.25.
- Kokoshi, G.J., Kokoshi, J.R. and Sharma, F.J. (1958): Fluorescence of powdered vegetable drugs under ultra violet radiation, J. Amer. Pharm. Assn., 38(10), pp.715-717.
- Chase, C.R. and Pratt, R.F. (1949): Fluorescence of powdered vegetable drugs with particular reference to the development of systems of identification, J. American Pharm. Assoc., 38, pp.324- 333.
- Pandey, H.C., Dixit, R.S. and Sharma, H.P. (1984): Addition to the Pharmacognosy of Kalimulri (Curculigo orchioides), Bull. Med. Ethnobot. Res., 5(1-2), pp. 55-56.
- Evaluation of Antimotility Effect of Plumbago indica (L.) on Charcoal Induced Gastrointestinal Motility in Mice
Abstract Views :270 |
PDF Views:4
Authors
Affiliations
1 Department of Pharmacy, BGC Trust University Bangladesh Chittagong, BD
1 Department of Pharmacy, BGC Trust University Bangladesh Chittagong, BD
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 2, No 3 (2012), Pagination: 95-97Abstract
Evaluation of antimotility activity was done in intestine of mice treated with methanolic extract of Plumbago indica L. (MEPI).Charcoal was used as a promotility agent. The antimotility activity with the mean defecation period 302.2 and 376.4min at the dose of 250 and 500mg/kg body weight.Keywords
Plumbago indica L., Gastrointestinal Motility, Chacoal.References
- Massee B, McGahey C: A Framework for Action; Child Diarrhea Prevention. Global healthlink, a publication of the Global Health Council, www.globalhealth.org 2001., (111):
- Harrison TR: Diarrhea and Constipation. In Principles of internal medicine. 16th edition. New York: Macgraw Hill; 2005:224-232.
- Hardman JG, Limbird LE: Goodman's and Gilman's: Drugs affecting gastrointestinal function. In The pharmacological basis of therapeutics. 10th edition. New York: Macgraw Hill; 2001:1023-1024.
- Chitme HR, Chandra R, Kaushik S: Studies on anti-diarrhoeal activity of Calotropis gigantea R.Br. in experimental animals. J Pharm Pharmaceut Sci 2004, 7:70-75.
- Van Der Vijver Lm. Distribution of plumbagin in the Plumbaginaceae. Phytochemistry 1974, Vol 11, Pages 3247-3248.
- Bala Rathinasabapathi, Walid M. Fouad, and Celia A. Sigua . β-Alanine Betaine Synthesis in the Plumbaginaceae. Purification and Characterization of a Trifunctional, S-Adenosyl-l-Methionine-Dependent N-Methyltransferase from Limonium latifolium Leaves. Plant Physiol. 2001, Vol 126(3), Pages 1241-1249.
- Herida Regina Nunes Marona and Maria Beatriz Bastos LUCCHESI , (2004) , Protocol ofr Refine Intestinal Motility in mice and rats, 38: 257-260.
- Overview on Water Resources and Pollution
Abstract Views :196 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmacy, BGC Trust University, Bangladesh, Chittagong, BD
2 Department of Pharmacy, BGC Trust University, Bangladesh, Chittagong, BD
1 Department of Pharmacy, BGC Trust University, Bangladesh, Chittagong, BD
2 Department of Pharmacy, BGC Trust University, Bangladesh, Chittagong, BD
Source
Research Journal of Science and Technology, Vol 4, No 3 (2012), Pagination: 108-114Abstract
Water resources are sources of water that are useful or potentially useful. Uses of water include agricultural, industrial, household, recreational and environmental activities. Water pollution is the contamination of water bodies (e.g. lakes, rivers, oceans, aquifers and groundwater). Water pollution occurs when pollutants are discharged directly or indirectly into water bodies without adequate treatment to remove harmful compounds. Water pollution affects plants and organisms living in these bodies of water. In almost all cases the effect is damaging not only to individual species and populations, but also to the natural biological communities.Keywords
Water, Resources, Pollution, Hydrological.- Comparative Analysis on the Major Nutrient Composition of Locally Available Four Different Varieties of Rice (Oryza sativa) in Bangladesh
Abstract Views :178 |
PDF Views:1
Authors
Srikanta Chowdhury
1,
T. A. Chowdhury
2,
Golam Kabir
2,
Dwaipayan Sikdar
2,
Aninda Kumar Nath
3,
Zia Uddin
3,
Dibyajyoti Saha
3
Affiliations
1 Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong-4331, BD
2 Department of Biochemistry and Molecular Biology, University of Chittagong, BD
3 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
1 Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong-4331, BD
2 Department of Biochemistry and Molecular Biology, University of Chittagong, BD
3 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
Source
Research Journal of Science and Technology, Vol 4, No 1 (2012), Pagination: 13-17Abstract
The aim of the present study was to obtain comparative data on chemical compositions and nutritive values of four different varieties of rice. The results indicated that moisture, ash, total soluble solid and crude fiber contents of the different varieties of rice were in the ranges of 9.98-10.90%, 9.45-11.12%, 10.06-11.25% and 9.35-10.35% respectively. The ranges in the values of total protein, water soluble protein, dry matter, polysaccharide, total sugar, reducing and non-reducing sugar compositions of rice were 12.45-14.06%, 3.20-4.71%, 89.10-90.02%, 10.95-12.25%, 4.35-4.96%, 1.15- 1.45%, and 3.10-3.58% respectively. Vitamin B1 and Vitamin B2 contents of rice were found to be ranged from 2.98-3.81 and 0.61-0.86 mg/100 gm of rice respectively. Twelve amino acids were detected in all of the four varieties of rice in the total form by paper chromatography. Rice contained about 14.95-16.16% oil. Triglyceride, diglyceride, monoglyceride, and nonglyceride were found to be varied from 91.76-93.08%, 1.51-2.30%, 1.45- 1.96% and 3.63-5.24% respectively. Rice oils contained mostly unsaturated fatty acid which was varied from 71.06-74.95%. Total lipids were fractionated into lipid classes by silicic acid column chromatography.Keywords
Rice, Chemical Compositions, Nutritive Values, Chromatography, Fatty Acids.- Comparative Analysis on the Major Nutrient Composition of Locally Available Four Different Varieties of Rice (Oryza sativa) in Bangladesh
Abstract Views :148 |
PDF Views:0
Authors
Srikanta Chowdhury
1,
T. A. Chowdhury
2,
Golam Kabir
2,
Dwaipayan Sikdar
2,
Aninda Kumar Nath
3,
Zia Uddin
3,
Dibyajyoti Saha
3
Affiliations
1 Department of Biochemistry and Molecular Biology, University of Chittagong, BD
2 Department of Biochemistry and Molecular Biology, University of Chittagong, BD
3 Department of Pharmacy, BGC Trust University, Bangladesh, Chittagong, BD
1 Department of Biochemistry and Molecular Biology, University of Chittagong, BD
2 Department of Biochemistry and Molecular Biology, University of Chittagong, BD
3 Department of Pharmacy, BGC Trust University, Bangladesh, Chittagong, BD
Source
Research Journal of Science and Technology, Vol 3, No 6 (2011), Pagination: 346-350Abstract
The aim of the present study was to obtain comparative data on chemical compositions and nutritive values of four different varieties of rice. The results indicated that moisture, ash, total soluble solid and crude fiber contents of the different varieties of rice were in the ranges of 9.98-10.90%, 9.45-11.12%, 10.06-11.25% and 9.35-10.35% respectively. The ranges in the values of total protein, water soluble protein, dry matter, polysaccharide, total sugar, reducing and non-reducing sugar compositions of rice were 12.45-14.06%, 3.20-4.71%, 89.10-90.02%, 10.95-12.25%, 4.35-4.96%, 1.15- 1.45%, and 3.10-3.58% respectively. Vitamin B1 and Vitamin B2 contents of rice were found to be ranged from 2.98-3.81 and 0.61-0.86 mg/100 gm of rice respectively. Twelve amino acids were detected in all of the four varieties of rice in the total form by paper chromatography. Rice contained about 14.95-16.16% oil. Triglyceride, diglyceride, monoglyceride, and nonglyceride were found to be varied from 91.76-93.08%, 1.51-2.30%, 1.45- 1.96% and 3.63-5.24% respectively. Rice oils contained mostly unsaturated fatty acid which was varied from 71.06-74.95%. Total lipids were fractionated into lipid classes by silicic acid column chromatography.Keywords
Rice, Chemical Compositions, Nutritive Values, Chromatography, Fatty Acids.- Pharmacognostic Studies of Aerial Part of Methanolic Extract of Alpinia conchigera Griff
Abstract Views :195 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
1 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
Source
Asian Journal of Pharmaceutical Analysis, Vol 2, No 2 (2012), Pagination: 46-48Abstract
The aerial part of Alpinia conchigera Griff (family: Zingiberaceae,) was studied to fix the parameters for pharmacognostical standards. The results of organoleptic study offer a scientific basis for the use of Alpinia conchigera Griff which possess characters like green colour, characteristic odour, mucilaginous and slightly bitter taste. The fluorescence analysis under visible UV light and under UV light by treatment with different chemical reagents showed different colour changes. These created an interest to test the possible phytochemical activity of the plant. In the screening process of Alpinia conchigera Griff indicate the presence of Reducing sugars, Steroids, Alkaloids, Flavonoids, Saponins and Gums. The Pharmacognostic study was performed by using standard procedure. Further, detailed studies are needed to know whether in-vivo administration of the extracts is beneficial for patients.Keywords
Organoleptic, Fluorescence, Pharmacognostic Study.- Comparative Studies on Sedimentation Parameter of Aluminium Hydroxide and Sodium Bicarbonate, Magnesium Trisilicate, Magnesium Carbonate Suspension
Abstract Views :159 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
1 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
Source
Asian Journal of Pharmacy and Technology, Vol 2, No 4 (2012), Pagination: 133-134Abstract
The sedimentation volume (F) is defined as the ratio of final or ultimate volume to the suspension volume. If the volume of sedimentation in a flocculated suspension equal to the original volume of suspension, then F=1 is pharmaceutically acceptable. When F=0 it means the total drug has sedimented and volume of sediment is negligible. So, more the volume of F more will be therapeutic acceptance. In this study two types of suspension were studied where aluminium hydroxide suspension classed as type-I and sodium-bi-carbonate, magnesium trisilicate, magnesium carbonate suspension classed as ty pe-II suspension. It was observed that the sedimentation volume is more in case of type-I suspension rather than type-II suspension.Keywords
Sedimentation Volume, Aluminium Hydroxide, Sodium Bi Carbonate, Magnesium Trisilicate, Magnesium Carbonate.- Pharmacognostic Studies of Aerial Part of Pouzolzia zeylanica (L.)
Abstract Views :179 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
1 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
Source
Asian Journal of Pharmacy and Technology, Vol 2, No 4 (2012), Pagination: 141-142Abstract
The aerial part of Pouzolzia zeylanica (L.) Benn (fam. Urticaeae) was studied to fix the parameters for pharmacognostical standards. The results of organoleptic study offer a scientific basis for the use of Pouzolzia zeylanica which possess characters like greenish grey colour, characteristic odour and mucilaginous and slightly bitter taste. The fluorescence analysis under visible light and under UV light by treatment with different chemical reagents showed different colour changes. The presence of alkaloids, glycosides, tannins and flavonoids was confirmed during preliminary phytochemical screening.Keywords
Organoleptic, Fluorescence, Phytochemical, Supernatant.- Protein Mass Spectrometry:Novel Approaches in Pharmaceutical Biotechnology
Abstract Views :217 |
PDF Views:0
Authors
Affiliations
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur-495004, C.G., IN
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur-495004, C.G., IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 1, No 2 (2011), Pagination: 25-26Abstract
Protein mass spectrometry refers to the application of mass spectrometry to study the proteins and nowadays it is introduced in proteomies science as well as pharmaceutical biotechnology. Mass spectrometry is an important emerging method for ionization of whole proteins are electrospray ionization (ESI) and matrix assisted laser desorption/ionization (MALDI). In keeping with the performance and mass range of available mass spectrometers, two approaches are used for characterizing proteins. In the first, intact proteins are ionized by either of the two techniques described above, and then introduced to a mass analyzer. This approach is referred to as "top-down" strategy of protein analysis. In the second, proteins are enzymatically digested into smaller peptides using a protease such as trypsin. Subsequently these peptides are introduced into the mass spectrometer and identified by peptide mass fingerprinting or tandem mass spectrometry. Hence this latter approach (also called "bottom up" proteomies) uses identification at the peptide level to infere the existence of proteins.Keywords
Mass Spectrometry, Proteins, Peptides, High Performance Liquid Chromatography, Quantization.- Target Discovery and Validation:Advances in Molecular Pharmacology
Abstract Views :216 |
PDF Views:0
Authors
Affiliations
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur-495004, C.G., IN
2 Bharat Technology, Banitabla, Uluberia, Howrah-711316, IN
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur-495004, C.G., IN
2 Bharat Technology, Banitabla, Uluberia, Howrah-711316, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 1, No 2 (2011), Pagination: 27-28Abstract
The molecular pharmacology involving aspects of biological, medical and pharmaceutical sciences. It is concerned with invention, discovery, design, identification and preparation of biologically active compounds, the study of their metabolism, the interpretation of their mode of action at the molecular level. The physiology based drug discovery follows physiological readouts and by contrast, the road of target based drugs discovery begins with identifying the function of a possible therapeutic target and its role in disease. The validation of a molecular target in vitro usually proceeds the validation of a therapeutic concept in vivo; together this defines its clinical potential. The present article gives disease mechanisms of target discovery and outline of target validation with its pathways.Keywords
Target Discovery, Target Validation, Molecular Target, Disease Genes, Molecular Pharmacology.- Design and Potential of Mass Spectrometry
Abstract Views :174 |
PDF Views:0
Authors
Affiliations
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur-495004, C.G., IN
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur-495004, C.G., IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 1, No 1 (2011), Pagination: 1-2Abstract
The mass spectrometry technique deals with a beam of electrons which produce an ionic molecule or ionic fragments of the original species. The resulting assortment of charged particle is then separated than according to their masses. The spectrum produced, known as mass spectrum is record information regarding various masses produced and their relative abundance. This article highlights potential approaches and theoretical aspects of mass spectrometry with its basic design.Keywords
Mass Spectrometry, Ionized Fragments, Mass Analyzer, Gas Chromatography, Ion Mobility Spectrometry.- In Vitro Screening of Antifungal Activity of Methanol Extract of Alpinia Conchigera Griff against Some Pathogenic Species of Fungi
Abstract Views :209 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
Source
Asian Journal of Pharmacy and Technology, Vol 2, No 2 (2012), Pagination: 44-46Abstract
The main objective of the present study was to determine the methanolic extract of Alpinia conchigera Griff for antifungal activity. To determine the antifungal activitiy agar disc diffusion method was used. The antifungal activity of the extracts was compared with standard drug Fluconazole (500 μg/disc). The methanol extract of Alpinia conchigera Griff showed very good antifungal activity ranging from zone of inhibition (7.0-26) mm and Aspergillus niger was the most susceptible fungal strain of the methanolic extract of Alpinia conchigera Griff. Due to these promising results, further in vivo studies over Alpinia conchigera Griff must be conducted.Keywords
Alpinia conchigera Griff, Methanol Extract, Antifungal Activity.- Cytotoxic Activity of Methanolic Extract of Plumbago Indica L. (Family: Plumbaginaceae)
Abstract Views :167 |
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Authors
Affiliations
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
2 Department of Pharmacy, BGC Trust University, Chittagong, IN
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
2 Department of Pharmacy, BGC Trust University, Chittagong, IN
Source
Asian Journal of Pharmacy and Technology, Vol 2, No 2 (2012), Pagination: 59-61Abstract
Investigation with crude methanolic extract of Plumbago indica L. was carried out to evaluate its possible cytotoxic activity. Pharmacological history of this plant promoted us to check the possible cytotoxic activity. By using the brine shrimp lethality bioassay method, the LC50 and LC90 value of Plumbago indica L. was assayed. In this study, DMSO was used as solvent. The extract evidence cytotoxic activity against brine shrimp nauplii and calculated LC50 and LC90 value was 5.0μg/ml and 12 μg/ml respectively.Keywords
Plumbago indica L. , Cytotoxicity, LC50, Brine Shrimp Lethality Bioassay, LC90.- Analgesic Activity of Methanol Extract of Plumbago Indica (L.) by Acetic Acid Induced Writhing Method
Abstract Views :194 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
Source
Asian Journal of Pharmacy and Technology, Vol 2, No 2 (2012), Pagination: 74-76Abstract
The present study was designed to investigate Analgesic activity of methanolic extract of Plumbago indica (L.) using Acetic Acid Induced Writhing method. Methanolic extract was administered intraperitoneally at doses of 250 mg/kg and 500 mg/kg to Young Swiss-albino mice. Methanol Extract of Plumbago indica (L.) showed significant inhibition in pain response induced by thermal and mechanical stimuli in dose dependent manner. The obtained results provide promising baseline information for the potential use of these crude extract in the treatment of pain.Keywords
Plumbago indica (L.), Analgesic, Acetic Acid, Writhing Method.- Pharmacognostic Studies on Aerial Part of Methanolic Extract of Mimosa Pudica
Abstract Views :163 |
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Authors
Affiliations
1 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
2 Department of Biochemistry and Molecular Biology, University of Chittagong, BD
1 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
2 Department of Biochemistry and Molecular Biology, University of Chittagong, BD
Source
Asian Journal of Pharmacy and Technology, Vol 2, No 3 (2012), Pagination: 101-103Abstract
The aerial part of Mimosa pudica (family: (Mimosaceae)) was studied to fix the parameters for pharmacognostical standards. The results of organoleptic study offer a scientific basis for the use of Mimosa pudica which possess characters like deep green colour, characteristic odour and slightly bitter taste. The fluorescence analysis under visible UV light by treatment with different chemical reagents showed different colour changes. These created an interest to test the possible phytochemical activity of the plant. In the screening process of Mimosa pudica indicate the presence of alkaloids, glycoloids, flavonoids, terpenoids, steroids, phlobatanins, tannins and saponins .The pharmacognostic study was performed by using standard procedure. Further, detailed studies are needed to know whether in-vivo administration of the extracts is beneficial for patients.Keywords
Organoleptic, Phytochemical, Fluorescence, Mimosa pudica.- Pharmacognostic Studies of Aerial Part of Methanolic Extract of Tridax procumbens
Abstract Views :164 |
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Authors
Affiliations
1 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
1 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
Source
Asian Journal of Pharmacy and Technology, Vol 2, No 3 (2012), Pagination: 107-109Abstract
The aerial part of Tridax procumbens(family: Asteraceae) was studied to fix the parameters for pharmacognostical standards.The results of organoleptic study offer a scientific basis for the use of Tridax procumbens which possess characters like green colour, characteristic odour, mucilaginous and slightly bitter taste. The fluorescence analysis under visible UV light and under UV light by treatment with different chemical reagents showed different colour changes. These created an interest to test the possible phytochemical activity of the plant. In the screening process of Tridax procumbens indicate the presence of Reducing sugars, Steroids, Alkaloids, Glycosides, Tannins, Flavonoids and Gums. The Pharmacognostic study was performed by using standard procedure. Further, detailed studies are needed to know whether in-vivo administration of the extracts is beneficial for patients.Keywords
Organoleptic, Fluorescence, Pharmacognostic Study.- Cancer Treatment Strategy-An Overview
Abstract Views :166 |
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Authors
Affiliations
1 School of Pharmacy, Chouksey Engineering College. Lal Khadan, Masturi Road, Bilaspur-495004, C.G, IN
2 Calcutta Institute of Pharmaceutical Technology and A.H.S., Howrha-711316, W. B, IN
3 Bharat Technology, Banitabla, Uluberia, Howrah-711316, IN
1 School of Pharmacy, Chouksey Engineering College. Lal Khadan, Masturi Road, Bilaspur-495004, C.G, IN
2 Calcutta Institute of Pharmaceutical Technology and A.H.S., Howrha-711316, W. B, IN
3 Bharat Technology, Banitabla, Uluberia, Howrah-711316, IN
Source
Asian Journal of Pharmacy and Technology, Vol 1, No 2 (2011), Pagination: 28-33Abstract
Cancer is any disorder of cell growth that results in invasion and destruction of surrounding healthy tissues by abnormal cells, which have arisen from normal cells, whose nature is permanently changed. The exact mechanism through which a normal cell is transform to a tumor cell is still not clear and is considered as very complex in nature comprising of several steps though in recent years considerable advancement in knowledge have been obtained in molecular mechanisms, growth regulatory factors, environmental effects, diet and food habits etc. Tumors that remain localized can usually be cured by surgery or radiotherapy even when enormous. Cancer, still regarded as the most progressive and dreadful disease, is posing a great social and economical problem globally since it has been estimated that in the year 2005 about 10.9 million new cases have been registered while about 6.7 million people had died from cancer while the respective figures for Indian people might be about 1 million of new incidences and 6 lakh of deaths. Data from USA showed that an estimated death of about 5.5 lakh had occurred in 20051. The number of new cancer cases is also increasing globally at a fast rate.Keywords
Radiotherapy, Chemotherapy, Alkylating Agents, HDAC Inhibitor, Proteasome Inhibitors, Telomerase Inhibitor, Antiangiogenic Drugs, COX-2 Inhibitors.- Good Laboratory Practice: Design and Utility
Abstract Views :167 |
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Authors
Affiliations
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan Masturi Road, Bilaspur - 495 004, C.G, IN
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan Masturi Road, Bilaspur - 495 004, C.G, IN
Source
Asian Journal of Pharmacy and Technology, Vol 1, No 1 (2011), Pagination: 1-3Abstract
Good laboratory practice is an essential part of good manufacturing practice detailed in Schedule M to the Drugs and Cosmetic rule. It involves a number of good practices in the QC laboratory which are to be undertaken to carry out an analysis with a defined degree of accuracy and precision. The importance of GLP is the implementation of GMP detailed in Schedule M cannot be overemphasized. The role of GLP is the development of quality test data, mutual acceptance of data avoids duplication of data, avoids technical barriers to trade and also protection of human health and the environment. The present article highlights important application of GLP in the design of accuracy, precision, reliability etc.Keywords
Good Laboratory Practice, Quality Control, Quality Assurance.- Cytotoxic Activity of Ethanol Extract of Leea indica Leaf
Abstract Views :208 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 2, No 4 (2012), Pagination: 137-139Abstract
The cytotoxic activity of ethanol extract of Leea indica (Burm. f.) Merr., (Family: Leeaceae) leaf has been investigated in the present study. The cytotoxic activity of the L. indica ethanol extract was assessed by brine shrimp lethality bioassay method. In brine shrimp lethality bioassay LC50 value of L. indica ethanol extract was found 2.4771μg/ml with 95% confidence limit where the lower and upper limits were 2.2561 and 2.6981 μg/ml respectively, which indicates that the leaf extract has promising cytotoxic effect. The present study demonstrates that ethanol extract of L. indica leaf has significant cytotoxic effect.Keywords
Leea indica, Cytotoxic, Brine Shrimp Lethality Bioassay, LC50.- In Vitro Screening of Antifungal Activity of Methanol Extract of Plumbago indica L. against some Pathogenic Species of Fungi
Abstract Views :161 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 2, No 2 (2012), Pagination: 55-57Abstract
The main objective of the present study was to determine the methanolic extract of Plumbago indica L. for antifungal activity. To determine the antifungal activity, agar disc diffusion method was used. The antifungal activity of the extracts was compared with standard drug Fluconazole (500 μg/disc). The methanol extract of Plumbago indica L. showed very good antifungal activity ranging from zone of inhibition (10.0-27.0) mm and Candida albicans was the most susceptible fungal strain of the methanolic extract of. Plumbago indica L .Due to these promising results, further in vivo studies over Plumbago indica L. must be conducted.Keywords
Plumbago indica L., Methanol Extract, Antifungal Activity.- Analgesic Activity of Methanol Extract of Alpinia conchigera Griff by Acetic Acid Induced Writhing Method
Abstract Views :191 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 2, No 2 (2012), Pagination: 62-65Abstract
The present study was designed to investigate Analgesic activity of methanolic extract of Alpinia conchigera Griff, using Acetic Acid Induced Writhing method. Methanolic extract was administered intraperitoneally at doses of 250 mg/kg and 500 mg/kg to Young Swiss-albino mice. Methanol Extract of Alpinia conchigera Griff showed significant inhibition in pain response induced by thermal and mechanical stimuli in dose dependent manner. The obtained results provide promising baseline information for the potential use of these crude extract in the treatment of pain.Keywords
Alpinia conchigera Griff, Analgesic, Acetic Acid, Writhing Method.- An Ontological Design: Two Stage Mouse Skin Carcinogenesis Induced By DMBA and Promoted By Croton Oil
Abstract Views :209 |
PDF Views:0
Authors
Affiliations
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur-495004, (C.G), IN
2 Dept. of Chemistry, Dr. C. V. Raman University, Kargi Road, Kota, Bilaspur, C.G.- 495113, IN
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur-495004, (C.G), IN
2 Dept. of Chemistry, Dr. C. V. Raman University, Kargi Road, Kota, Bilaspur, C.G.- 495113, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 2, No 1 (2012), Pagination: 1-3Abstract
DMBA is a polycyclic aromatic hydrocarbon which may be used as cancer initiator and croton oil is used as cancer promoter in murine skin which composed of phorbol esters. Formation of stable DMBA-DNA adduct can lead to the induction of mutation that activate proto-oncogen or inactivate tumor suppressor genes as an important event during tumor initiation. In mouse skin the promotion process like increased cell proliferation, suppression of apoatosis and induction of the production of ROS and RNS that cause increase membrane lipid peroxidation and decrease cellular antioxidant stores. ROS plays an important role in the process of mutagenesis and carcinogenesis specially tumor promotion. The main aim and rationally of this ontological design is very potent for screening of new cancer chemopreventive agents as well as anticancer drug development.Keywords
Carcinogenesis, Polycyclic Aromatic Hydrocarbon, DMBA, Croton Oil.- Xenobiotics, Oxidative Stress, Free Radicals Vs. Antioxidants: Dance Of Death to Heaven's Life
Abstract Views :245 |
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Authors
Affiliations
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur-495004, C.G, IN
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur-495004, C.G, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 1, No 2 (2011), Pagination: 36-38Abstract
A xenobiotic is a compound that is foreign to the body. Xenobiotics can produce a variety of biological effects, including pharmacologic responses, toxicity, genes, immunologic reactions and cancer. Oxidative stress is a leading cause to damage cells by oxidation. The rate at which oxidative damage is induced (input) and the rate at which it is efficiently repaired and removed (output). A free radical is an atom or molecule that has one or more unpaired electron(s). These are highly reactive species capable of wide spread, indiscriminate oxidation and peroxidation of proteins, lipids and DNA which can lead to significant cellular damage and even tissue and/or organ failure. Antioxidants are molecules that slow or prevent the oxidation other chemicals. Oxidation reactions can involve the production of free radicals which can form dangerous chain reactions. Antioxidants can terminate these chain reactions by removing radical intermediates and can inhibit other oxidation reactions by being oxidized themselves. Antioxidants are often reducing agents such as thiols or phenols. Therefore, we need antioxidants to ensure our defence mechanism for neutralizing harmful radicals.Keywords
Xenobiotics, Oxidative Stress, Free Radicals, Antioxidants, Polyphenolic Compounds.- Radiopharmaceuticals and Radio Opaque Contrast Media: Practice, Prospects and Potentials
Abstract Views :179 |
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Authors
Affiliations
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur- 495004, C.G, IN
2 Dept. of Chemistry, Dr.C.V. Raman University, Kargi Road, Kota, Bilaspur, C.G, IN
3 Dept. of Pharmacy, Bharat Technology, Uluberia-711316, W.B, IN
4 Dept. of Pharmacy, Annamalai University, Annamalai Nagar, IN
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur- 495004, C.G, IN
2 Dept. of Chemistry, Dr.C.V. Raman University, Kargi Road, Kota, Bilaspur, C.G, IN
3 Dept. of Pharmacy, Bharat Technology, Uluberia-711316, W.B, IN
4 Dept. of Pharmacy, Annamalai University, Annamalai Nagar, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 1, No 1 (2011), Pagination: 4-8Abstract
The compounds or substance which emit radiation and which are used in medicine area called radiopharmaceuticals. Radio opaque substances are those compounds (both inorganic and organic) that have the property of casting a shadow on x-ray films. Radiopharmaceuticals preparations are the preparations containing one or more radionuclides. Radionuclides are radioactive and transform spontaneously into other nuclides. The unstable nuclei undergo spontaneous nuclear changes in order to achieve stability by emitting radiation are called radioisotopes or radionuclides. The radioactive substances disintegrates or decays with the emission of certain particles or certain quantities of energy which is always characteristics of the isotope.The present article gives various ideas about radiations, radioactivity, radioisotopes, radio opaque and contrast media, radioactive pollution as well as quality control and also pharmaceutical applications of radioisotopes.Keywords
Radiopharmaceuticals, Radio Opaque, Contrast Media, Radioisotopes.- Drug Bank:An Update-Resource for in Silico Drug Discovery
Abstract Views :183 |
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Authors
S. M. Zahid Hosen
1,
Dibyajyoti Saha
1,
Raju Dash
1,
Talha Bin Emran
1,
Asraful Alam
1,
Md. Junaid
1
Affiliations
1 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
1 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 3 (2012), Pagination: 166-171Abstract
Drug Bank plays a vital role in the research of bioinformatics/chemo informatics. Drug bank is a richly annotated resource that combines detailed drug data with comprehensive drug target and drug action information. Since its first release in the 2006, Drug Bank has been widely used to facilitate, in silico drug target discovery, drug design, drug docking or screening, drug metabolism prediction, drug interaction prediction and general pharmacological education. First drug bank was released in 2006 with version 1.0. Now it is successfully updated by the releasing of 2.0, 2.5 and 3.0 version. First released in 2006, Drug Bank has become widely used by pharmacists, medicinal chemists, pharmaceutical researchers, clinicians, educators and the general public . The database contains 6707 drug entries including 1436 FDA-approved small molecule drugs, 134 FDA-approved biotech (protein/peptide) drugs, 83 nutraceuticals and 5086 experimental drugs. Additionally, 4228 non-redundant protein (i.e. drug target/enzyme/transporter/carrier) sequences are linked to these drug entries. Each DrugCard entry contains more than 150 data fields with half of the information being devoted to drug/chemical data and the other half devoted to drug target or protein data. Since its last update in 2008, DrugBank has been greatly expanded through the addition of new drugs, new targets and the inclusion of more than 40 new data fields per drug entry (a 40% increase in data 'depth'). These data field additions include illustrated drug-action pathways, drug transporter data, drug metabolite data, pharmacogenomic data, adverse drug response data, ADMET data, pharmacokinetic data, computed property data and chemical classification data. Drug Bank 3.0 also offers expanded database links, improved search tools for drug-drug and food-drug interaction, new resources for querying and viewing drug pathways and hundreds of new drug entries with detailed patent, pricing and manufacturer data. These additions have been complemented by enhancements to the quality and quantity of existing data, particularly with regard to drug target, drug description and drug action data. Drug Bank 3.0 represents the result of 2 years of manual annotation work aimed at making the database much more useful for a wide range of 'Omics' (i.e. pharmacogenomic, pharmacoproteomic, pharmacometabolomic and even pharmacoeconomic) applications.
Keywords
Drug Bank, Database, In silico Drug Discovery.- Overview on Liposome as Drugs Carrier
Abstract Views :185 |
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Authors
Affiliations
1 Balaka, Risi Bankim Sarani, Near Padakhep Club, West Hridaypur, P.O: Hridaypur, Kolkata- 700127, W.B, IN
2 Dept. of Pharmacy, Bharat Technology, Banitabla, Uluberia-711316, W.B., IN
3 Dept. of Pharmacy, Kanak Manjari Institute of Pharmaceutical Sciences, Rourkela-769015, Orissa, IN
4 Nababharat Shiksha Parishad, Orissa, Rourkela-769014, Orissa, IN
1 Balaka, Risi Bankim Sarani, Near Padakhep Club, West Hridaypur, P.O: Hridaypur, Kolkata- 700127, W.B, IN
2 Dept. of Pharmacy, Bharat Technology, Banitabla, Uluberia-711316, W.B., IN
3 Dept. of Pharmacy, Kanak Manjari Institute of Pharmaceutical Sciences, Rourkela-769015, Orissa, IN
4 Nababharat Shiksha Parishad, Orissa, Rourkela-769014, Orissa, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 6 (2010), Pagination: 374-377Abstract
The main objective of drug delivery systems is to deliver a drug effectively, specifically to the site of action and to achieve greater efficacy and minimise the toxic effects compared to conventional drugs. Amongst various carrier systems, liposomes have generated a great interest because of their versatility and have played a significant role in formulation of potent drugs to improve therapeutics. Enhanced safety and efficacy have been achieved for a wide range of drug classes, including antitumor agents, antivirals, antimicrobials, vaccines, gene therapeutics etc. Liposomes were first described by British hematologist Dr Alec D Bangham. These are vesicular concentric structures, range in size from a nanometer to several micrometers, containing a phospholipid bilayer and are biocompatible, biodegradable and nonimmunogenic.
There are three types of liposomes - MLV (multilamillar vesicles), SUV (Small Unilamellar Vesicles) and LUV (Large Unilamellar Vesicles). Phospholipids are amphipathic, i.e., part of their structure is hydrophilic and the other is hydrophobic. Liposome can carry both hydrophobic and hydrophilic molecules. They can be filled with drugs and used to deliver drugs. Another interesting property of liposomes is their natural ability to target cancer by their rapid entry into tumor sites. Anti-cancer drugs such as Doxorubicin (Doxil), Camptothecin etc. are currently being marketed in liposome delivery systems. Liposomes that contain low or high pH can be constructed such that dissolved aqueous drugs will be charged in solution. Another strategy for liposome drug delivery is to target endocytosis events and can also be decorated with opsonins and ligands. The use of liposomes for transformation of DNA into a host cell is known as lipofection. In addition to these applications, liposomes can deliver the dyes to textiles, pesticides to plants, enzymes and nutritional supplements to foods, and cosmetics to the skin. The use of liposomes in nano cosmetology also has many benefits, including improved penetration and diffusion of active ingredients, selective transport of ingredients, greater stability of active, reduction of unwanted side effects, and high biocompatibility. Despite of their potential value, the major obstacles are the physical stability and manufacture of the liposomal products and these problems still remain to be overcome. More liposome based drug formulations can be expected in the near future both for delivery of conventional drugs and for new biotechnology therapeutics such as recombinant proteins, antisense oligonucleotides and cloned genes.
Keywords
Multilamillar Vesicles, Unilamellar Vesicles, Phospholipids.- Aloe Vera Gel for Cure of Alkali Burns
Abstract Views :168 |
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Authors
Affiliations
1 Sri Rawatpura Sarkar Institute of Technology and Science, Raipur, IN
2 School of Pharmacy, Chouksey Engg. College, Lalkhadan, Bilaspur, CG,-495223, IN
3 NRI Institute of Pharmacy, Sajjan Singh Nagar, Raisen road, Bhopal-462021, IN
1 Sri Rawatpura Sarkar Institute of Technology and Science, Raipur, IN
2 School of Pharmacy, Chouksey Engg. College, Lalkhadan, Bilaspur, CG,-495223, IN
3 NRI Institute of Pharmacy, Sajjan Singh Nagar, Raisen road, Bhopal-462021, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 4 (2011), Pagination: 158-161Abstract
Alkaline skin burns are treated for a long time using water as a diluting and neutralizing agent. This is because it is found that acid wash leads to acid base neutralizing exothermic reactions which leads to secondary tissue damage. Literatures reveal that Aloe vera exhibits a mild acidic property which will be useful in treatment of alkaline burn. The illustrious biological activities of Aloe vera embrace promotion of wound healing, antifungal activity, anti-inflammatory, anticancer, immunomodulatory properties and enhance the dermal absorption and skin permeation. The aim of this research is to study the use of aloe vera gel in treatment of burns, due to alkaline reagents in laboratories or industrial accidents. Time taken for healing wound occurred due to alkali burn has been improved.Keywords
Aloe Vera, Alkali Burns, Absorption Enhancement, Skin Permeation, Excipient.- Lead Optimization:Research Pathways in Medicinal Chemistry
Abstract Views :208 |
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Authors
Affiliations
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur, C.G.-495004, IN
2 Depatment of Chemistry, Dr. C.V. Raman University, Kargi Road, Kota, Bilaspur, C.G.-495004, IN
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur, C.G.-495004, IN
2 Depatment of Chemistry, Dr. C.V. Raman University, Kargi Road, Kota, Bilaspur, C.G.-495004, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 4 (2011), Pagination: 509-510Abstract
Lead optimization employs a combination of empirical, combinatorial and rational approaches that optimize leads through continuous, multi speed process based on knowledge gained at each stage. The testing of analog series result in quantitative information that correlates changes in chemical structure to biological and pharmacological data generate to established SARs. The medicinal chemistry- lead optimization blends synthetic chemistry, molecular modeling, computational biology, structural genomics and pharmacology to discover and design new drugs and investigate their interaction at the molecular, cellular and whole animal level. The present pathways give mechanism of animal PK/PD/ADMEs highlighting the toxicity, formulation and delivery.
Keywords
Lead Optimization, Medicinal Chemistry.- Pharmacognostic Studies on Methanolic Extract of the Aerial Part of Leucas zeylanica(L.)
Abstract Views :182 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
Source
Asian Journal of Pharmaceutical Research, Vol 2, No 4 (2012), Pagination: 142-143Abstract
The aerial part of Leucas zeylanica (L.) Benn (Fam. Lamiaceae) was studied to fix the parameters for pharmacognostical standards. The results of organoleptic study offer a scientific basis for the use of Leucas zeylanica which possess characters like deep green colour, characteristic odor and mucilaginous and slightly bitter taste. The fluorescence analysis under visible light and under UV light by treatment with different chemical reagents showed different colour changes. The presence of alkaloids, steroids, tannins, flavonoids and glycosides were confirmed during preliminary phytochemical screening.Keywords
Organoleptic, Fluorescence, Phytochemical, Supernatant.- Pharmacognostic Studies of Aerial Part of Methanolic Extract of Vernonia patula
Abstract Views :189 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
Source
Asian Journal of Pharmaceutical Research, Vol 2, No 3 (2012), Pagination: 94-96Abstract
The aerial part of Vernonia patula (family: Asteraceae) was studied to fix the parameters for pharmacognostical standards. The results of organoleptic study offer a scientific basis for the use of Vernonia patula which possess characters like green colour, characteristic odour, mucilaginous and slightly bitter taste. The fluorescence analysis under visible UV light and under UV light by treatment with different chemical reagents showed different colour changes. These created an interest to test the possible phytochemical activity of the plant. In the screening process of Vernonia patula indicate the presence of Reducing sugars, Steroids, Alkaloids, Glycosides, Tannins, and Gums. The Pharmacognostic study was performed by using standard procedure. Further, detailed studies are needed to know whether in-vivo administration of the extracts is beneficial for patients.Keywords
Organoleptic, Fluorescence, Pharmacognostic Study.- Comparative Study of the Efficacy of Barleria prionitis Leaf Extracts against Bacteria
Abstract Views :158 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
Source
Asian Journal of Pharmaceutical Research, Vol 2, No 3 (2012), Pagination: 107-110Abstract
Bacterial infections are one of the prominent causes of health problems, physical disabilities and mortalities around the world. Symptoms and complications associated with bacterial infections such as fever, chills, headache, nausea, vomiting and organ failures affect patient's life severely. Medicinal plants are a rich source of antimicrobial agents and provide a safer and cost effective way of treating bacterial infections. We report in this work for the first time, the potent antibacterial activity of different leaf extracts of Barleria prionotis L. The objectives of this study were to examine the antibacterial effect using different extract [petroleum ether (40°-60°), chloroform, ethanol (70%)] and column fraction of Barleria prionitis Linn (Acanthaceae) leaf and to determine the minimum inhibitory concentration (MIC) of the different Barleria prionitis Linn (Acanthaceae) leaf extract and column fraction. S. typhi (Ty 2-59) [Chloroform extract, Column fraction]; V. cholerae (DN-6) [Column fraction]; V. cholerae (793) [Chloroform extract]; V. cholerae (813) [Chloroform extract, Column fraction]; M. luteus (ATCC-9341) [Chloroform extract, Column fraction]; L. sporogenus [Chloroform extract] and Citrobacter [Chloroform extract, Column fraction] were inhibited at 5mg/ml level. B. subtils (PI-6633) [Pet. ether extract] inhibited at 3.33mg/ml level. B. cereus (PI-11778) [Column fraction] and Providencia [Chloroform extract, Column fraction] were inhibited at 50mg/ml level.Keywords
Barleria prionitis, Antibacterial Activity, Minimum Inhibitory Concentration (MIC).- Evaluation of Antimotility Effect of Alpinia conchigera Griff on Charcoal Induced Gastrointestinal Motility in Mice
Abstract Views :156 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
Source
Asian Journal of Pharmaceutical Research, Vol 2, No 2 (2012), Pagination: 71-74Abstract
Evaluation of antimotility activity was done in intestine of mice treated with methanolic extract of Alpinia conchigera Griff (MEAC). Charcoal was used as a promotility agent. The antimotility activity with the mean defecation period 297.4 and 371.2 min at the dose of 250 and 500mg/kg body weight.Keywords
Alpinia conchigera Griff, Gastrointestinal Motility, Chacoal.- Cytotoxic Activity of Methanolic Extract of Alpinia conchigera Griff (Family:Zingiberaceae)
Abstract Views :163 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
Source
Asian Journal of Pharmaceutical Research, Vol 2, No 2 (2012), Pagination: 86-88Abstract
Investigation with crude methanolic extract of Alpinia conchigera Griff was carried out to evaluate its possible cytotoxic activity. Pharmacological history of this plant promoted us to check the possible cytotoxic activity. By using the brine shrimp lethality bioassay method, the LC50 and LC90 value of Alpinia conchigera Griff were assayed. In this study, DMSO was used as solvent. The extract evidence cytotoxic activity against brine shrimp nauplii and calculated LC50 and LC90 value was 6.1μg/ml and 12.2 μg/ml respectively.Keywords
Alpinia conchigera Griff, Cytotoxicity, LC50, Brine Shrimp Lethality Bioassay, LC90.- Skin Cancer:Dance of Death
Abstract Views :187 |
PDF Views:1
Authors
Affiliations
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur-495004, C.G., IN
2 Bharat Technology, Banitabla, Uluberia, Howrah-711316, IN
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur-495004, C.G., IN
2 Bharat Technology, Banitabla, Uluberia, Howrah-711316, IN