Informatics Publishing Limited

V. I. Zalavadiya ¹, V. K. Shah ², D. D. Santani ³, M. S. Patel ¹, J. M. Fosi ¹, A. K. Chaudhary ¹

Affiliations
1 Shree Krishna Institute of Pharmacy, Bechraji, Gujarat, IN
2 Claris Life Sciences Ltd., Ahmadabad, Gujarat, IN
3 Rofel College of Pharmacy, Vapi, Gujarat, IN

Abstract

Achyranthes aspera is a common plant found throughout India. Before the introduction of modern medicines, disease treatment was entirely managed by herbal remedies. It is estimated that about 80% of the world population residing in the vast rural areas of the developing and under developed countries still depends mainly on medicinal plants. It is quite obvious that the plant is widely used in traditional medicinal system of India and has been reported to possess hepatoprotective, anti-inflammatory, antitussive, antifungal and also used to check wounds healing and antibacterial properties. Achyranthes aspera is a very important plant for its large number of medicinal properties as well as medicinally important chemicals like ecdysterone, achyranthine, betaine, pentatriaontane, 6-pentatriacontanone, hexatriacontane and tritriacontane. The plant shows many pharmacological activities like, anti-allergic, cardiovascular, nephroprotective, antiparasitic, hypoglyceamic, analgesic and antipyretic. The present article gives an account of updated information on its phytochemical and pharmacological properties. The review reveals that wide numbers of phytochemical constituents have been isolated from the plant which possesses activities like antiperiodic, diuretic, purgative, laxative, antiasthmatic, hepatoprotective, anti-allergic and various other important medicinal properties. For the last few decades or so, extensive research work has been done to prove its biological activities and pharmacology of its extracts.

Keywords

Achyranthes aspera, phytochemical, pharmacological, biological

Full Text

     

Vipul Shah ¹, Vrunda Shah ², D. D. Santani ³

Affiliations
1 Claris Life Sciences Ltd., Ahmadabad, Gujarat, IN
2 Shree Krishna Institute of Pharmacy, Bechraji, Gujarat, IN
3 Rofel College of Pharmacy, Vapi, Gujarat, IN

Abstract

Asthma is best described as a chronic disease that involves inflammation of the pulmonary airways and bronchial hyperresponsiveness that results in the clinical expression of a lower airway obstruction that usually is reversible. Physiologically, bronchial hyperresponsiveness is documented by decreased bronchial airflow after bronchoprovocation with methacholine or histamine. Other triggers that provoke airway obstruction include cold air, exercise, viral upper respiratory infection, cigarette smoke, and respiratory allergens. Bronchial asthma is a common problem with enormous medical and economics impacts. It is an inflammatory disease of the airways associated with intermittent episodes of bronchospasm. Asthma is not uncommon in the elderly patients. Prevalence of asthma is similar in older and younger adults. Due to rapid industrialization and urbanization, asthma prevalence is predicted to increase more rapidly in the coming years. Despite the availability of a wide range of drugs for the treatment of asthma, the relief offered by them is mainly symptomatic and short lived. Moreover the side effects of these drugs are also quite disturbing. Medicinal Plants have been the highly esteemed source of medicine throughout human history. They are widely used today indicating that they are a growing part of modern, hightech medicine. About 25-30 percent of today's prescription drugs contain chemical moieties derived from plants. The Indian system of medicine i.e Ayurveda alongwith classic texts like Bheshajya Ratnavali has a longstanding tradition that offers a unique insight into comprehensive approach to asthma management through proper care of the respiratory tract. Ayurvedic formulations used in the management of asthma, therefore, judiciously combine herbs to support the physiology of respiration, these herbs apart from exerting bronchial action also possess concomitant properties like antioxidant to support the digestive, cardiac, nerve functions and expectorant as well as just plain soothing herbs. In the present article an attempt has been made to review antiasthmatic medicinal plants with their active chemical constituent and possible mechanism of action.

Keywords

Asthma, Symptomatic, Respiration, Bronchospasm, Airways.

Full Text

     

R. H. Gokani ¹, M. A. Rachchh ², S. K. Lahiri ³, D. D. Santani ⁴, M. B. Shah ³

Affiliations
1 “Shrikunj” 3-Archana Park, B/H Krishna Complex, University Road, Rajkot-360005, Gujarat, IN
2 Dept. of Pharmacognosy, S.J. Thakkar Pharmacy College, Rajkot, IN
3 Dept. of Pharmacognosy, L. M. College of Pharmacy, Ahmedabad, IN
4 Dept. of Pharmacology L. M. College of Pharmacy, Ahmedabad, IN

Abstract

Root of Premna integrifolia known under common name Arni/Agnimantha which is an important constituent of well known formulation, Dashmularistha used for various ailments. In the present study methanolic extract of the ischolar_mains was evaluated for its in-vitro antioxidant activity using the anti radical, superoxide scavenging, anti lipid peroxidation, hydroxyl radical scavenging and nitric oxide scavenging, assays. The extract showed significant anti-oxidant activity in all the assays. The study scientifically demonstrated the use of P. integrifolia as a potential source of natural antioxidant.

Keywords

P. integrifolia, Verbanaceae, Anti-Oxidant Activity.

Full Text