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Co-Authors
- Mahendra Prakash
- G. Venkata Prasad
- S. Sravani
- B. Mohammed Ishaq
- M. Madhu
- Sreenivasulu Munna
- J. Srinivasa Rao
- J. Naga Mallika
- M. Sri Madhu Sri
- G. Raveendra Babu
- M. Prasada Rao
- G. Prashanthi
- Y. Pradeep Kumar
- D. Swarna Latha
- N. Pramod
- S. Chand Basha
- K. Anusha
- K. Madhuri
- M. Rajvikram
- S. Ramkumar
- S. Leoponraj
Journals
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Gopinath, C.
- "Tanka" for Human and Live-stock Consumption
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Authors
Source
Indian Forester, Vol 88, No 11 (1962), Pagination: 861-864Abstract
No abstract- Development and Validation of UV-Spectrophotometric Method for Determination of Cephalexin
Abstract Views :564 |
PDF Views:2
Authors
G. Venkata Prasad
1,
S. Sravani
1,
B. Mohammed Ishaq
1,
M. Madhu
1,
Sreenivasulu Munna
1,
C. Gopinath
1
Affiliations
1 Department of Pharmaceutical Analysis, Annamacharya college of Pharmacy, Rajampet, Kadapa Dist, A.P, IN
1 Department of Pharmaceutical Analysis, Annamacharya college of Pharmacy, Rajampet, Kadapa Dist, A.P, IN
Source
Asian Journal of Research in Chemistry, Vol 6, No 5 (2013), Pagination: 490-494Abstract
To develop simple, sensitive, selective and accurate UV Spectrophotometric methods for the determination of Cephalexin in bulk drug and pharmaceutical formulations (Capsules). The absorbances were measured at 261(Method A) and 257 nm (Method B). The methods was found to be linear from a quantitation ranges of 5μg/ml to 40μg/ml (Method A) in Phosphate Buffer pH 2.0 and 5μg/ml to 50μg/ml (Method B) in 0.1 N HCl. The regression of the curves was Y = 0.020x - 0.021 (Method A) and Y = 0.014x - 0.102 (Method B). The methods gave satisfactory results in terms of repeatability and intermediate precision (RSD<1.010%) (Method A) and (RSD<0.589%) (Method B) 0.855 μg/mL and 2.85 μg/mL (Method A) and 2.357 μg/mL and 7.857 μg/mL were the LOD and LOQ values, respectively. The methods was validated and proved to be robust and rugged. The results of analysis for these methods have been validated statistically and by recovery studies.Keywords
Cephalexin, Spectroscopic Method, Phosphate Buffer (Ph 2.0), 0.1 N HclReferences
- The United States Pharmacopoeia XXIII. 1993. United States Pharmacopoeia Convection. Rockville, Maryland, U. S. A.
- Agbaba D. et al., HPTLC assay of cephalexin and cefaclor in pharmaceuticals. Biomedical Chromatography, 1998, 12, 133- 135.
- Halkar U.P. and Bhandari N.P. Simultaneous determination of cephalexin and probenecid in pharmaceutical preparations by HPTLC. Indian Drugs, 1998, 35, 382–383.
- Coran S.A. et. al., Development of a densitometry method for the determination of cephalexin as an alternative to the standard HPLC procedure. Journal of Pharmaceutical and Biomedical Analysis., 1998, 18, 271–274.
- Bhooshan R. and Prashad V., Separation and Identification of Some Cephalosporin’s on Impregnated TLC Plates., Biomedical Chromatography, 1996, 10, 258–260.
- Najib N. M. et. al., High performance liquid chromatographic analysis of cephalexin in serum and urine., Journal of Clinial pharmacy and therapeutics, 2008, 12, 419-426.
- Zendelovska D. et. Al., Simultaneous quantification of cefaclor and cephalexine in bloodplasma using high-performance liquid chromatography with UV detection., Acta Pharm,2002, 52, 243– 250.
- Lee Y.J. and Lee H.S., Simultaneous determination of cefoxitin, cefuroxime, cephalexin and cephaloridine in plasma using HPLC and a column-switching technique. Chromatographia, 1990, 30, 80–84.
- Prayanka P. and Suresh P., Development of colorimetric method for cephalexin in dosage forms, Asian Journal of Pharmaceutics, 2008, 2, 120–122.
- Patel S.A. et. al., Spectrophotometric methods for the estimation of Cephalexin in tablet dosage forms., Indian Journal of Pharmaceutical Sciences, 2006, 68, 278-280.
- Validation of Analytical Procedures: Text And Methodology Q1A (R2), ICH Harmonized Tripartite Guideline, Feb 2003.
- Green J M, A practical guide to analytical method validation, Analytical Chemistry: 1996, 305A.
- Comparative In Vitro Dissolution Assessment of Three Different Brands of Lansoprazole Capsules
Abstract Views :165 |
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Authors
J. Srinivasa Rao
1,
J. Naga Mallika
1,
M. Sri Madhu Sri
2,
G. Raveendra Babu
2,
M. Prasada Rao
2,
C. Gopinath
1
Affiliations
1 Hindu College of Pharmacy, Amravati Road, Guntur, Andhrapradesh, IN
2 MAM College of Pharmacy, Narasaraopet, Guntur (Dt), Andhrapradesh, IN
1 Hindu College of Pharmacy, Amravati Road, Guntur, Andhrapradesh, IN
2 MAM College of Pharmacy, Narasaraopet, Guntur (Dt), Andhrapradesh, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 3, No 2 (2011), Pagination: 57-65Abstract
The present study has made an attempt to compare % release of three different brands (Lanzol, Lanzap and Lan) of lansoprazole using USP Type II (Paddle) dissolution Apparatus in three Media (phosphate buffer pH 6.0, 6.8 and 7.4). It has been observed from the dissolution profile that more than 90% of Lansoprazole is released from each capsule at 30.0 minutes time point. The F1 and F2 values of Lanzol Vs Lanzap are 7.02% and 59.87%, Lanzol Vs Lan are 1.51% and 81.99% and Lan Vs Lanzop are 0.38% and 59.98% at pH6.0; The F1 and F2 values of Lanzol Vs Lanzap are 7.65% and 55.95%, Lanzol Vs Lan are 3.91% and 69.18%, Lan Vs Lanzop are 3.90% and 61.99% at pH 6.8.The F1 and F2 values of Lanzol Vs Lanzap are 4.12% and 67.10%, Lanzol Vs Lan 2.46%, 72.60%, Lan Vs Lanzop 1.70% and 84.53% at pH 7.4. In all three Media % Release pattern is similar; However in pH 7.4 media % Release is about 100% at 45minutes.Keywords
Lansoprazole, Dissolution, UV Method.- Synthesis, Characterization, Docking and Biological Evaluation of Tetra Hydro Imidazo [1, 2-A] Pyrazine Derivatives
Abstract Views :186 |
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Authors
Affiliations
1 Dept. of Pharmaceutical Chemistry, QIS College of Pharmacy, Vengamukka Palem, Ongole, 523272, IN
2 Dept. of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, Rajampet, 516126, IN
3 Dept. of Pharmacognosy, Annamacharya College of Pharmacy, Rajampet, 516126, IN
1 Dept. of Pharmaceutical Chemistry, QIS College of Pharmacy, Vengamukka Palem, Ongole, 523272, IN
2 Dept. of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, Rajampet, 516126, IN
3 Dept. of Pharmacognosy, Annamacharya College of Pharmacy, Rajampet, 516126, IN
Source
Asian Journal of Research in Chemistry, Vol 9, No 6 (2016), Pagination: 271-276Abstract
Novel Tetra hydro imidazo[1,2-a] pyrazine derivatives have been synthesized by Treatment of pyrazine-2- carboxylic acid with thionyl chloride in methanol yielded methyl pyrazine-2-carboxylate.This up on treatment with alcoholic ammonia gave pyrazinamide, further it was undergone Hoffman's degradation, gave 2-amino pyrazine after that it was refluxed for 26 hrs with chloro acetaldehyde , sodium bicarbonate gave imidazo[1,2-a] pyrazine and hydrogen gas was passed on it in the presence of palladium on carbon yielded tetra hydro imidazo[1,2-a] pyrazine ,which was treated with different substituent's to get the novel derivatives. Synthesized compounds were identified and characterized by Melting point, TLC, FT-IR, 1H and 13C NMR , MASS and percent purity done by HPLC . Based on characterization and percent purity novel derivatives were subjected for molecular docking , QSAR studies and pharmacological evaluation. Selected compounds were docked on Antioxidant activity using "Thioredoxin peroxidase B" as a target site. QSAR parameters like partition coefficient was studied and showed polar surface area below 140 A0 and passed ADME parameters. Analysis of docking and QSAR studies suggested that remarkable inhibitory activity was exhibited by the derivatives. Hydrogen bond interactions were mapped to confirm their potencies. They were evaluated for In-Vitro Anti-oxidant activity by DPPH method and In-Vitro Anti-diabetic activity by alpha-amylase inhibition assay by DNSA method. Results suggested that electron withdrawing groups like nitro, bromo having compounds shown potent activity. Rest of compounds showed mild to moderate activity.Keywords
Tetra Hydro Imidazo[1,2-A] Pyrazine, Docking and Q SAR, Anti-Oxidant, Anti-Diabetic Activities.- Synthesis, Characterization of 3-chloro 4-(4- Substituted Phenyl -1- (4- Nitro Phenylazetidin -2-one by Microwave Method and Evaluation of their Antibacterial Activity
Abstract Views :199 |
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Authors
Affiliations
1 Dept. of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Rajampet, Kadapa (Dist) A.P, 516115, IN
2 Dept. of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Rajampet, Kadapa (Dist) A.P, 516115, IN
1 Dept. of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Rajampet, Kadapa (Dist) A.P, 516115, IN
2 Dept. of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Rajampet, Kadapa (Dist) A.P, 516115, IN
Source
Asian Journal of Research in Chemistry, Vol 9, No 3 (2016), Pagination: 101-106Abstract
Non classical, High-speed, environmentally benign synthesis with microwaves has attracted researchers for organic synthesis was a considerable amount of attention in recent years. An expeditious one pot microwave irradiation method for preparation of 2- azetidinones is developed. This method has been assessed as greener methodology. In our present study, A series of six novel 2-azetidinones were synthesized, compounds were identified by melting point and thin layer chromatography , functional groups of synthesized compounds were confirmed by IR spectroscopy, compounds were evaluated for their antimicrobial activities. The activities were due to cyclic carbonyl group in 2-azetidinones. Some of the compounds have shown comparative antimicrobial activities against all the microbial strains.Keywords
Microwave Synthesis, 2-Azetedinone, Anti Bacterial Activity.- A Novel Methodology of IoT Implementation in Energy Management
Abstract Views :264 |
PDF Views:0
Authors
Affiliations
1 EEE Department, Sri Venkateswara College of Engineering, Chennai - 602105, Tamil Nadu, IN
1 EEE Department, Sri Venkateswara College of Engineering, Chennai - 602105, Tamil Nadu, IN