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B. Adzu , S. Amos , M. Adamu , K. Gamaniel

Abstract

Objective: To investigate the antinociceptive and anti-inflammatory effect of Annona senegalensis in mice and rats. Materials and Methods: The analgesic effects of the methanolic extract were studied using acetic acid-induced writhing test, hot plate test and formalin test, while the anti-inflammatory effect was evaluated using the egg-albumin induced hind paw oedema in rats. Results: The methanolic extract exhibited antinociceptive activity against the acetic acid writhing test, hot plate test and the late phase of formaline induced nociception and significant anti-inflammatory activity. Conclusion: The analgesic and anti-inflammatory effect of the methanolic extract might be through peripheral mechanisms and thus justifying its folkloric use in the treatement of rheumatic pain.

Keywords

Annona senegalensis, Analgesia, Anti-inflammatory, Rheumatism

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B. Adzu , K. Gamaniel

Abstract

Objective: To investigate the effects of Cassia singueana on the central nervous system in mice. Materials and methods: The effects of methanol extract of Cassia singueana on motor coordination, spontaneous motor activity, pentobarbital sleeping time and exploratory behaviour were evaluated in mice. Results: The extract failed to exhibit activity on motor coordination test, but significantly reduced spontaneous motor activity and exploratory behaviour, and prolonged barbital hypnosis. Conclusion: The extract contains potent neuropharmacological principle with sedative effect.

Keywords

Cassia singueana, Sedation

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