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R. Issarani , B. P. Nagori

Abstract

Objective: The aim of the present investigation was to study the effect of different galactomannans on cholesterol absorption in rabbits. Materials and methods: Guar, fenugreek and locust bean galactomannans of # 200 having different galactose: mannose ratios of 1:2, 1:1 and 1:4 respectively and 1%w/v aqueous dispersion of these galactomannans having viscosities of 3215 ± 280 cps, 1050 ± 80 cps and 600 ± 52 cps respectively were selected for the present study. Antihyperlipidemic activity of galactomannans was studied using cholesterol loaded rabbit model. Cholesterol was administered by gastric gavage in a daily dose of 500mg/kg bodyweight, for induction of hyperlipidemia. The different galactomannans were administered in a daily dose of 250 mg/kg body weight. The study was carried out for a period of 18 days. Blood specimens were collected before commencement of study, on day 9 and on the last day. The total lipid profile in serum was determined using auto-analyzer. Results: All the three galactomannans under study showed significant antihyperlipidemic activity (p<0.05) in comparison to the control group. Guar and fenugreek galactomannans had statistically (p<0.05) a similar effect. Locust bean galactomannan had significantly (p<0.05) a lower activity in comparison to the other two galactomannans. The effects of galactomannans so observed can be explained and correlated with their galactose: mannose ratios i.e. galactomannans with a high galactose: mannose ratio like fenugreek and guar have a better effect in comparison to a galactomannan with low galactose: mannose ratio like locust bean. Conclusion: It is concluded that different galactomannans having different galactose: mannose ratios affect the absorption of cholesterol to different extent.

Keywords

Galactomannans, Galactose: Mannose Ratio, Antihyperlipidemic Activity

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R. Solanki ¹, B. P. Nagori ¹

Affiliations
1 Lachoo Memorial College of Science and Technology, Jodhpur, Rajasthan, IN

Abstract

Skin is the major organ of the human body which plays a vital role in maintaining health of human being. Certain diseases defined as infectious or communicable or transmissible diseases are caused by pathogenic microorganisms. Some of the most common causative microorganisms related with infections include Staphylococcus aureus, Streptococcus pyogenes, Enterococci, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. Most of the diseases spread by the bacteria which invade inside the body through skin. Bacterial infections on skin are the common ailment for generation of other diseases in the body. Bacterial diseases are type of infectious diseases caused by pathogenic bacteria. Symptoms and complications related with bacterial infections such as chills, headache, wound, vomiting and organ failure generally affects the patient's life. Wound on skin can occur in all ages of persons and can causes harm in number of ways. Wound and skin infections represent the invasion of tissues by one or more species of microorganisms. These infections disturbs the body immune system and causes inflammation, tissue damage and thus resulting in delayed wound healing process. This article throws light on three aspects first on various types of microorganisms found responsible for causing wound infection on the skin, second on laboratory tests to diagnose the responsible microorganisms for wound infections and on choice of treatment for wound healing.

Keywords

Skin, Symptoms, Bacteria, Types of Wound Infection, Diagnostic Test, Antibiotics

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Ashok P. Suthar ¹, Sanjay R. Patel ¹, Anand M Shah ¹, Roshan Issarani ², B. P. Nagori ², Rumit M. Shah ³

Affiliations
1 K.N.V. Pharmacy College, Village: Metoda, Rajkot – 360021, IN
2 Dept. of Quality Assurance, Lachoo Memorial College of Science and Technology, Shastrinagar-342003, Jodhpur, IN
3 Vidyabharati Trust College of Pharmacy, Umarakh, Surat, IN

Abstract

New simple, economic, sensitive, accurate UV Spectrophotometric method has been developed for determination of Risperidone in tablet dosage form. Method of estimation for Risperidone based on two wavelengths viz. 238 nm and 276 nm, by solvent mixture of 0.1N HCl: Methanol in the proportion of 30:70. Risperidone shows linearity and obeys Beer’s law in the concentration range of 3 to 27μg ml-1 at both wavelengths. The results of analysis are validated by statistical evaluation and recovery studies, and method can be extended to the analysis of Risperidone in tablet formulations. A kinetic investigation of the peroxide hydrolysis of Risperidone was carried out in 1% and 3% Hydrogen peroxide solution. The rate constant for degradation were estimated as per pseudo-first order kinetic.

Keywords

Risperidone, UV Spectrophotometric Method, λmax, Degradation Kinetic.

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Ramesh Patel ¹, Manoj K. Rathore ¹, B. P. Nagori ¹, G. K. Singh ¹, Prashant K. Desai ¹

Affiliations
1 Lachoo Memorial College of Sci. and Tech., Pharmacy Wing, Jodhpur, Rajasthan- 342005, IN

Abstract

Natural plant remedies have created an enormous need for information about the properties and uses of the medicinal plants. Tribal people and ethnic races throughout the world have developed their own culture, customs, medicinal practices, etc. A large number of wild and cultivated plants are being used by them for the treatment of various ailments, thus a considerable amount of information on medicinal plants is available with these communities. The state of Madhya Pradesh, Gujarat and Rajasthan comprises of a large population of tribal communities belonging to various ethnic groups. These forest dwellers live in forests and possess a vast knowledge on various aspects of plants. Ethno botanical studies on different aspects of many tribal communities have been carried out in various districts of the states. In Madhya Pradesh main tribes of the state are Gond, Bhil, Oraon, Sahariya, Bhilala, Sor, etc. Bhil and Sahariya are the major tribal communities of the district. They move around the forest for their day-to-day requirements, cultural activities and performing rituals. They possess a vast knowledge of the treatment of their cattle through herbs. The method of treatment is traditional and drugs are used in crude form only. Besides medicinal uses, they possess a vast knowledge on other ethno botanical uses of plants. The tribal people, who live in different remote areas of the region under study, treat their various ailments with plant remedies on the basis of their rich heritage knowledge.

Keywords

Ethnobotanical, Traditional Knowledge, Tribal Community, Medicinal Plants.

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Manoj K. Rathore ¹, Mahesh C. Sharma ², M. Goyal ², G. K. Singh ², B. P. Nagori ²

Affiliations
1 C/O Dr. K. L. Mathur, B-12, Shastri Nagar, Jodhpur, Rajasthan, Pin:342003, IN
2 Lachoo Memorial College of Science and Technology, Pharmacy Wing, Jodhpur, Rajasthan, IN

Abstract

Fagonia is a genus of plant in the family Zygophyllaceae is represented in Egypt by 18 species but it was represented by 15 species in Boulos, 2000 and by about 167 species around Mediterranean, Asia and in the North America. Fagonia schweinfurthii (family Zygophyllaceae) is a plant of desert region. It is commonly known as dhamasa and dhamasia. It is small, spiny, erect, undershrubs, more and less grandullar; branches slander, terete, triage, glabrous. Leaves opposite, 1-3 foliate; petioles very variable in length, from 3 - 30 mm long, deeply striate, very slender; stipules 2 pairs of sharp slender thorns, sometimes exceeding 12 mm in length; leaflets linear, acute, sessile or with very short petiolules. Traditionally, the plant has been used to cure a number of ailments by the people living in desert region such as skin eruptions, in heal sores, skin diseases, anti-pyretic, in pain relief, ear infection, venereal diseases, etc. many other diseases. The present paper deals with comprehensive pharmacognostical studies on stem part of this plant, including macroscopical analysis, preliminary examination of stem powder, florescence analysis. This will help in the identification of powder drug prior using in any herbal formulations.

Keywords

Fagonia schweinfurthii, Skin Disease, Venereal Disease, Macroscopical Analysis.

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B. P. Nagori ¹, Shukla Shiv Shankar ¹

Affiliations
1 Lachoo Memorial College of Sciences and Technology (Pharmacy Wing), Jodhpur-342003, Rajasthan, IN

Abstract

A simple, economic and reproducible spectroscopic method has been developed for the determination of cefaclor API and in its pharmaceutical formulations. The spectroscopic method is based on the formation of complex with p-di methyl amino benzaldehyde reagent having absorbance maxima at 484.4 nm. Optimization of reaction was carried out with the factors: buffer strength, reaction time, stability of complex, molar ratio of drug: reagent. The Beer-Lambert’s law was followed in the range of 2.5-15 μg/ml.

Keywords

Cefaclor, Spectrophotometry, P-Di Methyl Amino Benzaldehyde Reagent.

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A. Shrivastava ¹, B. P. Nagori ², P. Saini ³, R. Issarani ², S. S. Gaur ³

Affiliations
1 Deptt. of Pharmaceutical Analysis, B.R. Nahata College of Pharmacy, Mandsaur (M.P), IN
2 Lachoo Memorial College of Science and Technology, Shastri Nagar, Sector-A, Jodhpur (Rajasthan), IN
3 Oasis Test House, Naroll, Ahmedabad (Gujarat), IN

Abstract

A new simple, sensitive, precise and economical spectrophotometric method of analysis for artemether both as a bulk drug and in capsule formulations was developed and validated. The method employed methanol as solvent and 1 N methanolic HCl was used to derivatize drug. This derivatized product was then estimated at 254 nm. The linear regression analysis data for the calibration plots showed good linear relationship with r²=0.9997 in the concentration range 4-36 μg/ml. The mean value of correlation coefficient, slope and intercept were 0.9998±0.000116, 0.0307±0.000133 and 0.0337±0.001945 respectively. The method was validated for precision, accuracy and recovery studies. LOD and LOQ for artemether were found to be 0.2297 (μg/ml) and 0.696 (μg/ml) respectively. The method has been successfully applied in the analysis of marketed formulations.

Keywords

Spectrophotometric Analysis, Artemether.

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